Changes with age in the peripheral nerves of the rat

SummaryUltrastructural observations have been made on the tibial and plantar nerves of Wistar rats aged 18–24 months. Changes indicative of segmental demyelination and remyelination and axonal degeneration and regeneration were prominent in the plantar nerves. Both in the plantar and tibial nerves, but particularly in the former, axonal abnormalities were frequent. These included the occurrence of multiple intra-axonal vacuoles containing glycogen and polyglucosan bodies. Axonal sequestration by adaxonal Schwann cell processes was also increased. The Schwann cell cytoplasm in relation to this activity contained bundles of filaments with the ultrastructural features of Hirano bodies. The changes in the plantar nerves probably indicate a pressure neuropathy, but the possibility of a superimposed distal axonal degeneration related to aging cannot be excluded on the present evidence. Such changes must be taken into consideration in experimental studies performed on rats of this age.

[1]  H. Ramsey.  ULTRASTRUCTURE OF CORPORA AMYLACEA. , 1965, Journal of neuropathology and experimental neurology.

[2]  P K Thomas,et al.  Age changes in the tibial and plantar nerves of the rat. , 1980, Journal of anatomy.

[3]  R. Gilliatt,et al.  Pressure neuropathy in the hind foot of the guinea-pig , 1967 .

[4]  S. A. Gilmore.  Spinal nerve root degeneration in aging laboratory rats: A light microscopic study , 1972, The Anatomical record.

[5]  E. J. Field,et al.  Electron microscopic observations on the cerebellar cortex in kuru. , 1969, Journal of the neurological sciences.

[6]  L. Kurland,et al.  The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and "rod-like" structures as seen in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex. , 1968, Journal of neuropathology and experimental neurology.

[7]  P. Thomas,et al.  The examination of isolated nerve fibres by light and electron microscopy, with observations on demyelination proximal to neuromas , 2004, Acta Neuropathologica.

[8]  P. Thomas,et al.  Changes due to age in internodal length in the sural nerve in man. , 1966, Journal of neurology, neurosurgery, and psychiatry.

[9]  Y. Yamamura,et al.  Hirano bodies in the axon of peripheral nerves in a case with progressive external ophthalmoplegia with multisystemic involvements , 2004, Acta Neuropathologica.

[10]  J. Ochoa,et al.  The normal sural nerve in man. II. Changes in the axons and Schwann cells due to ageing. , 1969, Acta neuropathologica.

[11]  E. Gardner,et al.  Decrease in number of myelinated fibers in human spinal roots with age , 1937 .

[12]  L. Kurland,et al.  THE FINE STRUCTURE OF SOME INTRAGANGLIONIC ALTERATIONS , 1968 .

[13]  J. Hassoun,et al.  [Infantile neuroaxonal dystrophy or Seitelberger's disease. 3. Ultrastructural study of striated muscle]. , 1971, Acta neuropathologica.

[14]  A. Charters,et al.  Alloxan diabetic neuropathy , 1977, Neurology.

[15]  P. Spencer,et al.  Ultrastructural studies of the dying-back process II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons , 1974, Journal of neurocytology.

[16]  L. Kurland,et al.  Amyotrophic lateral sclerosis and Parkinsonism-dementia complex on Guam. Further pathologic studies. , 1966, Archives of neurology.

[17]  H. M. Dembitzer,et al.  EOSINOPHILIC ROD‐LIKE STRUCTURES IN MYELINATED FIBERS OF HAMSTER SPINAL ROOTS , 1976 .

[18]  A. Weddell,et al.  A quantitative study of peripheral nerve fibres in the mouse following the administration of drugs. 1. Age changes in untreated CBA mice from 3 to 21 months of age. , 1978, Journal of anatomy.

[19]  H. Cravioto,et al.  A study of rod-like structures (Hirano bodies) in 240 normal and pathological brains , 2004, Acta Neuropathologica.

[20]  P S Spencer,et al.  Peripheral Nerve Abnormalities in Aging Rats , 1979, Journal of neuropathology and experimental neurology.

[21]  R. R. Cowden,et al.  Myoclonus epilepsy with Lafora bodies. An ultrastruc- tural and cytochemical study. , 1968, Archives of pathology.

[22]  H. Ward,et al.  GLYCOGEN ACCUMULATION IN THE NERVES AND KIDNEY OF CHRONICALLY DIABETIC RATS: A QUANTITATIVE ELECTRON MICROSCOPIC STUDY , 1979, Journal of neuropathology and experimental neurology.

[23]  S. Carpenter,et al.  The childhood type of dermatomyositis , 1976, Neurology.

[24]  T. Howell.  Senile Deterioration of the Central Nervous System , 1949 .

[25]  I. Duncan,et al.  Age changes in the dorsal and ventral lumbar nerve roots of dogs , 2004, Acta Neuropathologica.

[26]  M. Sakai,et al.  Studies in myoclonus epilepsy (Lafora body form) , 1970, Neurology.

[27]  A. Anzil,et al.  Rod-shaped filamentous inclusions and other ultrastructural features in a cerebellar astrocytoma , 1975, Acta Neuropathologica.

[28]  J. Ochoa,et al.  The normal sural nerve in man , 2004, Acta Neuropathologica.

[29]  J. Jacobs,et al.  Aggregations of filaments in Schwann cells of spinal roots of the normal rat , 1972, Journal of neurocytology.

[30]  B. Berg,et al.  Degenerative lesions of spinal roots and peripheral nerves in aging rats. , 1962, Gerontologia.

[31]  M. Critchley.  THE NEUROLOGY OF OLD AGE. , 1931 .

[32]  L. Cottrell.  HISTOLOGIC VARIATIONS WITH AGE IN APPARENTLY NORMAL PERIPHERAL NERVE TRUNKS , 1940 .

[33]  H. Tohgi,et al.  Quantitative changes with age in normal sural nerves , 1977, Acta Neuropathologica.

[34]  P. Johnson.  ANTERIOR HORN CELL EOSINOPHILIC CYTOPLASMIC INCLUSION BODIES IN SPORATIC MOTOR NEURON DISEASE OF ADULTS: 137 , 1976 .

[35]  M. Tomonaga.  Ultrastructure of Hirano bodies , 2004, Acta Neuropathologica.

[36]  J. Hassoun,et al.  Un cas de dystrophie neuroaxonale infantile ou maladie de Seitelberger , 1971, Acta Neuropathologica.

[37]  A. Asbury,et al.  Pathology of peripheral nerve. , 1978, Major problems in pathology.