Effect of staggered dose of calcium on the bioavailability of ciprofloxacin

The effect on ciprofloxacin's bioavailability (F) of calcium carbonate given 2 h before ciprofloxacin administration in 12 male volunteers was studied. The relative F with calcium was 0.98, maximum concentration of drug in serum increased significantly from 1.98 to 2.42 mg/liter (P = 0.039), and time to maximum concentration of drug in serum decreased from 1.82 to 1.26 h (P = 0.038). Thus, a single calcium carbonate dose, administered 2 h before ciprofloxacin, does not alter the F of this quinolone.

[1]  J. Wilton,et al.  Inhibition of norfloxacin absorption by antacids , 1990, Antimicrobial Agents and Chemotherapy.

[2]  W. Watson,et al.  The Effect of Sucralfate Pretreatment on the Pharmacokinetics of Ciprofloxacin , 1989, Pharmacotherapy.

[3]  E. Racht,et al.  Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers , 1989, Antimicrobial Agents and Chemotherapy.

[4]  T. Lesar,et al.  Concurrent administration of ciprofloxacin and potentially interacting drugs. , 1989, American journal of hospital pharmacy.

[5]  Jerome J. Schentag,et al.  Sucralfate reduces the gastrointestinal absorption of norfloxacin , 1989, Antimicrobial Agents and Chemotherapy.

[6]  S. Kobrin,et al.  Variable Efficacy of Calcium Carbonate Tablets , 1988, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[7]  F. Maggiolo,et al.  Antacids and ciprofloxacin pharmacokinetics , 1988, Antimicrobial Agents and Chemotherapy.

[8]  G. Drusano,et al.  Effect of dose size on bioavailability of ciprofloxacin , 1987, Antimicrobial Agents and Chemotherapy.

[9]  S. Segev,et al.  Drug interactions of ciprofloxacin with other non-antibiotic agents. , 1987, The American journal of medicine.

[10]  L. Preheim,et al.  CIPROFLOXACIN AND ANTACIDS , 1986, The Lancet.

[11]  B. Joos,et al.  Comparison of high-pressure liquid chromatography and bioassay for determination of ciprofloxacin in serum and urine , 1985, Antimicrobial Agents and Chemotherapy.

[12]  R. Wise,et al.  Pharmacokinetics and tissue penetration of ciprofloxacin , 1983, Antimicrobial Agents and Chemotherapy.

[13]  C. Rich,et al.  The absorption of calcium carbonate. , 1967, Annals of internal medicine.