Magnetoencapsulated human islets xenotransplanted into swine: a comparison of different transplantation sites

The fate of magnetically labeled, barium‐gelled alginate/protamine sulfate/alginate microcapsules (APSA magnetocapsules) following xenotransplantation was assessed by magnetic resonance imaging (MRI) and histopathology.

[1]  Clifford R. Weiss,et al.  Automated detection and characterization of SPIO‐labeled cells and capsules using magnetic field perturbations , 2012, Magnetic resonance in medicine.

[2]  D. Arifin,et al.  Use of Magnetocapsules for In Vivo Visualization and Enhanced Survival of Xenogeneic HepG2 Cell Transplants. , 2012, Cell medicine.

[3]  Ames,et al.  Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen , 2000 .

[4]  MR-guided portal vein delivery and monitoring of magnetocapsules: assessment of physiologic effects on the liver. , 2011, Journal of vascular and interventional radiology : JVIR.

[5]  P. de Vos,et al.  A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells , 2014, Scientific Reports.

[6]  W. D’hoore,et al.  Parameters favouring successful adult pig islet isolations for xenotransplantation in pig‐to‐primate models , 2006, Xenotransplantation.

[7]  P. de Vos,et al.  Polymers in cell encapsulation from an enveloped cell perspective. , 2014, Advanced drug delivery reviews.

[8]  D. Arifin,et al.  Trimodal gadolinium-gold microcapsules containing pancreatic islet cells restore normoglycemia in diabetic mice and can be tracked by using US, CT, and positive-contrast MR imaging. , 2011, Radiology.

[9]  Nathaniel K. Chan,et al.  Efficacy comparison between intraportal and subcapsular islet transplants in a murine diabetic model. , 2009, Transplantation proceedings.

[10]  J. Sentementes,et al.  Immune Privilege of the Testis for Islet Xenotransplantation (Rat to Mouse) , 1994, Cell transplantation.

[11]  C. Ricordi,et al.  Reversal of Diabetes by Pancreatic Islet Transplantation into a Subcutaneous, Neovascularized Device , 2006, Transplantation.

[12]  K. Jang,et al.  Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic mice , 2014, Experimental & Molecular Medicine.

[13]  Govind Bhagat,et al.  Islet Grafting and Imaging in a Bioengineered Intramuscular Space , 2009, Transplantation.

[14]  F. Lim,et al.  Microencapsulated islets as bioartificial endocrine pancreas. , 1980, Science.

[15]  W. Hawthorne,et al.  Pre‐clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes , 2011, Xenotransplantation.

[16]  R. Bottino,et al.  Long‐Term Controlled Normoglycemia in Diabetic Non‐Human Primates After Transplantation with hCD46 Transgenic Porcine Islets , 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[17]  O. Korsgren,et al.  Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes , 2000, Upsala journal of medical sciences.

[18]  H. Iwata,et al.  Long‐Term Allogeneic Islet Graft Survival in Prevascularized Subcutaneous Sites Without Immunosuppressive Treatment , 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[19]  D. Arifin,et al.  Microcapsules with intrinsic barium radiopacity for immunoprotection and X-ray/CT imaging of pancreatic islet cells. , 2012, Biomaterials.

[20]  R. Calafiore,et al.  Clinical application of microencapsulated islets: actual prospectives on progress and challenges. , 2014, Advanced drug delivery reviews.

[21]  U. Christians,et al.  Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates , 2006, Nature Medicine.

[22]  P. de Vos,et al.  Immunological and Technical Considerations in Application of Alginate-Based Microencapsulation Systems , 2014, Front. Bioeng. Biotechnol..

[23]  B. Hering,et al.  First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Executive summary , 2016, Xenotransplantation.

[24]  S. Matsumoto,et al.  Clinical porcine islet xenotransplantation under comprehensive regulation. , 2014, Transplantation proceedings.

[25]  P. de Vos,et al.  Chemistry and the biological response against immunoisolating alginate-polycation capsules of different composition. , 2006, Biomaterials.

[26]  Philippe Morel,et al.  International trial of the Edmonton protocol for islet transplantation. , 2006, The New England journal of medicine.

[27]  A. B. Stewart,et al.  Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons , 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[28]  F. Pattou,et al.  Islet Survival and Function Following Intramuscular Autotransplantation in the Minipig , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[29]  D. Sachs,et al.  Vascularized islet-cell transplantation in miniature swine. I. Preparation of vascularized islet kidneys , 2002, Transplantation.

[30]  Matthias Stuber,et al.  Magnetic resonance–guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells , 2007, Nature Medicine.

[31]  M. Inoue,et al.  Survival of Subretinal Pancreatic Islet Cell Allografts and Apoptosis in Infiltrating Lymphocytes in Rats , 2004, Ophthalmic Research.

[32]  J. Pedraz,et al.  Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy. , 2006, Biomaterials.

[33]  E. Dolgin Encapsulate this , 2014, Nature Medicine.

[34]  Y. Tabata,et al.  Bioartificial Pancreas Transplantation at Prevascularized Intermuscular Space: Effect of Angiogenesis Induction on Islet Survival , 2003, Pancreas.

[35]  D. Arifin,et al.  Synthesis of magnetic resonance–, X-ray– and ultrasound-visible alginate microcapsules for immunoisolation and noninvasive imaging of cellular therapeutics , 2011, Nature Protocols.

[36]  Denis Dufrane,et al.  Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates up to 6 Months Without Immunosuppression , 2010, Transplantation.

[37]  H. Dawson A Comparative Assessment of the Pig, Mouse and Human Genomes: Structural and Functional Analysis of Genes Involved in Immunity and Inflammation , 2011 .

[38]  B. Hering,et al.  Factors Affecting Transplant Outcomes in Diabetic Nude Mice Receiving Human, Porcine, and Nonhuman Primate Islets: Analysis of 335 Transplantations , 2013, Transplantation.

[39]  W. Hawthorne,et al.  Subcapsular Fetal Pig Pancreas Fragment Transplantation Provides Normal Blood Glucose Control in a Preclinical Model of Diabetes , 2011, Transplantation.

[40]  Á. Meana,et al.  Plasma-fibroblast gel as scaffold for islet transplantation. , 2009, Tissue engineering. Part A.

[41]  D. Sachs,et al.  Assessing the Effect of Immunosuppression on Engraftment of Pancreatic Islets , 2013, Transplantation.

[42]  D. Kraitchman,et al.  X‐Ray‐Visible Microcapsules Containing Mesenchymal Stem Cells Improve Hind Limb Perfusion in a Rabbit Model of Peripheral Arterial Disease , 2012, Stem cells.

[43]  E. Opara,et al.  Immunoisolation techniques for islet cell transplantation , 2002, Expert opinion on biological therapy.

[44]  L. Yahia,et al.  Biocompatibility and physicochemical characteristics of alginate-polycation microcapsules. , 2011, Acta biomaterialia.

[45]  Clifford R Weiss,et al.  MR‐guided biopsy: A review of current techniques and applications , 2008, Journal of magnetic resonance imaging : JMRI.

[46]  Denis Dufrane,et al.  Six-Month Survival of Microencapsulated Pig Islets and Alginate Biocompatibility in Primates: Proof of Concept , 2006, Transplantation.

[47]  Gorka Orive,et al.  Encapsulate this: the do's and don'ts , 2014, Nature Medicine.

[48]  D. Sachs,et al.  Vascularized islet cell transplantation in miniature Swine: islet-kidney allografts correct the diabetic hyperglycemia induced by total pancreatectomy. , 2002, Diabetes.

[49]  A. Tobar,et al.  Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model , 2009, Proceedings of the National Academy of Sciences.