The pheromone response pathway in Saccharomyces cerevisiae.

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 OVERVIEW OF PATHWAY . . . . . . . . . . .. . . . . . . .. . . . . . . . . . . . . . . 149 Pheromones . . . . . . ... ... . .. . . .... . . . . ..... . . . . . .. . . . . . . 149 Pheromone Receptors . . . .... . . . . . . .. . . . . . . . . . . . . . . . . ISO G Protein. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 5 1 Kinases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 SteJ2p Transcription Factor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 154 Inhibition of Gl CyclinlCdc28 Kinase Leads to Cell Cycle Arrest . . . . . . . . . 154 Recovery and Desensitizatiofl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ISS IDENTIRCATION OF EFFECTOR CANDIDATES . . . . . . . . . . . . . . . . . . . . ISS MAP KINASE CASCADE . . . .. . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . 159 Action and Order of Kinases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 59 Heterologous MAP Kinase Cascades . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 . FUflctional Conservation of MAP Kinase Cascade Componeflls . . . . . . . . . . . 167 Other MAP Kinase Cascades in S. cerevisiae . . . . . . . . . . . .. . . . . . . . . . 168 CELL CYCLE ARREST . . . .. . . . . .. . ... .. ... . . . .. ... . .. . .. . .. 170 DOES CALCINEURIN PLAY A ROLE IN RECOVERY? . . . . . . . . . . . . . . . . 1 7 1 PROSPECTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173

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