Alteration of The Voltage-dependence of the Twitch Tension in Frog Skeletal Muscle Fibres by a Polyether, Bistramide A

Bistramide A, a toxin isolated from Lissochnum bistratum Sluiter, was applied to frog skeletal muscle fibres. Micromolar concentrations of toxin de­ creased the amplitude of the twitch tension. Bistramide A shifted the activa­ tion and the steady-state inactivation characteristics of the tension on the voltage axis towards more positive and negative membrane potentials respectively. The data suggest that Bistramide A binds to the activated and inactivated state of the dihydropyridine-receptor which senses the T-tubule membrane potential.

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