Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA.

[1]  G. Warnock,et al.  Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice , 2012, Diabetes.

[2]  Anthony Beucher,et al.  Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development. , 2012, Developmental biology.

[3]  E. Stanley,et al.  The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells , 2012, Diabetologia.

[4]  Allon M. Klein,et al.  Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. , 2011, Developmental biology.

[5]  C. Wright,et al.  Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. , 2011, Genes & development.

[6]  F. C. Pan,et al.  Pancreas organogenesis: From bud to plexus to gland , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[7]  A. Grapin-Botton,et al.  Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[8]  C. Wright,et al.  Context-specific a-tob-cell reprogramming by forced Pdx 1 expression , 2011 .

[9]  S. Bonner-Weir,et al.  Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells , 2011, Diabetologia.

[10]  Luc Bouwens,et al.  Recent Advances and Prospects in the Differentiation of Pancreatic Cells From Human Embryonic Stem Cells , 2010, Diabetes.

[11]  I. Artner,et al.  MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner , 2010, Diabetes.

[12]  Pei-Rong Wang,et al.  Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. , 2010, Cell stem cell.

[13]  Robin Goland,et al.  Generation of pluripotent stem cells from patients with type 1 diabetes , 2009, Proceedings of the National Academy of Sciences.

[14]  S. Bonner-Weir,et al.  Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. , 2009, Developmental biology.

[15]  S. Bonner-Weir,et al.  p38 MAPK is a major regulator of MafA protein stability under oxidative stress. , 2009, Molecular endocrinology.

[16]  G. Gittes,et al.  Developmental biology of the pancreas: a comprehensive review. , 2009, Developmental biology.

[17]  Douglas A. Melton,et al.  In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.

[18]  E. Kroon,et al.  Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo , 2008, Nature Biotechnology.

[19]  S. Bonner-Weir,et al.  Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. , 2008, Developmental biology.

[20]  M. Sander,et al.  The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells , 2007, Development.

[21]  I. Artner,et al.  MafB is required for islet β cell maturation , 2007, Proceedings of the National Academy of Sciences.

[22]  Umut Dursun,et al.  Supplemental Data Temporal Control of Neurogenin 3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types , 2007 .

[23]  E. Kroon,et al.  Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells , 2006, Nature Biotechnology.

[24]  S. Bonner-Weir,et al.  A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. , 2006, Developmental biology.

[25]  I. Artner,et al.  MafB: An Activator of the Glucagon Gene Expressed in Developing Islet α- and β-Cells , 2006 .

[26]  I. Artner,et al.  MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. , 2006, Diabetes.

[27]  R. Hammer,et al.  The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. , 2005, Developmental biology.

[28]  J. D. Engel,et al.  MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion , 2005, Molecular and Cellular Biology.

[29]  H. Kaneto,et al.  A Crucial Role of MafA as a Novel Therapeutic Target for Diabetes*♦ , 2005, Journal of Biological Chemistry.

[30]  J. Whitsett,et al.  Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction , 2005, Nucleic acids research.

[31]  Susan E. Schonhoff,et al.  Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. , 2004, Developmental biology.

[32]  M. Magnuson,et al.  Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.

[33]  A. Freiesleben,et al.  Maturation of human milk. , 1963 .