CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation

[1]  B. Göttgens,et al.  JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. , 2021, Blood advances.

[2]  R. Milo,et al.  The distribution of cellular turnover in the human body , 2021, Nature Medicine.

[3]  N. Copeland,et al.  Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence , 2020, Proceedings of the National Academy of Sciences.

[4]  Sofia M. Calado,et al.  CITED2 and the modulation of the hypoxic response in cancer , 2020, World journal of clinical oncology.

[5]  A. Tardivel,et al.  Higher Vertebrate Specific Gene Ribonuclease Inhibitor (RNH1) Is Essential for Adult Hematopoietic Stem Cell Function and Cell Cycle Regulation , 2019, Blood.

[6]  S. Edkins,et al.  Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia , 2019, Stem cell reports.

[7]  H. Sun,et al.  CITED2 mediates the mechanical loading–induced suppression of adipokines in the infrapatellar fat pad , 2019, Annals of the New York Academy of Sciences.

[8]  E. Tran,et al.  Wild-type Kras expands and exhausts hematopoietic stem cells. , 2018, JCI insight.

[9]  Samuel L. Wolock,et al.  A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice. , 2018, Blood.

[10]  S. Rajagopalan,et al.  CITED2 Restrains Proinflammatory Macrophage Activation and Response , 2017, Molecular and Cellular Biology.

[11]  E. Pietras.  Inflammation: a key regulator of hematopoietic stem cell fate in health and disease. , 2017, Blood.

[12]  G. Wertheim,et al.  Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression , 2017, The Journal of experimental medicine.

[13]  D. O’Carroll,et al.  Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions , 2017, The Journal of experimental medicine.

[14]  Nicola K. Wilson,et al.  A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation. , 2016, Blood.

[15]  S. McKinney-Freeman,et al.  Functional screen identifies regulators of murine hematopoietic stem cell repopulation , 2016, The Journal of experimental medicine.

[16]  I. Weissman,et al.  Normal and Neoplastic Stem Cells , 2017, Cold Spring Harbor symposia on quantitative biology.

[17]  Steven L Salzberg,et al.  HISAT: a fast spliced aligner with low memory requirements , 2015, Nature Methods.

[18]  J. Nichols,et al.  Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells , 2014, Stem cells.

[19]  E. Vellenga,et al.  CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia , 2014, Leukemia.

[20]  William J. Israelsen,et al.  Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis , 2014, Cell.

[21]  Sergei A. Vinogradov,et al.  Direct measurement of local oxygen concentration in the bone marrow of live animals , 2014, Nature.

[22]  S. Dunwoodie,et al.  Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells. , 2014, Stem cells and development.

[23]  H. Geiger,et al.  The ageing haematopoietic stem cell compartment , 2013, Nature Reviews Immunology.

[24]  Xin-Yuan Fu,et al.  Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. , 2012, Blood.

[25]  Nathan C Boles,et al.  Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. , 2012, Cell stem cell.

[26]  Jeffrey A. Magee,et al.  Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. , 2012, Cell stem cell.

[27]  S. Chiou,et al.  CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence , 2012, Cell Death and Differentiation.

[28]  S. Dunwoodie,et al.  Cited2 Gene Controls Pluripotency and Cardiomyocyte Differentiation of Murine Embryonic Stem Cells through Oct4 Gene* , 2012, The Journal of Biological Chemistry.

[29]  S. Dunwoodie,et al.  HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. , 2012, Blood.

[30]  A. Barabasi,et al.  Interactome Networks and Human Disease , 2011, Cell.

[31]  S. Morrison,et al.  mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. , 2010, Cell stem cell.

[32]  C. Scott,et al.  Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance. , 2010, Blood.

[33]  B. Leber,et al.  The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity. , 2010, Blood.

[34]  M. Birnbaum,et al.  AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. , 2010, Blood.

[35]  Tariq Enver,et al.  Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells , 2009, Cell stem cell.

[36]  H. Sun,et al.  Identification of CITED2 as a negative regulator of fracture healing. , 2009, Biochemical and biophysical research communications.

[37]  W. Pear,et al.  Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. , 2009, Blood.

[38]  Elinore M Mercer,et al.  E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors , 2009, Proceedings of the National Academy of Sciences.

[39]  Y. Liu,et al.  p53 regulates hematopoietic stem cell quiescence. , 2009, Cell stem cell.

[40]  S. Bamforth,et al.  Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency , 2008, Cardiovascular research.

[41]  S. Ogawa,et al.  This information is current as Hematopoiesis Hematopoietic Stem Cells in Adult AML 1 / Runx 1 Negatively Regulates Quiescent , 2008 .

[42]  Yu-Chung Yang,et al.  Cited2 is required for normal hematopoiesis in the murine fetal liver. , 2007, Blood.

[43]  David M Sabatini,et al.  Defining the role of mTOR in cancer. , 2007, Cancer cell.

[44]  Leonid A. Mirny,et al.  Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells , 2007, Cell.

[45]  Yu-Chung Yang,et al.  Post-transcriptional Control of Cited2 by Transforming Growth Factor β , 2006, Journal of Biological Chemistry.

[46]  S. Dunwoodie,et al.  Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. , 2006, Developmental biology.

[47]  S. Morrison,et al.  Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells , 2006, Nature.

[48]  Xi C. He,et al.  PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention , 2006, Nature.

[49]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[50]  S. Dunwoodie,et al.  Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development , 2005, Development.

[51]  S. Korsmeyer,et al.  Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells , 2005, Science.

[52]  Mark J. Murphy,et al.  c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. , 2004, Genes & development.

[53]  Robert H. Anderson,et al.  Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway , 2004, Nature Genetics.

[54]  J. W. Davis,et al.  Identification of the CREB-binding Protein/p300-interacting Protein CITED2 as a Peroxisome Proliferator-activated Receptor α Coregulator* , 2004, Journal of Biological Chemistry.

[55]  S. Bamforth,et al.  Transcriptional Coactivator Cited2 Induces Bmi1 and Mel18 and Controls Fibroblast Proliferation via Ink4a/ARF , 2003, Molecular and Cellular Biology.

[56]  Mark Coles,et al.  Transgenic mice with hematopoietic and lymphoid specific expression of Cre , 2003, European journal of immunology.

[57]  John T. Dimos,et al.  A Stem Cell Molecular Signature , 2002, Science.

[58]  K. Herrup,et al.  The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Jennifer N. Murdoch,et al.  Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator , 2001, Nature Genetics.

[60]  S. Bhattacharya,et al.  Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. , 1999, Genes & development.