Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

[1]  Yosuke Tamada,et al.  DNA damage triggers reprogramming of differentiated cells into stem cells in Physcomitrella , 2020, Nature Plants.

[2]  Nick C Fox,et al.  Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolution , 2020, bioRxiv.

[3]  Gunnar H. D. Poplawski,et al.  Injured adult neurons regress to an embryonic transcriptional growth state , 2020, Nature.

[4]  G. Schroth,et al.  Dedifferentiation and neuronal repression define familial Alzheimer’s disease , 2019, Science Advances.

[5]  D. Geschwind,et al.  Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury , 2019, Neuron.

[6]  J. Mertens,et al.  Next‐generation disease modeling with direct conversion: a new path to old neurons , 2019, FEBS letters.

[7]  Raphaella W. L. So,et al.  Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence , 2019, Nature Neuroscience.

[8]  John F. Ouyang,et al.  A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation , 2019, Nature Neuroscience.

[9]  P. Greengard,et al.  Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. , 2019, Cell stem cell.

[10]  O. Brüstle Faculty Opinions recommendation of Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[11]  S. Horvath,et al.  Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation , 2019, Aging.

[12]  Manolis Kellis,et al.  Single-cell transcriptomic analysis of Alzheimer’s disease , 2019, Nature.

[13]  J. Garrido,et al.  Primary neurons can enter M-phase , 2019, Scientific Reports.

[14]  L. Goldstein,et al.  Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons , 2019, Cell stem cell.

[15]  Baptiste N. Jaeger,et al.  Pathological priming causes developmental gene network heterochronicity in autism patient-derived neurons , 2019, Nature Neuroscience.

[16]  G. Church,et al.  REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease , 2019, Cell reports.

[17]  Daniela Matei,et al.  Targeting Cancer Stemness in the Clinic: From Hype to Hope. , 2019, Cell stem cell.

[18]  Douglas Galasko,et al.  Alzheimer's disease: The right drug, the right time , 2018, Science.

[19]  F. Gage,et al.  Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. , 2018, Annual review of genetics.

[20]  Howard Y. Chang,et al.  Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons , 2018, bioRxiv.

[21]  Alex P. Reiner,et al.  Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies , 2018, Aging.

[22]  Stephan J Sanders,et al.  Progress in Understanding and Treating SCN2A-Mediated Disorders , 2018, Trends in Neurosciences.

[23]  Joseph R. Scarpa,et al.  Epigenetic regulation of brain region-specific microglia clearance activity , 2018, Nature Neuroscience.

[24]  Baptiste N. Jaeger,et al.  Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. , 2018, Cell reports.

[25]  Zhandong Liu,et al.  Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila , 2018, eLife.

[26]  Jianxin Shi,et al.  Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model , 2018, Stem cell research.

[27]  G. Pesole,et al.  Whole transcriptome profiling of Late-Onset Alzheimer’s Disease patients provides insights into the molecular changes involved in the disease , 2018, Scientific Reports.

[28]  J. Mertens,et al.  Human neurons to model aging: A dish best served old. , 2018, Drug discovery today. Disease models.

[29]  Chun-li Zhang,et al.  Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons , 2017, Front. Mol. Neurosci..

[30]  K. Poss,et al.  Cardiac regeneration strategies: Staying young at heart , 2017, Science.

[31]  Michael P. Snyder,et al.  Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression , 2017, Nature Communications.

[32]  S. Bottani,et al.  Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance. , 2017, Trends in cell biology.

[33]  Werner L. Straube,et al.  Serum Proteases Potentiate BMP-Induced Cell Cycle Re-entry of Dedifferentiating Muscle Cells during Newt Limb Regeneration. , 2017, Developmental cell.

[34]  Joseph R Ecker,et al.  Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain. , 2016, Cell reports.

[35]  C. R. Esteban,et al.  In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming , 2016, Cell.

[36]  E. Topol,et al.  Influence of donor age on induced pluripotent stem cells , 2016, Nature Biotechnology.

[37]  James A. Eddy,et al.  Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases , 2016, Scientific Data.

[38]  Matheus B. Victor,et al.  Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts , 2016, eLife.

[39]  Avi Ma'ayan,et al.  Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration , 2016, Nature Neuroscience.

[40]  K. Blennow,et al.  Alzheimer's disease , 2016, The Lancet.

[41]  F. Gage,et al.  Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation , 2016, eLife.

[42]  Xinjian Wang,et al.  Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs. , 2016, Cell stem cell.

[43]  G. Perry,et al.  Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities , 2016, Oncotarget.

[44]  Shijie C. Zheng,et al.  Epigenetic drift, epigenetic clocks and cancer risk. , 2016, Epigenomics.

[45]  B. Stanger,et al.  Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style , 2016, Nature Reviews Molecular Cell Biology.

[46]  Adila Elobeid,et al.  Altered Proteins in the Aging Brain , 2016, Journal of neuropathology and experimental neurology.

[47]  Eric Karran,et al.  The Cellular Phase of Alzheimer’s Disease , 2016, Cell.

[48]  Jürgen Winkler,et al.  Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. , 2015, Cell stem cell.

[49]  Ari S. Morcos,et al.  REST Regulates Non–Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II , 2015, The Journal of Neuroscience.

[50]  J. Nurnberger,et al.  Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder , 2015, Nature.

[51]  Steven D. Edland,et al.  Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. , 2015, Cell stem cell.

[52]  Alzheimer’s Association 2015 Alzheimer's disease facts and figures , 2015, Alzheimer's & Dementia.

[53]  Mandana Arbab,et al.  Modeling motor neuron disease: the matter of time , 2014, Trends in Neurosciences.

[54]  Matheus B. Victor,et al.  Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts , 2014, Neuron.

[55]  Yuan Tian,et al.  A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells , 2014, Neuron.

[56]  H. Zetterberg,et al.  Understanding the cause of sporadic Alzheimer’s disease , 2014, Expert review of neurotherapeutics.

[57]  David A. Bennett,et al.  REST and Stress Resistance in Aging and Alzheimer’s Disease , 2014, Nature.

[58]  Doheon Lee,et al.  Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage. , 2014, Human molecular genetics.

[59]  D. Krainc,et al.  Human iPSC-based modeling of late-onset disease via progerin-induced aging. , 2013, Cell stem cell.

[60]  J. Mertens,et al.  APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation , 2013, Stem cell reports.

[61]  Kun Zhang,et al.  The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. , 2013, Cell reports.

[62]  S. Horvath DNA methylation age of human tissues and cell types , 2013, Genome Biology.

[63]  Howard Y. Chang,et al.  Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position , 2013, Nature Methods.

[64]  Andrew E. Teschendorff,et al.  Age-associated epigenetic drift: implications, and a case of epigenetic thrift? , 2013, Human molecular genetics.

[65]  Joshua C. Chang,et al.  Small Molecules Enable Neurogenin 2 to Efficiently Convert Human Fibroblasts to Cholinergic Neurons , 2013, Nature Communications.

[66]  M. Deshmukh,et al.  Mature neurons: equipped for survival , 2013, Cell Death and Disease.

[67]  J. Mertens,et al.  Embryonic stem cell-based modeling of tau pathology in human neurons. , 2013, The American journal of pathology.

[68]  J. D. Mills,et al.  RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism , 2013, Neuroscience Letters.

[69]  J. Satoh,et al.  ChIP-Seq Data Mining: Remarkable Differences in NRSF/REST Target Genes between Human ESC and ESC-Derived Neurons , 2013, Bioinformatics and biology insights.

[70]  J. Mertens,et al.  Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation. , 2012, The American journal of pathology.

[71]  T. Arendt Cell Cycle Activation and Aneuploid Neurons in Alzheimer's Disease , 2012, Molecular Neurobiology.

[72]  Peter Wernet,et al.  Small molecules enable highly efficient neuronal conversion of human fibroblasts , 2012, Nature Methods.

[73]  Kristopher L. Nazor,et al.  Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells , 2012, Nature.

[74]  S. Bicciato,et al.  The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells , 2011, Cell.

[75]  Eric M. Blalock,et al.  Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease , 2011, Journal of Chemical Neuroanatomy.

[76]  W. Lowry,et al.  Defining the nature of human pluripotent stem cell progeny , 2011, Cell Research.

[77]  Thomas Vierbuchen,et al.  Induction of human neuronal cells by defined transcription factors , 2011, Nature.

[78]  Jürgen Götz,et al.  Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease , 2011, Nature Reviews Neuroscience.

[79]  R. Taschereau,et al.  Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures , 2010, Nucleic acids research.

[80]  J. C. Belmonte,et al.  Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation , 2010, Nature.

[81]  Sun-Chong Wang,et al.  Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease , 2008, PloS one.

[82]  T. Hortobágyi,et al.  THE NEURONAL CELL CYCLE AS A MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE , 2008 .

[83]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[84]  T. Arendt,et al.  Aneuploidy and DNA Replication in the Normal Human Brain and Alzheimer's Disease , 2007, The Journal of Neuroscience.

[85]  Karl Herrup,et al.  Cell cycle regulation in the postmitotic neuron: oxymoron or new biology? , 2007, Nature Reviews Neuroscience.

[86]  M. Wolfe When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40 , 2007 .

[87]  M. Mattson,et al.  Ageing and neuronal vulnerability , 2006, Nature Reviews Neuroscience.

[88]  Jeffrey T. Chang,et al.  Oncogenic pathway signatures in human cancers as a guide to targeted therapies , 2006, Nature.

[89]  M. Coleman Axon degeneration mechanisms: commonality amid diversity , 2005, Nature Reviews Neuroscience.

[90]  Don L. Armstrong,et al.  Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease , 2005, Nature Medicine.

[91]  A. Andreadis Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. , 2005, Biochimica et biophysica acta.

[92]  C. Woolf,et al.  Adult neuron survival strategies — slamming on the brakes , 2004, Nature Reviews Neuroscience.

[93]  Roland N. Emokpae,et al.  Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage , 2004, Neuron.

[94]  T. Foster,et al.  Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment , 2003, The Journal of Neuroscience.

[95]  B. Ghetti,et al.  Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[96]  K. Herrup,et al.  DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease , 2001, The Journal of Neuroscience.

[97]  T. Arendt,et al.  Activated Mitogenic Signaling Induces a Process of Dedifferentiation in Alzheimer's Disease That Eventually Results in Cell Death , 2000, Annals of the New York Academy of Sciences.

[98]  J. Nevins,et al.  Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. , 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[99]  M. Smith,et al.  Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease. , 1999, Medical hypotheses.

[100]  K. Herrup,et al.  Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain , 1998, The Journal of Neuroscience.

[101]  A. Smith,et al.  Cell cycle markers in the hippocampus in Alzheimer’s disease , 1997, Acta Neuropathologica.

[102]  N. Jha,et al.  Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die? , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[103]  F. Gage,et al.  Generation of functional human serotonergic neurons from fibroblasts , 2016, Molecular Psychiatry.

[104]  F. LaFerla,et al.  Alzheimer's disease. , 2010, The New England journal of medicine.

[105]  Malay Mandal,et al.  Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia , 2007, Nature Medicine.

[106]  B. Hyman,et al.  Edinburgh Research Explorer Alzheimer's disease , 2022 .