Impaired hippocampal long‐term potentiation in microtubule‐associated protein 1B‐deficient mice

Microtubule‐associated protein (MAP)1B‐heterozygous (MAP1B+/−) mice are deficient in the expression of MAP1B in the hippocampus, cerebellum, and olfactory cortex. Although MAP1B+/− mice showed half the normal levels of MAP1B protein, they had no measurable amounts of phosphorylated MAP1B. High‐frequency θ burst stimulation of Schaffer collateral‐CA1 axons in hippocampal slices from MAP1B+/− mice elicited long‐term potentiation (LTP) that decayed rapidly to baseline, in contrast to the non‐decremental LTP exhibited by age‐matched wild‐type slices. A separate group of MAP1B+/− and wild‐type slices was examined for a longer time course of 3 hr post‐tetanus in response to multiple high‐frequency stimulus trains that induced saturated LTP. MAP1B+/− slices showed marked reductions in both immediate post‐tetanic potentiation and LTP that decayed much more rapidly than that in wild‐type slices. The induction of LTP was associated with a rapid dephosphorylation of MAP1B within 5–15 min post‐tetanus, suggesting that the normal expression of MAP1B and conversion to a dephosphorylated state may be a cellular mediator of cytoskeletal alterations necessary for long‐term activity‐dependent synaptic plasticity. © 2005 Wiley‐Liss, Inc.

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