MicroRNA and cancer – focus on apoptosis

•  Introduction •  miR biogenesis •  miR and Cancer •  miR and Apoptosis ‐  The pro‐apoptotic miRs targeting the BCL2 family of genes ‐  The anti‐apoptotic miR‐21 targets PTEN and PDCD4 ‐  miR‐210 decreases proapoptotic signalling in a hypoxic environment ‐  Let‐7/miR‐98 family and possible co‐operation with miR‐21 ‐  miR‐17–92 cluster highlights the complexity of miR regulatory networks ‐  miR‐224, the double‐edged sword ‐  Other miRs implicated in apoptosis •  Conclusion

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