Formulation and in vitro evaluation of cefpodoxime proxetil gastro retentive microspheres

The objective of the present study was to develop floating microspheres of Cefpodoxime Proxetil (CP) in order to achieve an extended retention in the upper GIT, to protect the prodrug from enzymatic attack which may enhance the absorption and improve the bioavailability. The microspheres were prepared by solvent diffusion method using different ratios of Cefpodoxime proxetil, hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose. The floating microspheres showed better result and it may be use full for prolong the drug release in stomach and improve the bioavailability. Floating microspheres of cefpodoxime proxetil at the higher polymer to drug ratio improved the entrapment efficiency, percentage of yield as well as buoyancy percentage. In case of lower polymer to drug ratio there was a significant increase in drug release. The important factors of floating microspheres is drug release & entrapment efficiency. In-vitro release of formulation F7 in pH 1.2 HCl buffer and in simulated gastric fluid (SGF) were 67.52% and 68.32% respectively which showed sustained release over a period of 12 hrs and the drug entrapment efficiency 79.42%.

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