siRNAs: a new wave of RNA-based therapeutics.

This non-specific response to dsRNAleads to global changes in cellular gene expression andapoptosis, masking any specific silencing effect by RNAi inmammalian cells. Recently, however, it was shown that potentand specific gene silencing could be achieved in human cellstransfected with small interfering RNAs (siRNA) of 21 –23 nt,a key intermediate in the RNAi pathway.

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