Influence of defined incompatibilities and area of burn on skin-homograft survival in burned-subjects.

Abstract BALB/c and C3H skin grafts were applied to CBA mice, which had been subjected to full-skin thickness burns of 15-35% total surface area. Observations were also made on the survival of HL-A compatible and incompatible skin grafts in severely burned patients. Graft survival was prolonged in burned hosts, and the prolongation depended on the extent of burning and on the genetic disparity between donor and host.