Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy

Patients with non-alcoholic fatty liver disease (NAFLD) have impaired health-related quality of life including physical and mental state. Near-infrared spectroscopy (NIRS) is a useful tool for evaluation of brain activity and depressive state. This study aimed to determine the brain activity of female NAFLD patients using NIRS. Cerebral oxygenated hemoglobin (oxy-Hb) concentration during a verbal fluency task (VFT) was measured using NIRS in 24 female NAFLD patients and 15 female healthy controls. The Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire was administered to both groups before NIRS. There was no significant difference in CES-D score between groups. However, the oxy-Hb concentration and number of words during the VFT were less in NAFLD compared to healthy controls. The mean value of oxy-Hb concentration during 0–60 s VFT in the frontal lobe was also smaller in NAFLD patients compared to healthy controls (0.082 ± 0.126 vs. 0.183 ± 0.145, P < 0.001). Cerebral oxygen concentration is poorly reactive in response to VFT in female NAFLD patients. This may indicate an association between decreased brain activity and NAFLD regardless of depression.

[1]  K. Abe,et al.  Reduced frontal activation during verbal fluency task in chronic hepatitis C patients with interferon‐based therapy as measured by near‐infrared spectroscopy , 2017, Hepatology research : the official journal of the Japan Society of Hepatology.

[2]  Jeanne M. Clark,et al.  Nonalcoholic fatty liver disease is associated with cognitive function in adults , 2016, Neurology.

[3]  J. Talwalkar,et al.  Reliability and validity of the Chronic Liver Disease Questionnaire (CLDQ) in adults with non-alcoholic steatohepatitis (NASH) , 2016, BMJ open gastroenterology.

[4]  K. Abe,et al.  The Association between Sleep Duration and Non-Alcoholic Fatty Liver Disease among Japanese Men and Women , 2015, Obesity Facts.

[5]  Y. Hirayasu,et al.  Non‐alcoholic fatty liver disease comorbid with major depressive disorder: The pathological features and poor therapeutic efficacy , 2015, Journal of gastroenterology and hepatology.

[6]  W. Nseir,et al.  Role of diet and lifestyle changes in nonalcoholic fatty liver disease. , 2014, World journal of gastroenterology.

[7]  Masato Fukuda,et al.  Neuroimaging-aided differential diagnosis of the depressive state , 2014, NeuroImage.

[8]  Yoosoo Chang,et al.  Sleep duration and quality in relation to non-alcoholic fatty liver disease in middle-aged workers and their spouses. , 2013, Journal of hepatology.

[9]  A. Suzuki,et al.  Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease , 2013, Liver international : official journal of the International Association for the Study of the Liver.

[10]  P. Drummond,et al.  A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. , 2013, Journal of affective disorders.

[11]  Heidrun Wabnitz,et al.  The physiological origin of task-evoked systemic artefacts in functional near infrared spectroscopy , 2012, NeuroImage.

[12]  Reiko Kawagoe,et al.  Influence of skin blood flow on near-infrared spectroscopy signals measured on the forehead during a verbal fluency task , 2011, NeuroImage.

[13]  M. Kurosaki,et al.  Impaired Brain Activity in Cirrhotic Patients With Minimal Hepatic Encephalopathy: Evaluation by Near Infrared Spectroscopy , 2011 .

[14]  M. Stepanova,et al.  Depression in patients with nonalcoholic fatty liver disease and chronic viral hepatitis B and C. , 2011, Psychosomatics.

[15]  Heide Klumpp,et al.  Review of brain functioning in depression for semantic processing and verbal fluency. , 2010, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[16]  Akiko Noda,et al.  Insufficient sleep impairs driving performance and cognitive function , 2010, Neuroscience Letters.

[17]  K. Kowdley,et al.  Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network , 2009, Hepatology.

[18]  Masato Fukuda,et al.  Reduced frontopolar activation during verbal fluency task in schizophrenia: A multi-channel near-infrared spectroscopy study , 2008, Schizophrenia Research.

[19]  L. Gerber,et al.  Health‐related quality of life in patients with non‐alcoholic fatty liver disease , 2007, Alimentary pharmacology & therapeutics.

[20]  G. Lau,et al.  Guidelines for the assessment and management of non‐alcoholic fatty liver disease in the Asia–Pacific region: Executive summary , 2007, Journal of gastroenterology and hepatology.

[21]  Yunjie Tong,et al.  Spatially weighted BOLD signal for comparison of functional magnetic resonance imaging and near-infrared imaging of the brain , 2006, NeuroImage.

[22]  R. Clouse,et al.  Depression, Anxiety, and Nonalcoholic Steatohepatitis , 2006, Psychosomatic medicine.

[23]  Clayton E. Curtis,et al.  Maintenance of Spatial and Motor Codes during Oculomotor Delayed Response Tasks , 2004, The Journal of Neuroscience.

[24]  David A. Boas,et al.  A Quantitative Comparison of Simultaneous BOLD fMRI and NIRS Recordings during Functional Brain Activation , 2002, NeuroImage.

[25]  E M Reiman,et al.  Effect of satiation on brain activity in obese and lean women. , 2001, Obesity research.

[26]  A. Villringer,et al.  Cerebral oxygenation changes in response to motor stimulation. , 1996, Journal of applied physiology.

[27]  Daniel J Buysse,et al.  The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research , 1989, Psychiatry Research.

[28]  M. Weissman,et al.  Assessing depressive symptoms in five psychiatric populations: a validation study. , 1977, American journal of epidemiology.

[29]  Z. Younossi,et al.  Association of chronic liver disease with depression: a population-based study. , 2013, Psychosomatics.

[30]  D. Dumitrascu,et al.  Depression and anxiety in nonalcoholic steatohepatitis: is there any association? , 2011, Romanian journal of internal medicine = Revue roumaine de medecine interne.

[31]  須藤 友博.  Multichannel near-infrared spectroscopy in depression and schizophrenia : Cognitive brain activation study , 2004 .

[32]  R. Spitzer,et al.  The PHQ-9: validity of a brief depression severity measure. , 2001, Journal of general internal medicine.