Dipalmitoylphosphatidylcholine (L‐α‐lecithin) stimulates prostaglandin E production in human amnion

Summary. The effect of dipalmitoylphosphatidylcholine (DPPC, L‐αlecithin), a substance not containing arachidonic acid, on prostaglandin E (PGE) production of amniotic membrane was studied. DPPC (3.125800 μg/ml) stimulated PGE production of amniotic membrane (150200%), suggesting that lecithin, the major surfactant component, is directly involved in the mechanism of human parturition as a stimulator of PGE production.

[1]  P. Donnai,et al.  Human amniotic fluid urogastrone (epidermal growth factor) and fetal lung phospholipids , 1989, British journal of obstetrics and gynaecology.

[2]  A. Turnbull,et al.  Surfactant stimulates prostaglandin E production in human amnion , 1988, British journal of obstetrics and gynaecology.

[3]  M. Mitchell.  Actions of transforming growth factors on amnion cell prostaglandin biosynthesis. , 1988, Prostaglandins, leukotrienes, and essential fatty acids.

[4]  M. Casey,et al.  Epidermal growth factor stimulation of prostaglandin E2 biosynthesis in amnion cells. Induction of prostaglandin H2 synthase. , 1988, The Journal of biological chemistry.

[5]  J. Hobbins,et al.  Endotoxin Stimulates Prostaglandin E2 Production by Human Amnion , 1988, Obstetrics and gynecology.

[6]  A. Turnbull,et al.  Effect of relaxin on prostaglandin E production by human amnion: changes in relation to the onset of labour , 1987, British journal of obstetrics and gynaecology.

[7]  M. Mitchell,et al.  Epidermal growth factor-stimulated prostaglandin E2 production in human amnion cells: specificity and nonesterified arachidonic acid dependency , 1987, Molecular and Cellular Endocrinology.

[8]  D. Hoffman,et al.  Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. , 1985, Prostaglandins.

[9]  S. Skinner,et al.  Partial purification and characterisation of two compounds from amniotic fluid which inhibit phospholipase activity in human endometrial cells. , 1985, Biochemical and biophysical research communications.

[10]  N. Dubin,et al.  Inhibition of fetal membrane prostaglandin production by prolactin: relative importance in the initiation of labor. , 1985, American journal of obstetrics and gynecology.

[11]  G. Liggins,et al.  Inhibitory effects of dispersed human amnion cells on production rates of prostaglandin E and F by endometrial cells. , 1984, Prostaglandins.

[12]  A. Fuchs,et al.  Stimulation of myometrial and decidual prostaglandin production by amniotic fluid from term, but not midtrimester pregnancies. , 1983, Prostaglandins.

[13]  J. Challis,et al.  Prostaglandin synthesis by human amnion is dependent upon extracellular calcium. , 1983, Canadian journal of physiology and pharmacology.

[14]  J. Challis,et al.  Estradiol-17β and 2-hydroxyestradiol-17β-induced differential production of prostaglandins by cells dispersed from human intrauterine tissues at parturition , 1983 .

[15]  J. Okita,et al.  Initiation of human parturition. , 1982, American journal of obstetrics and gynecology.

[16]  J. Okita,et al.  Initiation of human parturition. XII. Biosynthesis and metabolism of prostaglandins in human fetal membranes and uterine decidua. , 1981, American journal of obstetrics and gynecology.

[17]  M. Oulton.  The role of centrifugation in the measurement of surfactant in amniotic fluid. , 1979, American journal of obstetrics and gynecology.

[18]  L. Gluck,et al.  Lecithin-sphingomyelin ratios in amniotic fluid in normal and abnormal pregnancy. , 1973, American journal of obstetrics and gynecology.

[19]  M D Mitchell,et al.  Interleukin-1 stimulates prostaglandin biosynthesis by human amnion. , 1989, Prostaglandins.

[20]  M. Mitchell,et al.  Stimulation of prostaglandin E production in superfused human amnion by human amniotic fluid. , 1987, Gynecologic and obstetric investigation.

[21]  M. Yamaguchi,et al.  6-Keto prostaglandin F1 alpha, thromboxane B2, and 13,14-dihydro-15-keto prostaglandin F concentrations of normotensive and preeclamptic patients during pregnancy, delivery, and the postpartum period. , 1985, American journal of obstetrics and gynecology.

[22]  M. Anceschi,et al.  Beta-adrenergic stimulation of prostaglandin production by human amnion tissue. , 1984, Prostaglandins.

[23]  P. Husslein,et al.  Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin. , 1981, American journal of obstetrics and gynecology.