Rapid accumulation of genome rearrangements in liver but not in brain of old mice

[1]  F. Gruijl,et al.  Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition , 1997, Cell.

[2]  S. Austad,et al.  Genetic analysis of ageing: role of oxidative damage and environmental stresses , 1996, Nature Genetics.

[3]  T. Kaneko,et al.  Non-linear accumulation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidized DNA damage, during aging. , 1996, Mutation research.

[4]  G. Schellenberg,et al.  Positional Cloning of the Werner's Syndrome Gene , 1996, Science.

[5]  J. Vijg,et al.  Plasmid-based transgenic mouse model for studying in vivomutations , 1995, Nature.

[6]  J. Vijg,et al.  Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model. , 1995, Mutation research.

[7]  H. Joenje,et al.  Mutagenicity of metabolic oxygen radicals in mammalian cell cultures. , 1994, Carcinogenesis.

[8]  B. Ames,et al.  Oxidants, antioxidants, and the degenerative diseases of aging. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[9]  J. Vijg,et al.  DNA sequence analysis of spontaneous mutations at a LacZ transgene integrated on the mouse X chromosome. , 1993, Mutagenesis.

[10]  J. Vijg,et al.  Application of galactose-sensitive E. coli strains as selective hosts for LacZ- plasmids. , 1992, Nucleic acids research.

[11]  B. Ames,et al.  Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[12]  R. Monnat,et al.  Mutator phenotype of Werner syndrome is characterized by extensive deletions. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[13]  E. Mullaart,et al.  Age-dependent accumulation of alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells , 1988, Mechanisms of Ageing and Development.

[14]  L. Recio,et al.  Evidence for reactive oxygen species inducing mutations in mammalian cells. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[15]  G. Failla.  The aging process and cancerogenesis. , 1958 .

[16]  J. Vijg,et al.  Bacteriophage Lambda and Plasmid lacZ Transgenic Mice for Studying Mutations in Vivo , 1996 .

[17]  J. Vijg,et al.  Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations. , 1996, Mutagenesis.

[18]  G. Pfeifer.  Technologies for Detection of DNA Damage and Mutations , 1996, Springer US.

[19]  R. Bronson,et al.  Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. , 1991, Growth, development, and aging : GDA.

[20]  E. Mullaart,et al.  Spontaneous DNA breaks in the rat brain during development and aging. , 1990, Mutation research.

[21]  D. Harrison,et al.  Physiological assays for biological age in mice: relationship of collagen, renal function, and longevity. , 1983, Experimental aging research.

[22]  L. Szilard.  ON THE NATURE OF THE AGING PROCESS. , 1959, Proceedings of the National Academy of Sciences of the United States of America.