Clinical radiation nephropathy.

An analysis of the normal tissue effects of irradiation of the kidney is presented. Various clinical syndromes resulting from treatment are described as well as the potential cellular basis for these findings. Effects of concurrent and/or sequential treatment with irradiation and various chemotherapeutic agents are discussed and the impact of these agents on toxicity presented. Adverse consequences of renal treatment in the child is described and possible radiation effects on so-called compensatory hypertrophy following nephrectomy presented. Renal consequences described to date of bone marrow transplantation programs utilizing irradiation are also presented. The necessity of a dose-volume histogram analysis approach to analyzing renal toxic effects in patients followed for long (> 10 year) periods is essential in developing accurate guidelines of renal tolerance.

[1]  P. J. Hoopes,et al.  The pathogenesis of radiation nephropathy in the dog. , 1985, Radiation research.

[2]  J. Maier.  EFFECTS OF RADIATIONS ON KIDNEY, BLADDER, AND PROSTATE. , 1972 .

[3]  J. Stein,et al.  Intra-arterial epinephrine protection against radiation nephritis. A progress report. , 1969, Radiology.

[4]  G. D'angio,et al.  Potentiation of x-ray effects by actinomycin D. , 1959, Radiology.

[5]  R. Luxton.  Radiation nephritis. A long-term study of 54 patients. , 1961, Lancet.

[6]  F. Stewart,et al.  Analysis of the rate of expression of radiation-induced renal damage and the effects of hyperfractionation. , 1986, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[7]  C. Lawton,et al.  Late renal dysfunction in adult survivors of bone marrow transplantation , 1991, Cancer.

[8]  M. Williams,et al.  Radiation-induced renal damage: the effects of hyperfractionation. , 1984, Radiation research.

[9]  M. Tefft.  Radiation related toxicities in National Wilms' Tumor Study Number 1. , 1977, International journal of radiation oncology, biology, physics.

[10]  Powley Jm.  SYMPTOMLESS CANCER IN WOMEN. , 1964 .

[11]  L. Ekelund,et al.  Radiation-induced stenosis of the renal artery causing hypertension: case report. , 1977, The Journal of urology.

[12]  C. Willett,et al.  Renal complications secondary to radiation treatment of upper abdominal malignancies. , 1986, International journal of radiation oncology, biology, physics.

[13]  S. Sallan,et al.  Late onset of renal dysfunction in survivors of bone marrow transplantation. , 1987, International journal of radiation oncology, biology, physics.

[14]  J. Concannon,et al.  Enhancement of x-ray effects on the small intestinal epithelium of dogs by actinomycin D. , 1969, The American journal of roentgenology, radium therapy, and nuclear medicine.

[15]  C. Freeman,et al.  Unilateral radiation nephropathy--the long-term significance. , 1984, International journal of radiation oncology, biology, physics.

[16]  P. J. Hoopes,et al.  Radiation nephropathy in the dog. , 1986, The British journal of cancer. Supplement.

[17]  T. Smith,et al.  Postradiation renovascular hypertension. , 1979, Journal of pediatric surgery.

[18]  Moulder Je,et al.  Effect of sequencing on combined toxicity of renal irradiation and cisplatin. , 1988 .

[19]  P. Evrin,et al.  Serum 2 -microglobulin in renal disease. , 1973, Nephron.

[20]  B. Fish,et al.  Influence of nephrotoxic drugs on the late renal toxicity associated with bone marrow transplant conditioning regimens. , 1991, International journal of radiation oncology, biology, physics.

[21]  R. F. Farr,et al.  The limit of renal tolerance to x-rays; an investigation into renal damage occurring following the treatment of tumours of the testis by abdominal baths. , 1952, The British journal of radiology.

[22]  W. Berdon,et al.  [Renal atrophy without hypertension following abdominal irradiation in infants and children]. , 1969, Annales de radiologie.

[23]  L. F. Fajardo,et al.  Radiation injury in the mouse kidney--I. Sequential light microscopic study. , 1977, International journal of radiation oncology, biology, physics.

[24]  R. Rabinowitz,et al.  Hyperreninemic hypertension secondary to radiation nephritis in a child. , 1985, Urology.

[25]  A. Crummy,et al.  RENAL HYPERTENSION SECONDARY TO UNILATERAL RADIATION DAMAGE RELIEVED BY NEPHRECTOMY. , 1965, Radiology.

[26]  Williams Mv.  The cellular basis of renal injury by radiation. , 1986 .

[27]  R. Peschel,et al.  The treatment of massive hepatomegaly in stage IV-S neuroblastoma. , 1981, International journal of radiation oncology, biology, physics.

[28]  L. Dewit,et al.  Radiation injury in the human kidney: a prospective analysis using specific scintigraphic and biochemical endpoints. , 1990, International journal of radiation oncology, biology, physics.

[29]  J. Concannon,et al.  Effects on renal function: x-radiation combined with systemic actinomycin D. , 1970, The American journal of roentgenology, radium therapy, and nuclear medicine.

[30]  S. Donaldson,et al.  Combination radiation-adriamycin therapy: renoprival growth, functional and structural effects in the immature mouse. , 1980, International journal of radiation oncology, biology, physics.

[31]  S. Donaldson,et al.  John Caffey Award: chemotherapy-induced inhibition of compensatory renal growth in the immature mouse. , 1980, AJR. American journal of roentgenology.

[32]  S. Sallan,et al.  Intravascular hemolysis and renal insufficiency after bone marrow transplantation , 1988 .

[33]  A. S. Warthin.  THE CHANGES PRODUCED IN THE KIDNEYS BY RÖNTGEN IRRADIATION , 1907 .

[34]  F. Stewart,et al.  Progressive development of radiation damage in mouse kidneys and the consequences for reirradiation tolerance. , 1988, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[35]  R. Krochak,et al.  Radiation nephritis. Clinical manifestations and pathophysiologic mechanisms. , 1986, Urology.

[36]  S. Keidan.  Actinomycin d in the treatment of cancer in children , 1966 .

[37]  J. Wilson,et al.  Tumor and normal tissue tolerance for fractionated low-dose-rate radiotherapy. , 1990, International journal of radiation oncology, biology, physics.

[38]  D. White,et al.  The histopathologic basis for functional decrements in late radiation injury in diverse organs , 1976, Cancer.

[39]  T. Phillips,et al.  Ultrastructural and Cellular Effects of Ionizing Radiation1 , 1972 .

[40]  J. Hopewell,et al.  Functional recovery in the irradiated kidney following removal of the contralateral unirradiated kidney. , 1986, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[41]  I. Mackay,et al.  Late radiation nephritis after gastric x-irradiation for peptic ulcer. , 1971, The Quarterly journal of medicine.

[42]  L. J. Cole,et al.  X-ray-induced glomerulosclerosis in rats: modification of lesion by food restriction, uninephrectomy, and age. , 1966, Journal of gerontology.

[43]  L. Avioli,et al.  Early effects of radiation on renal function in man. , 1963, The American journal of medicine.

[44]  N. Jaffe,et al.  Bilateral Wilm's tumor. , 1978, International journal of radiation oncology, biology, physics.

[45]  N. Jaffe,et al.  Effect of low dose irradiation on renal enlargement in children following nephrectomy for Wilms' tumor. , 1981, Acta radiologica. Oncology.

[46]  I. Turesson.  The progression rate of late radiation effects in normal tissue and its impact on dose-response relationships. , 1989, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.