Cytophilic Fluorescent Bioprobes for Long‐Term Cell Tracking

Fluorescence (FL) bioprobes have made important contributions to advancing our knowledge in life science, due to their unrivaled ability to image and monitor biological structures and processes in the living systems. [ 1,2 ] Typical materials used as biosensors include natural polymers, inorganic nanoparticles, and organic dyes. Green fl uorescent protein (GFP), for example, has been used as a reporter of expression for morphological differentiation. [ 1 ] The biosensing process, however, is realized through complicated yet time-consuming transfection procedures, which can lead to unexpected morphologies and undesired abnormality in the target cells. Inorganic nanoparticles, such as quantum dots (QDs), are highly luminescent and resistant to photobleaching but limited in variety and inherently toxic to living cells because QDs are commonly made of heavy metals and chalcogens (e.g., CdSe and PbS). [ 1,2 ]

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