Involvement of the N-methyl- d -aspartate receptors of the vestibular nucleus in the gaze-holding system of the cat

Eye movements were recorded in alert cats after injections into one of the medial vestibular nuclei (MVN) either of a N-methyl-D-aspartate (NMDA) antagonist or of a non-NMDA antagonist. A gaze-holding failure was caused by the NMDA antagonist when it was injected into the central part of the MVN but not when it was injected into the rostral part of that nucleus. By contrast, injections of the non-NMDA-receptor antagonist into the MVN did not cause any sign of gaze-holding failure. We conclude that the NMDA receptors located in the central part of the MVN are involved in the gaze-holding system.

[1]  G. Cheron,et al.  Lesions in the cat prepositus complex: effects on the vestibulo‐ocular reflex and saccades. , 1986, The Journal of physiology.

[2]  E. Gellhorn.  Effect of afferent impulses on cortical suppressor areas. , 1947, Journal of neurophysiology.

[3]  G. Cheron,et al.  Differential effect of injections of kainic acid into the prepositus and the vestibular nuclei of the cat. , 1993, The Journal of physiology.

[4]  G. Cheron,et al.  Disabling of the oculomotor neural integrator by kainic acid injections in the prepositus‐vestibular complex of the cat. , 1987, The Journal of physiology.

[5]  A. Fuchs,et al.  Discharge patterns in nucleus prepositus hypoglossi and adjacent medial vestibular nucleus during horizontal eye movement in behaving macaques. , 1992, Journal of neurophysiology.

[6]  B. Cohen,et al.  Unit activity in the pontine reticular formation associated with eye movements , 1972 .

[7]  L. Nowak,et al.  Quisqualate‐ and kainate‐activated channels in mouse central neurones in culture. , 1988, The Journal of physiology.

[8]  D. Robinson.  Eye Movement Control in Primates , 1968 .

[9]  E. Nielsen,et al.  2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. , 1990, Science.

[10]  G. Cheron,et al.  Effect of muscimol microinjections into the prepositus hypoglossi and the medial vestibular nuclei on cat eye movements. , 1994, Journal of neurophysiology.

[11]  L. Ziskind-Conhaim,et al.  NMDA receptors mediate poly- and monosynaptic potentials in motoneurons of rat embryos , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  D. Robinson.  Oculomotor unit behavior in the monkey. , 1970, Journal of neurophysiology.

[13]  J. Watkins,et al.  2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation , 1981, Neuroscience Letters.

[14]  S. Grillner,et al.  Dual-component synaptic potentials in the lamprey mediated by excitatory amino acid receptors , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.