The cytoskeleton and mRNA localization.

Abstract The localization of mRNA appears to facilitate protein sorting, so that proteins are synthesized in specific cellular regions. The spatial information on the mRNA may be transduced by proteins that recognize specific localizing sequences on the 3′ end and then chaperone the mRNA, presumably along filaments, to its destination. Additional sequences such as poly(A), or the nascent chains of cytoskeleton-associated proteins, may then anchor mRNAs on the cytoskeleton.

[1]  W. Jeffery,et al.  Localization of actin messenger RNA during early ascidian development. , 1983, Developmental biology.

[2]  E. Gottlieb.  Messenger RNA transport and localization. , 1990, Current opinion in cell biology.

[3]  S. Penman,et al.  Cytochalasin releases mRNA from the cytoskeletal framework and inhibits protein synthesis. , 1986, Molecular and cellular biology.

[4]  M. Waxham,et al.  In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[5]  P. Macdonald,et al.  oskar mRNA is localized to the posterior pole of the Drosophila oocyte , 1991, Cell.

[6]  M. Bjerknes,et al.  Asymmetric distribution of actin mRNA and cytoskeletal pattern generation in polarized epithelial cells. , 1989, Journal of molecular biology.

[7]  D. Melton,et al.  The maternal mRNA Vg1 is correctly localized following injection into Xenopus oocytes , 1988, Nature.

[8]  R. Lehmann,et al.  oskar organizes the germ plasm and directs localization of the posterior determinant nanos , 1991, Cell.

[9]  W. Isaacs,et al.  Cotranslational assembly of myosin heavy chain in developing cultured skeletal muscle. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Lenk,et al.  A cytoskeletal structure with associated polyribosomes obtained from HeLa cells , 1977, Cell.

[11]  O. Steward,et al.  Differential subcellular localization of particular mRNAs in hippocampal neurons in culture , 1990, Neuron.

[12]  D. Melton,et al.  A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. , 1990, Development.

[13]  Mark Ellisman,et al.  Subcellular localization of transcripts in Drosophila photoreceptor neurons: chaoptic mutants have an aberrant distribution. , 1990, Genes & development.

[14]  G. Struhl,et al.  Cis- acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos , 1988, Nature.

[15]  D Bopp,et al.  The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo. , 1988, The EMBO journal.

[16]  G. Stein,et al.  Multiple types of mRNA‐cytoskeleton interactions , 1990, Journal of cellular biochemistry.

[17]  R. Fremeau,et al.  Distinct spatial localization of specific mRNAs in cultured sympathetic neurons , 1990, Neuron.

[18]  D. Melton.  Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes , 1987, Nature.

[19]  J. Lawrence,et al.  Intracellular localization of messenger RNAs for cytoskeletal proteins , 1986, Cell.

[20]  Peter Walter,et al.  Protein translocation across the endoplasmic reticulum , 1984, Cell.

[21]  J. Lawrence,et al.  Ultrastructural visualization of cytoskeletal mRNAs and their associated proteins using double-label in situ hybridization , 1989, The Journal of cell biology.

[22]  Brenda R. Eisenberg,et al.  Distribution of myosin mRNA during development and regeneration of skeletal muscle fibers. , 1991, Developmental biology.

[23]  A. Matus,et al.  Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites , 1988, Nature.

[24]  D. Taylor,et al.  Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[25]  J. Lawrence,et al.  Spatial organization of nucleic acid sequences within cells. , 1991, Seminars in cell biology.

[26]  R. Steward,et al.  Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation , 1991, Cell.

[27]  J. Lawrence,et al.  Distribution of myosin heavy chain mRNA in embryonic muscle tissue visualized by ultrastructural in situ hybridization. , 1991, Developmental biology.

[28]  M. L. King,et al.  Localized maternal mRNA related to transforming growth factor beta mRNA is concentrated in a cytokeratin-enriched fraction from Xenopus oocytes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[29]  E C Stephenson,et al.  Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis. , 1991, Development.

[30]  B D Trapp,et al.  Spatial segregation of mRNA encoding myelin-specific proteins. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[31]  R. Singer,et al.  Requirement of microfilaments in sorting of actin messenger RNA. , 1991, Science.

[32]  I. Herman,et al.  Beta actin and its mRNA are localized at the plasma membrane and the regions of moving cytoplasm during the cellular response to injury , 1991, The Journal of cell biology.

[33]  D. Ish-Horowicz,et al.  Apical localization of pair-rule transcripts requires 3′ sequences and limits protein diffusion in the Drosophila blastoderm embryo , 1991, Cell.

[34]  P. Silver.  How proteins enter the nucleus , 1991, Cell.

[35]  J. Condeelis,et al.  Identification of an actin-binding protein from Dictyostelium as elongation factor 1a , 1990, Nature.

[36]  O. Steward,et al.  Selective dendritic transport of RNA in hippocampal neurons in culture , 1987, Nature.

[37]  W. Jeffery.  Localized mRNA and the egg cytoskeleton. , 1989, International review of cytology.

[38]  R. Singer,et al.  Actin mRNA localizes in the absence of protein synthesis , 1990, The Journal of cell biology.

[39]  Daniel St Johnston,et al.  staufen, a gene required to localize maternal RNAs in the Drosophila egg , 1991, Cell.

[40]  G. Dreyfuss,et al.  Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells , 1981, Cell.