R-isomers of Arg-Gly-Asp (RGD) mimics as potent αvβ3 inhibitors
暂无分享,去创建一个
D. Griggs | J. Malecha | J. Collins | M. A. Russell | T. E. Rogers | M. B. Finn | L. D. Marrufo | Melissa K. Lantz | Pegg Jodi Ann | Melanie L Williams | V. Engleman | G. Nickols | P. Ruminski | J. Keene | Jun Zhu | M. Nickols | Nagarajan Srinivasan | Devadas Balekudru | Hwang-Fun Lu | G. RicoJoseph | H. P. Kleine | Nawasa F. Green | B. Landis | L. Miller | D. Meyer | T. Duffin | S. K. Freeman | K. E. Shannon | C. Steininger | Marisa M. Westlin | M. Russell | T. Rogers | Kristen E. Shannon | James W. Malecha | Melanie L. Williams
[1] J. Debus,et al. Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy , 2005, Clinical Cancer Research.
[2] P. Colson,et al. Practical Enantioselective Synthesis of β-Substituted-β-amino Esters , 2005 .
[3] D. Griggs,et al. A small molecule antagonist of the αvβ3 integrin suppresses MDA-MB-435 skeletal metastasis , 2004, Clinical & Experimental Metastasis.
[4] T. Lectka,et al. A multistage, one-pot procedure mediated by a single catalyst: a new approach to the catalytic asymmetric synthesis of beta-amino acids. , 2003, The Journal of organic chemistry.
[5] L. Ellis,et al. αvβ3 Integrin Antagonist S247 Decreases Colon Cancer Metastasis and Angiogenesis and Improves Survival in Mice , 2003 .
[6] S. Mousa,et al. The αv integrin antagonists as novel anticancer agents: an update , 2002 .
[7] Richard O Hynes,et al. Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.
[8] P. Coleman,et al. Ligands to the integrin receptor αvβ3 , 2002 .
[9] B. Neustadt,et al. Inhibition of Angiogenesis and Tumor Growth by SCH221153, a Dual αvβ3 and αvβ5 Integrin Receptor Antagonist , 2001 .
[10] Stanley J. Wiegand,et al. Vascular-specific growth factors and blood vessel formation , 2000, Nature.
[11] P. Carmeliet,et al. Angiogenesis in cancer and other diseases , 2000, Nature.
[12] J. Hutchinson,et al. Ligands to the integrin receptor αvβ3 , 2000 .
[13] K. Ward,et al. Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic. , 2000, Journal of medicinal chemistry.
[14] R. Gould,et al. Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation. , 1999, Journal of medicinal chemistry.
[15] William F. Westlin,et al. A Peptidomimetic Antagonist of the Integrin αvβ3 Inhibits Leydig Cell Tumor Growth and the Development of Hypercalcemia of Malignancy , 1998 .
[16] M A Horton,et al. A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. , 1997, The Journal of clinical investigation.
[17] F. Sarkar,et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. , 1995, The Journal of clinical investigation.
[18] K. Williams,et al. Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp sequence of fibrinogen. (Aminobenzamidino)succinyl (ABAS) series of orally active fibrinogen receptor antagonists. , 1995, Journal of medicinal chemistry.
[19] J. Rico. Synthesis of novel β-amino acid precursors : β-amino-hydrocoumarins as unusual aspartic acid mimetics used in fibrinogen receptor antagonists , 1994 .
[20] R. Gould,et al. Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp. , 1994, Journal of medicinal chemistry.
[21] D. Cheresh,et al. Requirement of vascular integrin alpha v beta 3 for angiogenesis. , 1994, Science.
[22] R J Lynch,et al. Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. , 1992, Journal of medicinal chemistry.
[23] I. Charo,et al. Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide. , 1991, The Journal of biological chemistry.
[24] M. Hayashi,et al. Novel purification of vitronectin from human plasma by heparin affinity chromatography. , 1988, Cell structure and function.
[25] J. Koziol,et al. Increased surface expression of the membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation. , 1987, Blood.
[26] D. Griggs,et al. Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247 , 2004, Clinical & Experimental Metastasis.
[27] S. Mousa. MECHANISMS OF ANGIOGENESIS IN VASCULAR DISORDERS : POTENTIAL THERAPEUTIC TARGETS , 1998 .
[28] E. Ruoslahti,et al. [27] Arginine-glycine-aspartic acid adhesion receptors , 1987 .