Electroencephalographic frontal asymmetry and depressive symptoms in the elderly

Although neurophysiological changes of aging are well known, there is still much to learn about cortical asymmetry in older depressed subjects. This study aimed at assessing differences between depressed and normal elderly subjects on alpha asymmetry, and to observe the correlations of this measure with depressive symptoms and quality of life. Thirty-six subjects (14 normal and 22 depressed) were assessed by EEG, depression rating scales, and SF-36. Despite the fact that compared to healthy elderly, depressive elderly subjects showed relatively greater right frontal activity (F4F3) and relatively greater left parietal activity (P4P3); this difference was not significant. The relationship between depression and frontal asymmetry was better observed in healthy elderly, where relatively greater left frontal activity was associated with less depressive symptoms.

[1]  R. Dishman,et al.  Brain electrocortical activity during and after exercise: a quantitative synthesis. , 2004, Psychophysiology.

[2]  Jeffrey B. Henriques,et al.  Left frontal hypoactivation in depression. , 1991, Journal of abnormal psychology.

[3]  S. Debener,et al.  Is Resting Anterior EEG Alpha Asymmetry a Trait Marker for Depression? , 2000, Neuropsychobiology.

[4]  J. Allen,et al.  Resting frontal electroencephalographic asymmetry in depression: inconsistencies suggest the need to identify mediating factors. , 1998, Psychophysiology.

[5]  R. Cabeza,et al.  Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction , 2002, Neuroscience & Biobehavioral Reviews.

[6]  N. Fox,et al.  Long-term stability of frontal electroencephalographic asymmetry in adults with a history of depression and controls. , 2006, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[7]  Nina Kraus,et al.  Aging Affects Hemispheric Asymmetry in the Neural Representation of Speech Sounds , 2000, The Journal of Neuroscience.

[8]  P. Ekman,et al.  Approach-withdrawal and cerebral asymmetry: emotional expression and brain physiology. I. , 1990, Journal of personality and social psychology.

[9]  Jeffrey B. Henriques,et al.  Frontal Brain Asymmetry and Reward Responsiveness , 2005, Psychological science.

[10]  Á. Pascual-Leone,et al.  Effects of antidepressant treatment with rTMS and fluoxetine on brain perfusion in PD , 2006, Neurology.

[11]  J. P. Kline,et al.  Gender specificity of resting anterior electroencephalographic asymmetry and defensiveness in the elderly. , 1999, The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia.

[12]  J. P. Kline,et al.  Can EEG asymmetry patterns predict future development of anxiety and depression? A preliminary study , 2006, Biological Psychology.

[13]  John J. B. Allen,et al.  Issues and assumptions on the road from raw signals to metrics of frontal EEG asymmetry in emotion , 2004, Biological Psychology.

[14]  C. Sherbourne,et al.  The MOS 36-Item Short-Form Health Survey (SF-36) , 1992 .

[15]  R. Davidson,et al.  Frontal brain activation in repressors and nonrepressors. , 1994, Journal of abnormal psychology.

[16]  Patrick E. McKnight,et al.  A capability model of individual differences in frontal EEG asymmetry , 2006, Biological Psychology.

[17]  Rozana Mesquita Ciconelli,et al.  Tradução para o português e validação do questionário genérico de avaliação de qualidade de vida medical outcomes study 36-item short-form health survey (SF-36) , 1997 .

[18]  Pearl H. Chiu,et al.  Cognitive restructuring and EEG in major depression , 2005, Biological Psychology.

[19]  Nicole Y. Weekes,et al.  The effect of a naturalistic stressor on frontal EEG asymmetry, stress, and health , 2007, Biological Psychology.

[20]  D. Hagemann,et al.  Individual differences in anterior EEG asymmetry: methodological problems and solutions , 2004, Biological Psychology.

[21]  R. Davidson.  Anterior cerebral asymmetry and the nature of emotion , 1992, Brain and Cognition.

[22]  Günter Schulter,et al.  Covariations of EEG asymmetries and emotional states indicate that activity at frontopolar locations is particularly affected by state factors. , 2002, Psychophysiology.

[23]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[24]  H. Calil,et al.  Depression Assessment in Brazil , 1987, British Journal of Psychiatry.

[25]  M. Åsberg,et al.  A New Depression Scale Designed to be Sensitive to Change , 1979, British Journal of Psychiatry.

[26]  F. Quitkin,et al.  Regional brain asymmetries in major depression with or without an anxiety disorder: A quantitative electroencephalographic study , 1997, Biological Psychiatry.

[27]  S. Petruzzello,et al.  Frontal asymmetry, dispositional affect, and physical activity in older adults , 1999 .

[28]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[29]  A. Takahashi.  Rating scale for depression , 1998 .

[30]  Arnaud Delorme,et al.  EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis , 2004, Journal of Neuroscience Methods.

[31]  J. P. Kline,et al.  The failed repressor: EEG asymmetry as a moderator of the relation between defensiveness and depressive symptoms. , 2008, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[32]  J. P. Kline,et al.  Anterior electroencephalographic asymmetry changes in elderly women in response to a pleasant and an unpleasant odor , 2000, Biological Psychology.

[33]  R. Raedt,et al.  Is the relationship between frontal EEG alpha asymmetry and depression mediated by implicit or explicit self-esteem? , 2008, Biological Psychology.

[34]  R. Davidson.  What does the prefrontal cortex “do” in affect: perspectives on frontal EEG asymmetry research , 2004, Biological Psychology.

[35]  Regional brain activation as a biological marker of affective responsivity to acute exercise: influence of fitness. , 2001 .

[36]  Sangmoon Kim,et al.  Depression, anxiety, and resting frontal EEG asymmetry: a meta-analytic review. , 2006, Journal of abnormal psychology.

[37]  R. Cabeza.  Hemispheric asymmetry reduction in older adults: the HAROLD model. , 2002, Psychology and aging.

[38]  L. Andrade,et al.  Validation of a Portuguese version of the Beck Depression Inventory and the State-Trait Anxiety Inventory in Brazilian subjects. , 1996, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[39]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[40]  J. P. Kline,et al.  Is left frontal brain activation in defensiveness gender specific? , 1998, Journal of abnormal psychology.

[41]  Heather L. Urry,et al.  The stability of resting frontal electroencephalographic asymmetry in depression. , 2004, Psychophysiology.

[42]  John J. B. Allen,et al.  Frontal EEG asymmetry as a moderator and mediator of emotion , 2004, Biological Psychology.

[43]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[44]  S. Shelton,et al.  Lateralized effects of diazepam on frontal brain electrical asymmetries in rhesus monkeys , 1992, Biological Psychiatry.

[45]  R. Davidson,et al.  Prefrontal Brain Asymmetry: A Biological Substrate of the Behavioral Approach and Inhibition Systems , 1997 .