Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy

Typical aging is associated with gradual cognitive decline and changes in brain structure. The observation that cognitive performance in mesial temporal lobe epilepsy (TLE) patients diverges from controls early in life with subsequent decline running in parallel would suggest an initial insult but does not support accelerated decline secondary to seizures. Whether TLE patients demonstrate similar trajectories of age‐related gray (GM) and white matter (WM) changes as compared to healthy controls remains uncertain.

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