Chronometric features of processing unpleasant stimuli: a functional MRI-based transcranial magnetic stimulation study

The quick identification of potentially threatening events is a crucial cognitive capacity to survive in a changing environment. Previous functional MRI data revealed the right dorsolateral prefrontal cortex and the region of the left intraparietal sulcus (IPS) to be involved in the perception of emotionally negative stimuli. For assessing chronometric aspects of emotion processing, we applied transcranial magnetic stimulation above these areas at different times after negative and neutral picture presentation. An interference with emotion processing was found with transcranial magnetic stimulation above the dorsolateral prefrontal cortex 200–300 ms and above the left intraparietal sulcus 240/260 ms after negative stimuli. The data suggest a parallel and conjoint involvement of prefrontal and parietal areas for the identification of emotionally negative stimuli.

[1]  Lutz Jäncke,et al.  Modulation of corticospinal activity by strong emotions evoked by pictures and classical music: a transcranial magnetic stimulation study , 2007, Neuroreport.

[2]  Henrik Walter,et al.  Expecting unpleasant stimuli – An fMRI study , 2007, Psychiatry Research: Neuroimaging.

[3]  Henrik Walter,et al.  Side Effects of Transcranial Magnetic Stimulation Biased Task Performance in a Cognitive Neuroscience Study , 2005, Brain Topography.

[4]  M Gangitano,et al.  Chronometry of parietal and prefrontal activations in verbal working memory revealed by transcranial magnetic stimulation , 2003, NeuroImage.

[5]  K. Luan Phan,et al.  Functional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRI , 2002, NeuroImage.

[6]  Axel Thielscher,et al.  Spatial congruence of neuronavigated transcranial magnetic stimulation and functional neuroimaging , 2002, Clinical Neurophysiology.

[7]  R. Davidson.  Anxiety and affective style: role of prefrontal cortex and amygdala , 2002, Biological Psychiatry.

[8]  N. Sadato,et al.  Attention to emotion modulates fMRI activity in human right superior temporal sulcus. , 2001, Brain research. Cognitive brain research.

[9]  C Caltagirone,et al.  Parieto-frontal interactions in visual-object and visual-spatial working memory: evidence from transcranial magnetic stimulation. , 2001, Cerebral cortex.

[10]  M. Raichle,et al.  The Emotional Modulation of Cognitive Processing: An fMRI Study , 2000, Journal of Cognitive Neuroscience.

[11]  Karl J. Friston,et al.  Brain Mechanisms for Detecting Perceptual, Semantic, and Emotional Deviance , 2000, NeuroImage.

[12]  Leslie G. Ungerleider,et al.  Mechanisms of visual attention in the human cortex. , 2000, Annual review of neuroscience.

[13]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[14]  Joaquín M. Fuster,et al.  Executive frontal functions , 2000, Experimental Brain Research.

[15]  E. D. Haan,et al.  Laterality effects in selective attention to threat after repetitive transcranial magnetic stimulation at the prefrontal cortex in female subjects , 2000, Neuroscience Letters.

[16]  L. Parsons,et al.  Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. , 1999, The American journal of psychiatry.

[17]  R. Davidson,et al.  The functional neuroanatomy of emotion and affective style , 1999, Trends in Cognitive Sciences.

[18]  S. Rauch,et al.  Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge , 1998, The Journal of Neuroscience.

[19]  F Tecchio,et al.  The role of cutaneous inputs during magnetic transcranial stimulation , 1996, Muscle & nerve.

[20]  P. Lang.  The emotion probe. Studies of motivation and attention. , 1995, The American psychologist.

[21]  Gilles Pourtois,et al.  Dynamics of emotional effects on spatial attention in the human visual cortex. , 2006, Progress in brain research.

[22]  Uwe Herwig,et al.  Using the International 10-20 EEG System for Positioning of Transcranial Magnetic Stimulation , 2004, Brain Topography.

[23]  A. Cowey,et al.  Tickling the brain: studying visual sensation, perception and cognition by transcranial magnetic stimulation. , 2001, Progress in brain research.

[24]  J. C. Rothwell,et al.  Transcranial magnetic stimulation of medial–frontal cortex impairs the processing of angry facial expressions , 2001, Nature Neuroscience.

[25]  Alan Cowey,et al.  Chapter 26 Tickling the brain: studying visual sensation, perception and cognition by transcranial magnetic stimulation , 2001 .

[26]  Joseph E LeDoux.  Emotional networks and motor control: a fearful view. , 1996, Progress in brain research.