Computer simulation of the Human pituitary-ovarian cycle: studies of follicular phase estradiol infusions and the midcycle peak.

A mathematical model of the hormonal changes during the pituitary-ovarian cycle has been developed based on the previous model of Bogumil et al. Our model incorporates the following distinctive features: 1) discontinuous pulsatile secretion of luteinizing hormone (LH), with regulation of its production rate dependent on both the size and frequency of pulsations; 2) the midcycle LH surge (and FSH surge) are triggered by a significant fall of serum estradiol (E2) after E2 has been maintained at a high level for a critical period of time; 3) the magnitude of the LH and FSH surges depends on the dose and duration of E2 in the antecedent follicular phase; 4) the sensitivity of the pituitary to E2 feedback changes during the follicular phase, i.e., low E2 during the early follicular phase provides a stimulus for increased LH release in the mid-follicular phase; 5) effects of LH and FSH on the ovary are manifested only after an arbitrary delay; 6) LH is metabolized in a two compartment rather than a single compa...

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