Brain ageing and dementia: what makes the difference?

The boundaries between non-pathological brain ageing and the dementias are unclear and contentious. Neuropathological examination can detect occasional individuals in whom the microscopic features typical of late-onset Alzheimer's disease are present yet a clinical history of dementia is absent. On

[1]  I. Deary,et al.  Childhood mental ability and dementia , 2000, Neurology.

[2]  D. Selkoe,et al.  Translating cell biology into therapeutic advances in Alzheimer's disease , 1999, Nature.

[3]  C Osmond,et al.  Fetal and infant growth and impaired glucose tolerance at age 64. , 1991, BMJ.

[4]  M. J. Dauncey,et al.  Nutrition–hormone receptor–gene interactions: implications for development and disease , 2001, The Proceedings of the Nutrition Society.

[5]  G. Mcclearn,et al.  Genetic epidemiologic studies on age-specified traits , 2000 .

[6]  L. Guarente,et al.  Genetic pathways that regulate ageing in model organisms , 2000, Nature.

[7]  I. Deary,et al.  Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies , 1997, Diabetes Care.

[8]  I. Craig,et al.  Genetics, environment and cognitive abilities: review and work in progress towards a genome scan for quantitative trait locus associations using DNA pooling. , 2001, The British journal of psychiatry. Supplement.

[9]  Ian J Deary,et al.  Homocysteine, B vitamin status, and cognitive function in the elderly. , 2002, The American journal of clinical nutrition.

[10]  R. Mayeux,et al.  Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. , 2001, American journal of epidemiology.

[11]  J. Miller,et al.  Homocysteine, Alzheimer's disease, and cognitive function. , 2000, Nutrition.

[12]  Ian J. Deary,et al.  Looking down on human intelligence , 2000 .

[13]  T. Morgan,et al.  Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease , 1998, The Journal of Neuroscience.

[14]  G. Boulianne.  Neuronal regulation of lifespan: clues from flies and worms , 2001, Mechanisms of Ageing and Development.

[15]  C. Finch,et al.  Genetics of aging. , 1997, Science.

[16]  Lawrence J. Whalley,et al.  The Ageing Brain , 2001 .

[17]  Sudha Seshadri,et al.  Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease , 2002 .

[18]  G Ratcliff,et al.  Patterns of cognitive decline in presymptomatic Alzheimer disease: a prospective community study. , 2001, Archives of general psychiatry.

[19]  T. Arendt.  Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization , 2001, Neuroscience.

[20]  Ian G. McKeith,et al.  Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales , 2001, The Lancet.

[21]  N. Holbrook,et al.  Oxidants, oxidative stress and the biology of ageing , 2000, Nature.

[22]  Sarah Tomlin,et al.  Microtechnology: Laying it on thick , 1999, Nature.