Effect of microneedle treatment on the skin permeation of a nanoencapsulated dye

Objectives  The aim of the study was to investigate the effect of microneedle (MN) pretreatment on the transdermal delivery of a model drug (Rhodamine B, Rh B) encapsulated in polylactic‐co‐glycolic acid (PLGA) nanoparticles (NPs) focusing on the MN characteristics and application variables.

[1]  Kosmas Kretsos,et al.  A geometrical model of dermal capillary clearance. , 2007, Mathematical biosciences.

[2]  C. Shearwood,et al.  Transdermal microneedles for drug delivery applications , 2006 .

[3]  Tielin Shi,et al.  Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[4]  Wijaya Martanto,et al.  Mechanism of fluid infusion during microneedle insertion and retraction. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[5]  Ciprian Iliescu,et al.  Sonophoretic enhanced microneedles array (SEMA)—Improving the efficiency of transdermal drug delivery , 2010 .

[6]  Ryan F Donnelly,et al.  Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[7]  Young Bin Choy,et al.  A microneedle roller for transdermal drug delivery. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[8]  Xueying Ding,et al.  Combination of Microneedles with PLGA Nanoparticles as a Potential Strategy for Topical Drug Delivery , 2011 .

[9]  Jing Gao,et al.  Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles. , 2010, International journal of pharmaceutics.

[10]  Claus-Michael Lehr,et al.  Nanoparticles--an efficient carrier for drug delivery into the hair follicles. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[11]  J. Bouwstra,et al.  Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[12]  Stefan W. Hell,et al.  Aberrations in confocal and multi-photon fluorescence microscopy induced by refractive index mismatch , 2006 .

[13]  R H Guy,et al.  Skin penetration and distribution of polymeric nanoparticles. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[14]  R. Guy,et al.  Disposition of nanoparticles and an associated lipophilic permeant following topical application to the skin. , 2009, Molecular pharmaceutics.

[15]  S. Hackbarth,et al.  Investigation of Polylactic Acid (PLA) Nanoparticles as Drug Delivery Systems for Local Dermatotherapy , 2009, Pharmaceutical Research.

[16]  Desmond I. J. Morrow,et al.  Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers. , 2010, Photodiagnosis and photodynamic therapy.

[17]  P. Friden,et al.  Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate , 2008, The Journal of pharmacy and pharmacology.

[18]  Peter McLoughlin,et al.  Microneedle mediated delivery of nanoparticles into human skin. , 2009, International journal of pharmaceutics.

[19]  K. Sugibayashi,et al.  Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[20]  A. Banga,et al.  Enhanced transdermal delivery of low molecular weight heparin by barrier perturbation. , 2009, International journal of pharmaceutics.

[21]  V. Bhardwaj,et al.  Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[22]  Haripriya Kalluri,et al.  Formation and Closure of Microchannels in Skin Following Microporation , 2010, Pharmaceutical Research.

[23]  K. Papadopoulos,et al.  Improved dermal delivery of FITC-BSA using a combination of passive and active methods. , 2011, Journal of pharmaceutical sciences.

[24]  A. Banga,et al.  Molecular charge mediated transport of a 13 kD protein across microporated skin. , 2009, International journal of pharmaceutics.

[25]  P. Crooks,et al.  Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs. , 2010, Journal of pharmaceutical sciences.

[26]  M. C. Bonner,et al.  Transfollicular drug delivery--is it a reality? , 2005, International journal of pharmaceutics.

[27]  Mark R Prausnitz,et al.  Kinetics of skin resealing after insertion of microneedles in human subjects. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[28]  Michał R. Radowski,et al.  Influence of nanocarrier type and size on skin delivery of hydrophilic agents. , 2009, International journal of pharmaceutics.

[29]  H. Alpár,et al.  Potential use of nanoparticles for transcutaneous vaccine delivery: effect of particle size and charge. , 2004, International journal of pharmaceutics.

[30]  R. Guss,et al.  Rhodamine B as a test molecule in intraocular dynamics. , 1984, Investigative ophthalmology & visual science.

[31]  Wolfgang Becker,et al.  Nanoparticles and microparticles for skin drug delivery. , 2011, Advanced drug delivery reviews.

[32]  J. Pawley,et al.  Handbook of Biological Confocal Microscopy , 1990, Springer US.

[33]  W. Jiskoot,et al.  Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations , 2010, Pharmaceutical Research.

[34]  V. Meidan,et al.  Transepidermal water loss for probing full-thickness skin barrier function: correlation with tritiated water flux, sensitivity to punctures and diverse surfactant exposures. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[35]  Jie Zhang,et al.  Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery. , 2010, International journal of pharmaceutics.

[36]  F. Wang,et al.  Formulation of Nano and Micro PLGA Particles of the Model Peptide Insulin: Preparation, Characterization, Stability and Deposition in Human Skin , 2008 .

[37]  Mike Heilemann,et al.  Fluorescence microscopy beyond the diffraction limit. , 2010, Journal of biotechnology.

[38]  Hiroaki Todo,et al.  Transdermal drug delivery by in-skin electroporation using a microneedle array. , 2010, International journal of pharmaceutics.

[39]  A. Fahr,et al.  Skin penetration enhancement by a microneedle device (Dermaroller) in vitro: dependency on needle size and applied formulation. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[40]  Yuqin Qiu,et al.  Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[41]  L. Contreras,et al.  Human skin drug delivery using biodegradable PLGA-nanoparticles , 2007 .

[42]  Elly van Riet,et al.  Advances in transcutaneous vaccine delivery: do all ways lead to Rome? , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[43]  Juergen Lademann,et al.  Porcine ear skin: an in vitro model for human skin , 2007, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[44]  Zhengrong Cui,et al.  Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin , 2011, International journal of nanomedicine.

[45]  A. Banga,et al.  In vitro transdermal delivery of therapeutic antibodies using maltose microneedles. , 2009, International journal of pharmaceutics.

[46]  I. Chang,et al.  Transdermal delivery of mixnoxidil with block copolymer nanoparticles. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[47]  Sion A. Coulman,et al.  Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles. , 2006, Current drug delivery.

[48]  N. Nicolaides,et al.  The skin surface lipids of man compared with those of eighteen species of animals. , 1968, Journal of Investigative Dermatology.

[49]  Ryan F. Donnelly,et al.  Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety , 2010, Drug delivery.

[50]  Meirong Huo,et al.  Super-short solid silicon microneedles for transdermal drug delivery applications. , 2010, International journal of pharmaceutics.

[51]  J. Moan,et al.  Microneedle Pre-treatment of Human Skin Improves 5-Aminolevulininc Acid (ALA)- and 5-Aminolevulinic Acid Methyl Ester (MAL)-Induced PpIX Production for Topical Photodynamic Therapy Without Increase in Pain or Erythema , 2010, Pharmaceutical Research.

[52]  Jenny R. Roberts,et al.  Skin as a route of exposure and sensitization in chronic beryllium disease. , 2003, Environmental health perspectives.

[53]  Priyanka Ghosh,et al.  In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[54]  J. Bouwstra,et al.  Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[55]  Zhongping Chen,et al.  Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography , 2010, Biomedical optics express.