论文信息 - Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells. - 字舞流文

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

P. Hipskind | D. Clawson | D. Manglicmot | Michael D. Kaufman | Sheng-Bin Peng | Xiaoyi Zhang | L. Kays | D. Flynn | J. J. Starling | D. Mccann | J. Henry | Youyan Zhang | Jennie L. Walgren | A. Wrobleski | S. Wise | Weiping Lu | T. Caldwell | Thomas J. Rutkoski | Molly M. Hood | K. Lobb | Y. M. Ahn | Bryan D. Smith | Sherry Guo | H. Telikepalli | Lawrence E Chun | J. Cohen | Phenil J. Patel | C. Logan | L. Vogeti | Subha Vogeti | J. Clay | C. Groshong | David Miller | Lakshminarayana Vogeti | Aaron D. Wrobleski | Lawrence Chun