2,3,7,8-Tetrachlorodibenzo-p-dioxin toxic effects and tissue levels in animals from the contaminated area of seveso, Italy

After the environmental contamination by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the area of Seveso, Italy, thousands of small domestic animals (mainly rabbits and poultry) died within a few weeks. Autopsies on dead animals showed various pathological signs, such as hepatic lesions and haemorrhage. TCDD was monitored in animal tissues by gas chromatography-mass fragmentography; rabbit liver levels corresponded fairly well to soil contamination, which indicated that this species can be used as a tool for tracking the presence of TCDD in the environment.

[1]  A. Hay.  Toxic cloud over Seveso , 1976, Nature.

[2]  B. N. Gupta,et al.  General biological effects of TCDD in laboratory animals. , 1973, Environmental health perspectives.

[3]  H. Merker,et al.  A survey of the embryotoxic effects of TCDD in mammalian species. , 1973, Environmental health perspectives.

[4]  J. Casida,et al.  Metabolic stability of 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin in mammalian liver microsomal systems and in living mice , 1973, Archives of environmental contamination and toxicology.

[5]  M. Meselson,et al.  An Improved Analysis for Tetrachlorodibenzo-p-dioxins , 1973 .

[6]  V. K. Rowe,et al.  Toxicology of chlorinated dibenzo-p-dioxins. , 1973, Environmental health perspectives.

[7]  D. Firestone,et al.  Studies of the chick edema disease. 10. Toxicity of chick edema factors in the chick, chick embryo, and monkey. , 1973, Poultry science.

[8]  A M Hay,et al.  TETRACHLORODIBENZO-p-DIOXIN RELEASE AT SÉVESO. , 1977, Disasters. The Journal of Disaster Studies, Policy and Management.

[9]  R. Kimbrough.  The toxicity of polychlorinated polycyclic compounds and related chemicals. , 1974, CRC critical reviews in toxicology.

[10]  G. Fries,et al.  Retention and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin by rats. , 1975, Journal of agricultural and food chemistry.

[11]  R. Fanelli,et al.  Identification and Quantitative Determination of 2,3,7,8-Tetrachlorodibenzo-para-Dioxin in Animals From a Contaminated Area , 1978 .

[12]  Studies of the chick edema disease. 9. Response of chicks fed or singly administered synthetic edema-producing compounds. , 1972, Poultry science.

[13]  J. Q. Rose,et al.  Excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. , 1973, Environmental health perspectives.