Dermatofibromas skin lesions seen in a dermatology practice. They are well circumscribed, solitary or multiple, usually hyperpigmented dermal nodules, typically less than 1 cm in diameter. They may be slightly protuberant, but are most often flat, and are generally located on the extremities. One of the clinical attributes of dermatofibromas is their persistency, as they undergo few changes, if any, along a course of many years. The little variability of fully evolved dermatofibromas is the reason why in practice they are seldom excised, unless excision is requested by the patient for cosmetic or other reasons. The frequency of their presentation does not imply, however, that we fully understand their nature (neoplasia vs reactive process), their cell of origin (dermal histiocyte vs fibroblast), or their relationship with other dermal tumors. Proof of this ambivalence is the multiple synonyms used to describe them, including dermatofibroma, histiocytoma cutis , or fibrous histiocy-toma, as well as the now less frequently used nodular
[1]
C. Miller,et al.
Cholesterotic fibrous histiocytoma. Its association with hyperlipoproteinemia.
,
1990,
Archives of dermatology.
[2]
C. Mattacks,et al.
DERMATOFIBROMAS AND ARTHROPOD BITES: IS THERE ANY EVIDENCE TO LINK THE TWO?
,
1989,
The Lancet.
[3]
M. Enjoji,et al.
Juvenile xanthogranuloma clinicopathologic analysis and immunohistochemical study of 57 patients
,
1985,
Cancer.
[4]
Jean Kanitakis,et al.
Immunohistologic study of cellular populations of histiocytofibromas („dermatofibromas”)
,
1984,
Journal of cutaneous pathology.
[5]
M. Kyriakos,et al.
Aneurysmal (“Angiomatoid”) fibrous histiocytoma of the skin
,
1981,
Cancer.