Prostate cancer detection by laser induced autofluorescence and multicomponent spectroscopy

Laser-Induced-Autofluorescence (LIAF), White-Light-Remission (WLR) and Electrical-Impedance-Measurement (EIM) in combination with principal component analysis were used at first time for differentiation benign from malignant prostatic tissue in vitro. The used complex statistical processing of the data has shown a differentiation of benign and malignant prostatic tissue with a sensitivity of 93.8% and a specificity of 92.4%.

[1]  Laurence Lovat,et al.  Elastic scattering spectroscopy for detection of dysplasia in Barrett's esophagus. , 2004, Gastrointestinal endoscopy clinics of North America.

[2]  Nirmala Ramanujam,et al.  Optimal methods for fluorescence and diffuse reflectance measurements of tissue biopsy samples , 2002, Lasers in surgery and medicine.

[3]  T Iritani,et al.  A study of the electrical bio-impedance of tumors. , 1993, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[4]  R. Anderson,et al.  Electrical impedance scanning: a new technique in the diagnosis of lymph nodes in which malignancy is suspected on ultrasound. , 2001, The British journal of radiology.

[5]  S. Majumder,et al.  N2 laser excited autofluorescence spectroscopy of formalin-fixed human breast tissue. , 2005, Journal of photochemistry and photobiology. B, Biology.

[6]  M. Graefen,et al.  Open retropubic nerve-sparing radical prostatectomy. , 2006, European urology.

[7]  G. Andriole,et al.  Do Margins Matter? The Prognostic Significance of Positive Surgical Margins in Radical Prostatectomy Specimens , 2008 .

[8]  David Gur,et al.  Electrical impedance scanning for the early detection of breast cancer in young women: preliminary results of a multicenter prospective clinical trial. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  R. Rava,et al.  SPECTROSCOPIC DIAGNOSIS OF COLONIC DYSPLASIA , 1991, Photochemistry and photobiology.

[10]  W. Ruka,et al.  Fluorescence in situ detection of human cutaneous melanoma: study of diagnostic parameters of the method. , 2001, The Journal of investigative dermatology.

[11]  O. Cussenot,et al.  Laser induced autofluorescence diagnosis of bladder tumors: dependence on the excitation wavelength. , 1996, The Journal of urology.

[12]  P. Gupta,et al.  Measurement of NADH concentration in normal and malignant human tissues from breast and oral cavity , 2003, Biotechnology and applied biochemistry.

[13]  T. Boehm,et al.  Electrical impedance scanning for classifying suspicious breast lesions: first results , 2000, European Radiology.

[14]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[15]  Ehsan Gazi,et al.  A correlation of FTIR spectra derived from prostate cancer biopsies with gleason grade and tumour stage. , 2006, European urology.

[16]  C. Kendall,et al.  Optical diagnostics in urology: current applications and future prospects , 2003, BJU international.

[17]  N. Chauveau,et al.  In vitro tissue characterization and modelling using electrical impedance measurements in the 100 Hz-10 MHz frequency range. , 1995, Physiological measurement.

[18]  B. Blad,et al.  Impedance spectra of tumour tissue in comparison with normal tissue; a possible clinical application for electrical impedance tomography. , 1996, Physiological measurement.

[19]  N. Ramanujam.  Fluorescence spectroscopy of neoplastic and non-neoplastic tissues. , 2000, Neoplasia.

[20]  M F Mitchell,et al.  Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix. , 1999, Obstetrics and gynecology.

[21]  Hartwig Huland,et al.  Frozen section for the management of intraoperatively detected palpable tumor lesions during nerve-sparing scheduled radical prostatectomy. , 2006, European urology.

[22]  N. Kalia,et al.  Virtual Biopsies in Barrett's Esophagus Using an Impedance Probe , 1999, Annals of the New York Academy of Sciences.

[23]  R. Miller,et al.  Increased tight junctional permeability is associated with the development of colon cancer. , 1999, Carcinogenesis.

[24]  M Motamedi,et al.  Brain tumor demarcation using optical spectroscopy; an in vitro study. , 2000, Journal of biomedical optics.

[25]  R. Richards-Kortum,et al.  Optimal Excitation Wavelengths for In Vivo Detection of Oral Neoplasia Using Fluorescence Spectroscopy¶ , 2000, Photochemistry and photobiology.

[26]  M. Kattan,et al.  Prognostic impact of positive surgical margins in surgically treated prostate cancer: multi-institutional assessment of 5831 patients. , 2005, Urology.

[27]  W. Webb,et al.  Conformational Dependence of Intracellular NADH on Metabolic State Revealed by Associated Fluorescence Anisotropy*♦ , 2005, Journal of Biological Chemistry.

[28]  J. Epstein.  Incidence and significance of positive margins in radical prostatectomy specimens. , 1996, The Urologic clinics of North America.