Phase I/II pilot study of intravesical apaziquone (EO9) for superficial bladder cancer.
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J. Beijnen | J. Double | P. Loadman | C. Twelves | R. Phillips | S. Chawla | G. Lenaz | C. V. van Kalken | M. Flannigan | S. Basu | T. Shah | R. Puri | V. Palit | M. Beer | R. D. de Boer | R. de Boer | G. A. Choudry
[1] P. Loadman,et al. Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: Relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy , 2004, International journal of cancer.
[2] P. Hoskin,et al. GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON , 2003, British Journal of Cancer.
[3] A. Harris,et al. GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding , 2003, International journal of cancer.
[4] M. Bibby,et al. Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9 , 2002, British journal of pharmacology.
[5] James B. Mitchell,et al. Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity. , 2002 .
[6] A. P. M. Meijden. The use of the marker tumor concept in Ta, T1 bladder cancer , 2002 .
[7] J. Brown,et al. A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9 , 2001, British Journal of Cancer.
[8] A. Harris,et al. The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions. , 2000, Biochemical pharmacology.
[9] P. Loadman,et al. Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. , 1998, British Journal of Cancer.
[10] A. te Velde,et al. EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group. , 1996, European journal of cancer.
[11] A. te Velde,et al. A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG). , 1996, Annals of Oncology.
[12] M. Grever,et al. Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. , 1996, Journal of the National Cancer Institute.
[13] P. Workman,et al. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9. , 1994, British Journal of Cancer.
[14] J. Verweij,et al. Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09. , 1994, Journal of the National Cancer Institute.
[15] G. Adams,et al. Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia. , 1994, European Journal of Cancer.
[16] M. Krishna,et al. Nitroxides as antioxidants. , 1994, Methods in enzymology.
[17] P. Workman,et al. Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. , 1994, Oncology research.
[18] J. Double,et al. EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models. , 1993, European journal of cancer.
[19] J. Double,et al. Factors affecting the in vitro dissolution of cobalt oxide. , 1992, British Journal of Cancer.