Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method uses the nuclear electric properties of the spin I = 9/2 isotope 83Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase-induced model of emphysema. A significant 83Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase-treated lungs compared with the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface-to-volume ratio in the emphysema model that was validated by histology. The finding supports usage of 83Kr SQUARE as a new biomarker for surface-to-volume ratio changes in emphysema.

[1]  G. Snider,et al.  Animal models of emphysema. , 1986, The American review of respiratory disease.

[2]  Hiroto Hatabu,et al.  Pulmonary hyperpolarized noble gas MRI: recent advances and perspectives in clinical application. , 2014, European journal of radiology.

[3]  I. Hall,et al.  Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr☆ , 2014, Magnetic resonance imaging.

[4]  D. Shaw,et al.  Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications☆ , 2013, Journal of magnetic resonance.

[5]  D. Shaw,et al.  Validating Excised Rodent Lungs for Functional Hyperpolarized Xenon-129 MRI , 2013, PloS one.

[6]  H. Coxson,et al.  Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. , 2013, Journal of applied physiology.

[7]  John P. Mugler,et al.  Hyperpolarized 129Xe MRI of the human lung , 2013, Journal of magnetic resonance imaging : JMRI.

[8]  K. Stupic,et al.  Pathway to Cryogen Free Production of Hyperpolarized Krypton-83 and Xenon-129 , 2012, PloS one.

[9]  J. Remy,et al.  Krypton ventilation imaging using dual-energy CT in chronic obstructive pulmonary disease patients: initial experience. , 2012, Radiology.

[10]  Jan Wolber,et al.  Direct visualisation of collateral ventilation in COPD with hyperpolarised gas MRI , 2011, Thorax.

[11]  J. Repine,et al.  Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation , 2011, Physics in medicine and biology.

[12]  Christopher S. Stevenson,et al.  Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance. , 2011, Pharmacology & therapeutics.

[13]  Isabel Dregely,et al.  Hyperpolarized Xenon‐129 gas‐exchange imaging of lung microstructure: First case studies in subjects with obstructive lung disease , 2011, Journal of magnetic resonance imaging : JMRI.

[14]  Jan Wolber,et al.  Diffusion‐weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease , 2011, Magnetic resonance in medicine.

[15]  K. Stupic,et al.  Hyperpolarized 131Xe NMR spectroscopy , 2011, Journal of magnetic resonance.

[16]  Grace Parraga,et al.  Imaging of lung function using hyperpolarized helium‐3 magnetic resonance imaging: Review of current and emerging translational methods and applications , 2010, Journal of magnetic resonance imaging : JMRI.

[17]  R. Rizi,et al.  Quantitative assessment of lung ventilation and microstructure in an animal model of idiopathic pulmonary fibrosis using hyperpolarized gas MRI. , 2010, Academic radiology.

[18]  Edwin K Silverman,et al.  Chronic obstructive pulmonary disease phenotypes: the future of COPD. , 2010, American journal of respiratory and critical care medicine.

[19]  Dmitriy A Yablonskiy,et al.  Quantification of lung microstructure with hyperpolarized 3He diffusion MRI. , 2009, Journal of applied physiology.

[20]  A. Bankier,et al.  CT of pulmonary emphysema - current status, challenges, and future directions , 2009, European Radiology.

[21]  B. Hochhegger,et al.  CT of pulmonary emphysema: current status, challenges, and future directions , 2009, European Radiology.

[22]  Z. Cleveland,et al.  Density-independent contributions to longitudinal relaxation in 83Kr. , 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

[23]  Hiroto Hatabu,et al.  Human pulmonary imaging and spectroscopy with hyperpolarized 129Xe at 0.2T. , 2008, Academic radiology.

[24]  S. Patz,et al.  Large production system for hyperpolarized 129Xe for human lung imaging studies. , 2008, Academic radiology.

[25]  W. MacNee,et al.  Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) , 2008, European Respiratory Journal.

[26]  Richard A. Guyer,et al.  Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI study. , 2008, Journal of applied physiology.

[27]  Hans-Ulrich Kauczor,et al.  Morphological and functional imaging in COPD with CT and MRI: present and future , 2008, European Radiology.

[28]  J. Repine,et al.  Detection of tobacco smoke deposition by hyperpolarized krypton-83 MRI. , 2008, Magnetic resonance imaging.

[29]  A. Sukstanskii,et al.  In vivo lung morphometry with hyperpolarized 3He diffusion MRI: theoretical background. , 2008, Journal of magnetic resonance.

[30]  Hiroto Hatabu,et al.  Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality? , 2007, European journal of radiology.

[31]  D. Mannino,et al.  Global burden of COPD: risk factors, prevalence, and future trends , 2007, The Lancet.

[32]  J. Brookeman,et al.  XTC MRI: Sensitivity improvement through parameter optimization , 2007, Magnetic resonance in medicine.

[33]  J. Wooten,et al.  Hyperpolarized 83Kr and 129Xe NMR relaxation measurements of hydrated surfaces: implications for materials science and pulmonary diagnostics. , 2007, Journal of the American Chemical Society.

[34]  Dmitriy A Yablonskiy,et al.  Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema , 2006, Magnetic resonance in medicine.

[35]  G Allan Johnson,et al.  Imaging alveolar–capillary gas transfer using hyperpolarized 129Xe MRI , 2006, Proceedings of the National Academy of Sciences.

[36]  M. Belvisi,et al.  IκB Kinase-2-Independent and -Dependent Inflammation in Airway Disease Models: Relevance of IKK-2 Inhibition to the Clinic , 2006, Molecular Pharmacology.

[37]  K. Stupic,et al.  Quadrupolar relaxation of hyperpolarized krypton-83 as a probe for surfaces. , 2006, Solid state nuclear magnetic resonance.

[38]  K. Stupic,et al.  Exploring hyperpolarized Kr83 by remotely detected NMR relaxometry , 2006 .

[39]  R. Basaraba,et al.  Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[40]  M. Belvisi,et al.  Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation. , 2005, American journal of respiratory and critical care medicine.

[41]  J. Shrager,et al.  Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging , 2005, Magnetic resonance in medicine.

[42]  John P Mugler,et al.  Exploring lung function with hyperpolarized 129Xe nuclear magnetic resonance , 2004, Magnetic resonance in medicine.

[43]  Dmitriy A Yablonskiy,et al.  Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[44]  M. Deschamps,et al.  Probing aerogels by multiple quantum filtered (131)Xe NMR spectroscopy. , 2001, Journal of the American Chemical Society.

[45]  C. Mao,et al.  Effects of all-trans-retinoic acid in promoting alveolar repair. , 2000, Chest.

[46]  S. Gibbs,et al.  Xenon-131 surface sensitive imaging of aerogels in liquid xenon near the critical point. , 1999, Journal of magnetic resonance.

[47]  F. Jolesz,et al.  Gradient-Echo Imaging Considerations for Hyperpolarized 129Xe MR , 1996, Journal of magnetic resonance. Series B.

[48]  D. Frazer,et al.  Trapped air in ventilated excised rat lungs. , 1976, Journal of applied physiology.

[49]  J. Hughes,et al.  Factors affecting trapped gas volume in perfused dog lungs. , 1970, Journal of applied physiology.

[50]  K. Stowman.  World health statistics. , 1949, The Milbank Memorial Fund quarterly.

[51]  G. Washko,et al.  Diffusion of hyperpolarized 129Xe in the lung: a simplified model of 129Xe septal uptake and experimental results , 2011 .

[52]  K. Stupic,et al.  Exploring hyperpolarized 83Kr by remotely detected NMR relaxometry. , 2006, The Journal of chemical physics.

[53]  John P Mugler,et al.  Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes--initial experience. , 2002, Radiology.

[54]  F A Jolesz,et al.  Gradient-echo imaging considerations for hyperpolarized 129Xe MR. , 1996, Journal of magnetic resonance. Series B.

[55]  L Zhao,et al.  Gradientecho imaging considerations for hyperpolarized ^ Xe MR , 1996 .

[56]  G. Snider,et al.  Animal models of emphysema. , 1978, The American review of respiratory disease.

[57]  C. Kuhn,et al.  The scanning electron microscopy of elastase-induced emphysema. A comparison with emphysema in man. , 1976, Laboratory investigation; a journal of technical methods and pathology.