Analysis of semen parameters in a young cohort of cancer patients

Infertility can be the result of some common cancer treatments and can significantly impact quality of life. Semen cryopreservation allows for fertility preservation. We analyzed the semen parameters of specimens collected from pubertal males from the Children's Hospital of Philadelphia (CHOP) in order to expand current knowledge on the quality of these specimens and inform a standard clinical practice.

[1]  W. Wallace,et al.  Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults. , 2015, The lancet. Diabetes & endocrinology.

[2]  T. Fréour,et al.  Sperm cryopreservation in adolescents and young adults with cancer: results of the French national sperm banking network (CECOS). , 2015, Fertility and sterility.

[3]  C. Haines,et al.  Sperm cryopreservation for Chinese male cancer patients: a 17-year retrospective analysis in an assisted reproductive unit in Hong Kong. , 2013, Hong Kong medical journal = Xianggang yi xue za zhi.

[4]  G. Makin,et al.  Sperm banking in the United Kingdom is feasible in patients 13 years old or older with cancer. , 2012, The Journal of urology.

[5]  L. Cohen,et al.  Barriers to fertility preservation in male adolescents with cancer: it's time for a multidisciplinary approach that includes urologists. , 2012, Urology.

[6]  Z. Rosenwaks,et al.  Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  N. Jørgensen,et al.  Clinical and biochemical correlates of successful semen collection for cryopreservation from 12-18-year-old patients: a single-center study of 86 adolescents. , 2010, Human reproduction.

[8]  J. Romijn,et al.  Gonadal dysfunction in male cancer patients before cytotoxic treatment. , 2010, International journal of andrology.

[9]  Elizabeth Noonan,et al.  World Health Organization reference values for human semen characteristics. , 2010, Human reproduction update.

[10]  M. V. D. van den Heuvel-Eibrink,et al.  Semen cryopreservation in pubertal boys before gonadotoxic treatment and the role of endocrinologic evaluation in predicting sperm yield. , 2008, Fertility and sterility.

[11]  W. Hobbie,et al.  Sperm Banking for Adolescents With Cancer , 2008, Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses.

[12]  Huaqing Zhao,et al.  Sperm Banking for Adolescent and Young Adult Cancer Patients: Sperm Quality, Patient, and Parent Perspectives , 2008, Pediatric blood & cancer.

[13]  M. Hudson,et al.  Concerns about infertility risks among pediatric oncology patients and their parents , 2008, Pediatric blood & cancer.

[14]  G. Makin,et al.  Sperm banking in adolescent cancer patients , 2005, Archives of Disease in Childhood.

[15]  L. Zeltzer,et al.  Fertility issues for young adult survivors of childhood cancer , 2004, Psycho-oncology.

[16]  L. Schover,et al.  Oncologists' attitudes and practices regarding banking sperm before cancer treatment. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  K. Schmiegelow,et al.  Cryopreservation of semen from pubertal boys with cancer. , 2000, Medical and pediatric oncology.

[18]  C. Sklar Reproductive physiology and treatment-related loss of sex hormone production. , 1999, Medical and pediatric oncology.

[19]  S. Shalet,et al.  Gonadal damage from chemotherapy and radiotherapy. , 1998, Endocrinology and metabolism clinics of North America.

[20]  R. Siegberg,et al.  Pregnancy resulting from intracytoplasmic injection of spermatozoa from a frozen-thawed testicular biopsy specimen. , 1996, Human reproduction.

[21]  S. Shalet,et al.  Gonadal function following chemotherapy for childhood Hodgkin's disease. , 1996, Medical and pediatric oncology.

[22]  E. Nieschlag,et al.  Cryopreservation of semen from adolescent patients with malignancies. , 1996, Medical and pediatric oncology.

[23]  L. Robison,et al.  Effects of radiation on testicular function in long-term survivors of childhood acute lymphoblastic leukemia: a report from the Children Cancer Study Group. , 1990, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[24]  Rahul Gupta,et al.  Testicular dysfunction after cyclophosphamide‐vincristine‐procarbazine‐prednisolone chemotherapy for advanced hodgkin's disease a long‐term follow‐up study , 1990 .

[25]  P. Mandrekar,et al.  Testicular dysfunction after cyclophosphamide-vincristine-procarbazine-prednisolone chemotherapy for advanced Hodgkin's disease. A long-term follow-up study. , 1990, Cancer.

[26]  M J Rowley,et al.  Effect of graded doses of ionizing radiation on the human testis. , 1974, Radiation research.