Transcriptional Regulation of a BMP‐6 Promoter by Estrogen Receptor α

The effects of 17β‐estradiol (E2) and ICI 182,780 (ICI) on activity of a BMP‐6 promoter were compared in osteoblast‐like and breast cancer cells transiently transfected with ERα. E2 but not ICI stimulated BMP‐6 reporter activity in breast cancer cells, whereas the opposite was observed in osteoblast‐like cells, associated with lack of AF‐2 dependence of the response, and absent intranuclear localization of ERα, suggesting the involvement of a distinct ERα‐dependent response mechanism in osteoblasts.

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