Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
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Henrik Antti | Elaine Holmes | John C Lindon | Jeremy K Nicholson | Urs Niederhauser | Michael D Reily | Lois Lehman-McKeeman | Peter Luke | T. Ebbels | H. Senn | M. Reily | J. Lindon | J. Nicholson | H. Keun | E. Holmes | O. Beckonert | J. Colet | M. Bollard | H. Antti | D. Robertson | B. Car | L. Lehman-Mckeeman | A. Tymiak | R. Bible | U. Niederhauser | Mary E Bollard | Hector Keun | Olaf Beckonert | Timothy M Ebbels | Gregory J Stevens | Bruce D Car | Glenn H Cantor | Craig E. Thomas | Adrienne Tymiak | Goetz Schlotterbeck | Hans Senn | G. Cantor | Alan P Breau | U. Sidelmann | Goetz Schlotterbeck | G. Stevens | A. Breau | Donald Robertson | Roy H Bible | Ulla G Sidelmann | Steen M Laursen | Jean Marie Colet | Ali Loukaci | Craig Thomas | A. Loukaci | Peter Luke | S. Laursen
[1] John C. Lindon,et al. Cephaloridine-induced nephrotoxicity in the Fischer 344 rat: proton NMR spectroscopic studies of urine and plasma in relation to conventional clinical chemical and histopathological assessments of nephronal damage , 2005, Archives of Toxicology.
[2] J. Nicholson,et al. Proton NMR spectroscopic studies on the metabolism and biochemical effects of hydrazine in vivo , 2005, Archives of Toxicology.
[3] John A. Timbrell,et al. Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats , 2005, Archives of Toxicology.
[4] J. Nicholson,et al. Hepatotoxin-induced hypertaurinuria: a proton NMR study , 2005, Archives of Toxicology.
[5] T. Ebbels,et al. Analytical reproducibility in (1)H NMR-based metabonomic urinalysis. , 2002, Chemical research in toxicology.
[6] M. Reily,et al. Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats. , 2002, Toxicology and applied pharmacology.
[7] Timothy M. D. Ebbels,et al. Batch statistical processing of 1H NMR‐derived urinary spectral data , 2002 .
[8] Jianghua Feng,et al. 1H NMR analysis for metabolites in serum and urine from rats administrated chronically with La(NO3)3. , 2002, Analytical biochemistry.
[9] J. Lindon,et al. Metabonomics: a platform for studying drug toxicity and gene function , 2002, Nature Reviews Drug Discovery.
[10] Marilyn J Aardema,et al. Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies. , 2002, Mutation research.
[11] J. Mckim,et al. Strategic Importance of Research Support through Pathology , 2002, Toxicologic pathology.
[12] M. Reily,et al. NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse. , 2001, Journal of pharmaceutical and biomedical analysis.
[13] J. Griffin,et al. Metabolic profiling of chronic cadmium exposure in the rat. , 2001, Chemical research in toxicology.
[14] John C. Lindon,et al. Detection of in vivo biomarkers of phospholipidosis using NMR‐based metabonomic approaches , 2001 .
[15] E Holmes,et al. Metabonomic investigations into hydrazine toxicity in the rat. , 2001, Chemical research in toxicology.
[16] J G Bundy,et al. An NMR‐based metabonomic approach to the investigation of coelomic fluid biochemistry in earthworms under toxic stress , 2001, FEBS letters.
[17] E Holmes,et al. Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks. , 2001, Chemical research in toxicology.
[18] M. Reily,et al. Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.
[19] E Holmes,et al. Chemometric models for toxicity classification based on NMR spectra of biofluids. , 2000, Chemical research in toxicology.
[20] J. Nicholson,et al. A metabonomic approach to the investigation of drug-induced phospholipidosis: an NMR spectroscopy and pattern recognition study , 2000 .
[21] J. Lindon,et al. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.
[22] J. Lindon,et al. The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine , 1998 .
[23] E Holmes,et al. Development of a model for classification of toxin‐induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition , 1998, NMR in biomedicine.
[24] J C Lindon,et al. Biochemical classification of kidney carcinoma biopsy samples using magic-angle-spinning 1H nuclear magnetic resonance spectroscopy. , 1998, Journal of pharmaceutical and biomedical analysis.
[25] R. Gonzalez,et al. Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens. , 1998, Cancer research.
[26] E Holmes,et al. Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. , 1998, Chemical research in toxicology.
[27] D G Cory,et al. Gradient, high‐resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells , 1998, Magnetic resonance in medicine.
[28] M. Spraul,et al. High resolution magic angle spinning 1H nuclear magnetic resonance analysis of intact prostatic hyperplastic and tumour tissues , 1998 .
[29] D. Cory,et al. Gradient, high‐resolution, magic‐angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue , 1997, Magnetic resonance in medicine.
[30] R. Gonzalez,et al. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[31] M. Spraul,et al. Magic Angle Spinning Proton Nuclear Magnetic Resonance Spectroscopic Analysis of Intact Kidney Tissue Samples , 1997 .
[32] J L Ackerman,et al. Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic‐angle spinning , 1996, Magnetic resonance in medicine.
[33] I. Wilson,et al. Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide. , 1996, Therapeutic drug monitoring.
[34] J C Lindon,et al. Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network. , 1995, Journal of pharmaceutical and biomedical analysis.
[35] M. Spraul,et al. 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. , 1995, Analytical chemistry.
[36] J C Lindon,et al. Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine. , 1994, Molecular pharmacology.
[37] E Holmes,et al. Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine. , 1992, Molecular pharmacology.
[38] J. Nicholson,et al. Studies on the biochemical effects of the aldose reductase inhibitor 2,7-difluorospirofluorene-9,5'-imidazolidine-2',4'-dione (Al 1576, HOE 843). Detection of D-glucaric and D-glucuronic acid excretion by high resolution 1H and 13C NMR spectroscopy. , 1992, Biochemical pharmacology.
[39] J C Lindon,et al. Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine. , 1991, Molecular pharmacology.
[40] J C Lindon,et al. A pattern recognition approach to the comparison of PMR and clinical chemical data for classification of nephrotoxicity. , 1990, Journal of pharmaceutical and biomedical analysis.
[41] P J Sadler,et al. Quantitative high resolution 1H NMR urinalysis studies on the biochemical effects of cadmium in the rat. , 1989, Molecular pharmacology.
[42] J. Nicholson,et al. Investigations into the biochemical effects of region-specific nephrotoxins. , 1989, Molecular pharmacology.
[43] Ian D. Wilson,et al. HIGH RESOLUTION PROTON MAGNETIC RESONANCE SPECTROSCOPY OF BIOLOGICAL FLUIDS , 1989 .
[44] P J Sadler,et al. Proton NMR spectra of urine as indicators of renal damage. Mercury-induced nephrotoxicity in rats. , 1985, Molecular pharmacology.
[45] P. Turner,et al. The effect of amphetamine on glucose uptake into the rat isolated hemidiaphragm , 1974, The Journal of pharmacy and pharmacology.
[46] Amenta Js,et al. Hydrazine-induced alterations in rat liver. A correlation of the chemical and histologic changes in acute hydrazine intoxication. , 1962 .