Maspin as a tumour suppressor in salivary gland tumour.

Maspin is a protein that belongs to serin protease inhibitor (serpin) superfamily. The purpose of this study was to review the literature concerning the expression of maspin in salivary gland tumours. A literature search was done using MEDLINE, accessed via the National Library of Medicine PubMed interface. Statistical analysis was not done because only seven studies were available in literature, the collected data were different and the results could not be compared. Expression of maspin was down regulated in more aggressive salivary gland tumours. Maspin may function as a tumour suppressor in salivary gland tumours.

[1]  M. Hendrix,et al.  Editor's Note: The Paradoxical Expression of Maspin in Ovarian Carcinoma , 2002, Clinical Cancer Research.

[2]  Silvia Pagliaretta,et al.  Role of maspin in cancer , 2013, Clinical and Translational Medicine.

[3]  T. Ettl,et al.  Salivary gland carcinomas , 2012, Oral and Maxillofacial Surgery.

[4]  S. Ghazy,et al.  Maspin and MCM2 immunoprofiling in salivary gland carcinomas , 2011, Diagnostic pathology.

[5]  Xiu-sheng He,et al.  Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis , 2011, Journal of experimental & clinical cancer research : CR.

[6]  Xiaojie Zhu,et al.  Myoepithelial carcinoma of intraoral minor salivary glands: a clinicopathological study of 7 cases and review of the literature. , 2010, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[7]  H. Ozguc,et al.  Maspin expression in gastrointestinal stromal tumors , 2010, World journal of surgical oncology.

[8]  I. Allon,et al.  Is maspin immunolocalization a tool to differentiate central low-grade mucoepidermoid carcinoma from glandular odontogenic cyst? , 2010, Acta histochemica.

[9]  T. Ettl,et al.  Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors. , 2008, Oral oncology.

[10]  Catalin C. Barbacioru,et al.  Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma , 2008, Modern Pathology.

[11]  J. Tong,et al.  The expression of Maspin in mucoepidermoid carcinoma of salivary gland and its clinical significance , 2008 .

[12]  J. Chan,et al.  Advances in salivary gland pathology , 2007, Histopathology.

[13]  A. Altemani,et al.  Maspin expression in carcinoma ex pleomorphic adenoma , 2005, Journal of Clinical Pathology.

[14]  L. Barnes,et al.  Pathology and genetics of head and neck tumours , 2005 .

[15]  M. Martins,et al.  Maspin expression in normal and neoplastic salivary gland. , 2004, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[16]  S. Sheng,et al.  Maspin sensitizes breast carcinoma cells to induced apoptosis , 2002, Oncogene.

[17]  O. Blacque,et al.  Evidence for a Direct Interaction between the Tumor Suppressor Serpin, Maspin, and Types I and III Collagen* , 2002, The Journal of Biological Chemistry.

[18]  J. Whisstock,et al.  The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins , 2001, The Journal of Biological Chemistry.

[19]  D. Johnston,et al.  High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma , 2000, Oncogene.

[20]  O. Volpert,et al.  Maspin is an angiogenesis inhibitor , 2000, Nature Medicine.

[21]  M. Hendrix,et al.  Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Hendrix,et al.  Maspin: a tumor suppressing serpin. , 1996, Current topics in microbiology and immunology.

[23]  J. Potempa,et al.  The serpin superfamily of proteinase inhibitors: structure, function, and regulation. , 1994, The Journal of biological chemistry.

[24]  M. Hendrix,et al.  Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. , 1994, Science.