SIMULATING BIORESORBABLE LATTICE STRUCTURES TO ENABLE TIME-DEPENDENT STIFFNESS IN FRACTURE FIXATION DEVICES

Abstract Additive manufacture (AM) enables a greatly increased design freedom owing to its ability to manufacture otherwise difficult or impossible geometries. However, design creativity can often present itself as a barrier to realising the advantages that AM could offer. In this study the use of AM, bioresorbable materials and lattice design is considered as a method of satisfying contradicting design requirements during fracture healing. Often, immediately after a fracture high stiffness fixation is required; contradictingly during the remodelling phase high stiffness can inhibit bone healing. This study proposes the use of a bioresorbable body centred cubic (BCC) or face centred cubic (FCC) lattice structure to meet the need for tailored variation in implant stiffness over time. To reduce computational expense of lattice modelling a method is outlined, including the use of homogenisation. Results show homogenised representations perform within 5.2% and 1.4% for BCC and FCC unit cells respectively, with a 95% reduction in computational expense. Using resorption rates from the literature, time-dependent change in unit cell geometry was also modelled, showing the way in which a decrease in stiffness over time could be achieved.

[1]  R. Ritchie,et al.  Architected cellular materials: A review on their mechanical properties towards fatigue-tolerant design and fabrication , 2021, Materials Science and Engineering: R: Reports.

[2]  P. Augat,et al.  The role of mechanical stimulation in the enhancement of bone healing. , 2020, Injury.

[3]  D. Constantinescu,et al.  Lattice structure optimization and homogenization through finite element analyses , 2020 .

[4]  M. Brandt,et al.  Effect of additive manufactured lattice defects on mechanical properties: an automated method for the enhancement of lattice geometry , 2020 .

[5]  Yufeng Zheng,et al.  Additive manufacturing of biodegradable Zn-xWE43 porous scaffolds: Formation quality, microstructure and mechanical properties , 2019, Materials & Design.

[6]  Yufeng Zheng,et al.  Additive manufacturing of biodegradable metals: Current research status and future perspectives. , 2019, Acta biomaterialia.

[7]  Abdulaziz A. Alghyamah,et al.  Biocompatible polymers and their potential biomedical applications: A review. , 2019, Current pharmaceutical design.

[8]  Jack G. Zhou,et al.  In vivo study of the efficacy, biosafety, and degradation of a zinc alloy osteosynthesis system. , 2019, Acta biomaterialia.

[9]  Miguel Fernandez-Vicente,et al.  Design Principles to Increase the Patient Specificity of High Tibial Osteotomy Fixation Devices , 2019, Proceedings of the Design Society: International Conference on Engineering Design.

[10]  Tahseen A. Alwattar,et al.  Development of an Elastic Material Model for BCC Lattice Cell Structures Using Finite Element Analysis and Neural Networks Approaches , 2019, Journal of Composites Science.

[11]  Peter D. Dunning,et al.  Development of an ABAQUS plugin tool for periodic RVE homogenisation , 2019, Engineering with Computers.

[12]  Zhizhou Zhang,et al.  Developments in 4D-printing: a review on current smart materials, technologies, and applications , 2019, International Journal of Smart and Nano Materials.

[13]  M. Dargusch,et al.  The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review. , 2019, Acta biomaterialia.

[14]  R. Poprawe,et al.  Laser additive manufacturing of Zn metal parts for biodegradable applications: Processing, formation quality and mechanical properties , 2018, Materials & Design.

[15]  S. Kenzari,et al.  Stress Concentration and Mechanical Strength of Cubic Lattice Architectures , 2018, Materials.

[16]  Peter Augat,et al.  Evolution of fracture treatment with bone plates. , 2018, Injury.

[17]  A. Schroeder,et al.  Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems. , 2018, Chemical engineering journal.

[18]  J. Drelich,et al.  Zinc-based alloys for degradable vascular stent applications. , 2018, Acta biomaterialia.

[19]  S. Saptarshi,et al.  Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications , 2017, Scientific Reports.

[20]  S. Saptarshi,et al.  Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications , 2017, Scientific Reports.

[21]  S. Natarajan,et al.  A review of the scaled boundary finite element method for two-dimensional linear elastic fracture mechanics , 2017 .

[22]  Mythili Prakasam,et al.  Biodegradable Materials and Metallic Implants—A Review , 2017, Journal of functional biomaterials.

[23]  R. Hague,et al.  Mechanical Properties of Ti-6Al-4V Selectively Laser Melted Parts with Body-Centred-Cubic Lattices of Varying cell size , 2015, Experimental Mechanics.

[24]  Damiano Pasini,et al.  Mechanical properties of lattice materials via asymptotic homogenization and comparison with alternative homogenization methods , 2013 .

[25]  D. Hak,et al.  The influence of fracture fixation biomechanics on fracture healing. , 2010, Orthopedics.

[26]  Frank Witte,et al.  The history of biodegradable magnesium implants: a review. , 2010, Acta biomaterialia.

[27]  C. Krettek,et al.  Effect of mechanical stability on fracture healing--an update. , 2007, Injury.

[28]  D. Caillerie,et al.  Continuous modeling of lattice structures by homogenization , 1998 .

[29]  Prashanth Thanigaiarasu,et al.  Biomimetics in the design of medical devices , 2020 .

[30]  Kahraman G. Demir,et al.  Developments in 4 D-printing : a review on current smart materials , technologies , and applications , 2019 .

[31]  Bernd Markert,et al.  Efficient numerical modeling of 3D-printed lattice-cell structures using neural networks , 2018 .

[32]  H. Hermawan Biodegradable Metals: State of the Art , 2012 .