Hsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex

[1]  Yan Guan,et al.  Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics , 2021, Cancer cell international.

[2]  Hong Zhang,et al.  Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis. , 2021, Biochemical pharmacology.

[3]  Hong Zhang,et al.  Small-molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance , 2021, Leukemia.

[4]  Hong Zhang,et al.  A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction. , 2021, European journal of medicinal chemistry.

[5]  Yingang Feng,et al.  The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients , 2020, The Journal of Biological Chemistry.

[6]  M. La Noce,et al.  The role of autophagy in resistance to targeted therapies. , 2020, Cancer treatment reviews.

[7]  P. Agostinis,et al.  Mitophagy in Cancer: A Tale of Adaptation , 2019, Cells.

[8]  Yingyu Chen,et al.  AMPK and Autophagy. , 2019, Advances in experimental medicine and biology.

[9]  A. Birbrair,et al.  Mitophagy-driven metabolic switch reprograms stem cell fate , 2018, Cellular and Molecular Life Sciences.

[10]  Heng Wu,et al.  Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy , 2018, Cellular & Molecular Biology Letters.

[11]  C. K. Das,et al.  Pro-survival autophagy and cancer cell resistance to therapy , 2018, Cancer and Metastasis Reviews.

[12]  B. Tang,et al.  Hsp70 participates in PINK1-mediated mitophagy by regulating the stability of PINK1 , 2018, Neuroscience Letters.

[13]  D. McConkey The integrated stress response and proteotoxicity in cancer therapy. , 2017, Biochemical and biophysical research communications.

[14]  L. Ye,et al.  p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation , 2016, Cellular & Molecular Biology Letters.

[15]  P. Matarrese,et al.  Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation , 2016, Autophagy.

[16]  Mason R. Mackey,et al.  Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress , 2015, Proceedings of the National Academy of Sciences.

[17]  N. Chandel,et al.  Jnk2 promotes stress-induced mitophagy and suppresses inflammasome activation by targeting smARF for degradation , 2015, Nature Immunology.

[18]  Y. Kitagishi,et al.  Functions and characteristics of PINK1 and Parkin in cancer. , 2015, Frontiers in bioscience.

[19]  J. Wells,et al.  Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. , 2014, Chemistry & biology.

[20]  S. Cullen,et al.  Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy. , 2014, Molecular cell.

[21]  D. Vaux,et al.  Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak , 2014, Proceedings of the National Academy of Sciences.

[22]  Scott E. Martin,et al.  High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy , 2013, Nature.

[23]  T. Pandita,et al.  Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy , 2013, Proceedings of the National Academy of Sciences.

[24]  G. Kroemer,et al.  Molecular mechanisms of selective autophagy , 2012, Cell Death and Differentiation.

[25]  C. Rudin,et al.  Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer , 2013, Molecular Cancer.

[26]  Ye Xu,et al.  The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells. , 2012, Cancer letters.

[27]  D. Rubinsztein,et al.  Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules , 2012, Molecular cell.

[28]  A. Thorburn,et al.  Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy , 2012, Autophagy.

[29]  Zhichao Zhang,et al.  A novel BH3 mimetic S1 potently induces Bax/Bak‐dependent apoptosis by targeting both Bcl‐2 and Mcl‐1 , 2011, International journal of cancer.

[30]  Zhichao Zhang,et al.  3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies. , 2011, Journal of medicinal chemistry.

[31]  D. Klionsky,et al.  Regulation mechanisms and signaling pathways of autophagy. , 2009, Annual review of genetics.

[32]  Osamu Takeuchi,et al.  Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. , 2009, Molecular cell.

[33]  G. Kroemer,et al.  Bcl-2 family members: Dual regulators of apoptosis and autophagy , 2008, Autophagy.

[34]  J. Vicencio,et al.  BH3-Only Proteins and BH3 Mimetics Induce Autophagy by Competitively Disrupting the Interaction between Beclin 1 and Bcl-2/Bcl-XL , 2007, Autophagy.

[35]  D. Hardie,et al.  Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes , 2006, The Journal of experimental medicine.

[36]  N. Mizushima The pleiotropic role of autophagy: from protein metabolism to bactericide , 2005, Cell Death and Differentiation.