Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent

[1]  Muriel T. Davisson,et al.  Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice , 1997, Nature Genetics.

[2]  J. Manson,et al.  Characterisation of two promoters for prion protein (PrP) gene expression in neuronal cells. , 1997, Gene.

[3]  J. Hainfellner,et al.  Pathology and Immunocytochemistry of a Kuru Brain , 1997, Brain pathology.

[4]  J. Hope,et al.  Protease-resistant PrP deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy. , 1996, The Journal of general virology.

[5]  S. Prusiner,et al.  Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. , 1996, Genes & development.

[6]  A. Aguzzi,et al.  Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie. , 1996, The EMBO journal.

[7]  H. Sato,et al.  Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent , 1995, Journal of virology.

[8]  Richard C. Moore,et al.  Double Replacement Gene Targeting for the Production of a Series of Mouse Strains with Different Prion Protein Gene Alterations , 1995, Bio/Technology.

[9]  I. Mcconnell,et al.  PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology. , 1994, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[10]  S. Prusiner,et al.  Structure and polymorphism of the mouse prion protein gene. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[11]  S. Prusiner,et al.  Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[12]  H. Fraser,et al.  Transmission of bovine spongiform encephalopathy and scrapie to mice. , 1992, The Journal of general virology.

[13]  S. Prusiner,et al.  Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Bell,et al.  Neuropathology of spongiform encephalopathies in humans. , 1993, British medical bulletin.

[15]  A. Aguzzi,et al.  Mice devoid of PrP are resistant to scrapie , 1993, Cell.

[16]  S. Prusiner,et al.  Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse. , 1993, Genetics.

[17]  I. Mcconnell,et al.  Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice. , 1992, The Journal of general virology.

[18]  H. Fraser,et al.  Transmission of bovine spongiform encephalopathy and scrapie to mice , 2007 .

[19]  J. Mcwhir,et al.  A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency. , 1992, Nucleic acids research.

[20]  S. Prusiner,et al.  Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. , 1992, Genes & development.

[21]  S. Prusiner,et al.  Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice , 1991, Neuron.

[22]  H. Fraser,et al.  The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis. , 1991, The Journal of general virology.

[23]  Stephen J. DeArmond,et al.  Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication , 1990, Cell.

[24]  B. Chesebro,et al.  Analysis of linkage between scrapie incubation period and the prion protein gene in mice. , 1990, The Journal of general virology.

[25]  P. McBride,et al.  Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie , 1989, Neuroscience Letters.

[26]  R. Somerville,et al.  Post-mortem immunodiagnosis of scrapie and bovine spongiform encephalopathy. , 1989, Journal of virological methods.

[27]  A. Clarke,et al.  Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells , 1989, Cell.

[28]  M. Lovett,et al.  Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time , 1988, Molecular and cellular biology.

[29]  S. Prusiner,et al.  Distinct prion proteins in short and long scrapie incubation period mice , 1987, Cell.

[30]  M. Jeffrey,et al.  A novel progressive spongiform encephalopathy in cattle , 1987, Veterinary Record.

[31]  I. Mcconnell,et al.  Linkage of the scrapie-associated fibril protein (PrP) gene and Sinc using congenic mice and restriction fragment length polymorphism analysis. , 1987, The Journal of general virology.

[32]  P. Cortelli,et al.  Fatal familial insomnia and dysautonomia with selective degeneration of thalamic nuclei. , 1986, The New England journal of medicine.

[33]  G. Multhaup,et al.  The major polypeptide of scrapie‐associated fibrils (SAF) has the same size, charge distribution and N‐terminal protein sequence as predicted for the normal brain protein (PrP). , 1986, The EMBO journal.

[34]  S. Prusiner,et al.  Linkage of prion protein and scrapie incubation time genes , 1986, Cell.

[35]  S. Prusiner,et al.  Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene , 1986, Cell.

[36]  S. Prusiner,et al.  Separation and properties of cellular and scrapie prion proteins. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[37]  A. Dickinson,et al.  Genetic control of amyloid plaque production and incubation period in scrapie-infected mice. , 1985, Journal of neuropathology and experimental neurology.

[38]  M. Braunfeld,et al.  Identification of prion amyloid filaments in scrapie-infected brain , 1985, Cell.

[39]  S. Prusiner,et al.  Genetic control of scrapie and Creutzfeldt-Jakob disease in mice. , 1983, Journal of Immunology.

[40]  P. Hochstein,et al.  POTENTIAL VARIANTS OF PHENYLKETONURIA , 1975, The Lancet.

[41]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[42]  L. Sternberger,et al.  THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES , 1970, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[43]  H. Fraser,et al.  The sequential development of the brain lesion of scrapie in three strains of mice. , 1968, Journal of comparative pathology.

[44]  H. Fraser,et al.  Identification of a gene which controls the incubation period of some strains of scrapie agent in mice. , 1968, Journal of comparative pathology.

[45]  H. Fraser,et al.  Distribution of Experimentally Induced Scrapie Lesions in the Brain , 1967, Nature.

[46]  A. Dickinson,et al.  Genetical control of the incubation period in mice of the neurological disease, scrapie , 1964, Heredity.

[47]  R. L. Chandler Encephalopathy in mice produced by inoculation with scrapie brain material. , 1961, Lancet.

[48]  D. Gajdusek,et al.  Degenerative disease of the central nervous system in New Guinea; the endemic occurrence of kuru in the native population. , 1957, The New England journal of medicine.

[49]  A. Jakob,et al.  Über eigenartige erkrankungen des zentralnervensystems mit bemerkenswertem anatomischen befunde , 1921 .

[50]  H. Creutzfeldt Über eine eigenartige herdförmige erkrankung des zentralnervensystems (Vorläufige mitteilung) , 1920 .

[51]  Thomas A. Kunkel,et al.  Rapid and efficient site-specific mutagenesis without phenotypic selection. , 1985, Proceedings of the National Academy of Sciences of the United States of America.