Effects of supplementation with milk protein on glycemic parameters: a GRADE-assessed systematic review and dose–response meta-analysis

[1]  Zahra Namkhah,et al.  The effects of vitamin C supplementation on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. , 2023, Diabetes & metabolic syndrome.

[2]  J. Lesgards.  Benefits of Whey Proteins on Type 2 Diabetes Mellitus Parameters and Prevention of Cardiovascular Diseases , 2023, Nutrients.

[3]  T. Huppertz,et al.  Glycemic Responses of Milk and Plant-Based Drinks: Food Matrix Effects , 2023, Foods.

[4]  Yucheng Yang,et al.  Association between dairy consumption and the risk of diabetes: A prospective cohort study from the China Health and Nutrition Survey , 2022, Frontiers in Nutrition.

[5]  P. C. Lobo,et al.  Effects of whey protein supplementation on adiposity, body weight, and glycemic parameters: A synthesis of evidence. , 2022, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[6]  J. Norberto Pires,et al.  A Novel Plant-Based Protein Has Similar Effects Compared to Whey Protein on Body Composition, Strength, Power, and Aerobic Performance in Professional and Semi-Professional Futsal Players , 2022, Frontiers in Nutrition.

[7]  Bahram Pourghassem Gargari,et al.  A systematic review of whey protein supplementation effects on human glycemic control: A mechanistic insight. , 2022, Diabetes & metabolic syndrome.

[8]  T. Huppertz,et al.  Milk proteins: Processing, gastric coagulation, amino acid availability and muscle protein synthesis , 2022, Critical reviews in food science and nutrition.

[9]  Hye-Yoon Jeon,et al.  Polymer-Based Delivery of Peptide Drugs to Treat Diabetes: Normalizing Hyperglycemia and Preventing Diabetic Complications , 2022, BioChip Journal.

[10]  Michael L. Mullan.  Understanding and Improving the Functional and Nutritional Properties of milk. Edited by Professor ThomHuppertz and Professor TodorVasiljevic. Burleigh Dodds Science Publishing Limited, Cambridge, UK. 2022. 774 pages. £160. ISBN‐13: 9781786768193. Also available as an E‐book. , 2022, International Journal of Dairy Technology.

[11]  E. Loh,et al.  Whey protein supplementation improves postprandial glycemia in persons with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. , 2022, Nutrition research.

[12]  T. Vasiljevic.  Understanding and improving the functional and nutritional properties of milk , 2022, Burleigh Dodds Series in Agricultural Science.

[13]  M. Fukui,et al.  Fasting plasma glucose level in the range of 90–99 mg/dL and the risk of the onset of type 2 diabetes: Population‐based Panasonic cohort study 2 , 2021, Journal of diabetes investigation.

[14]  R. Bagheri,et al.  Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials , 2021, Nutrients.

[15]  B. Ekblom,et al.  Six Weeks of Aerobic Exercise in Untrained Men With Overweight/Obesity Improved Training Adaptations, Performance and Body Composition Independent of Oat/Potato or Milk Based Protein-Carbohydrate Drink Supplementation , 2021, Frontiers in Nutrition.

[16]  Hirofumi Tanaka,et al.  Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia , 2020, Nutrients.

[17]  Michael J. González,et al.  Effect of green tea on glycemic control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. , 2020, Diabetes & metabolic syndrome.

[18]  M. Mansournia,et al.  Effects of whey protein on glycemic control and serum lipoproteins in patients with metabolic syndrome and related conditions: a systematic review and meta-analysis of randomized controlled clinical trials , 2020, Lipids in health and disease.

[19]  J. Holst,et al.  Effects of whey protein and dietary fiber intake on insulin sensitivity, body composition, energy expenditure, blood pressure, and appetite in subjects with abdominal obesity , 2020, European Journal of Clinical Nutrition.

[20]  E. Mayo-Wilson,et al.  The PRISMA 2020 statement: an updated guideline for reporting systematic reviews , 2020, BMJ.

[21]  N. Burd,et al.  Does high dietary protein intake contribute to the increased risk of developing prediabetes and type 2 diabetes? , 2020, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[22]  M. Asghari-Jafarabadi,et al.  Whey protein supplementation reducing fasting levels of anandamide and 2-AG without weight loss in pre-menopausal women with obesity on a weight-loss diet , 2020, Trials.

[23]  K. Heffernan,et al.  Effects of Whey Protein Supplementation on Aortic Stiffness, Cerebral Blood Flow, and Cognitive Function in Community-Dwelling Older Adults: Findings from the ANCHORS A-WHEY Clinical Trial , 2020, Nutrients.

[24]  A. Chaimani,et al.  Challenges in meta-analyses with observational studies , 2020, Evidence-Based Mental Health.

[25]  W. Campbell,et al.  Incorporating Milk Protein Isolate into an Energy-Restricted Western-Style Eating Pattern Augments Improvements in Blood Pressure and Triglycerides, but Not Body Composition Changes in Adults Classified as Overweight or Obese: A Randomized Controlled Trial , 2020, Nutrients.

[26]  A. D'Angelo,et al.  Change of some oxidative stress parameters after supplementation with whey protein isolate in patients with type 2 diabetes. , 2019, Nutrition.

[27]  R. Govender,et al.  Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends , 2019, Journal of epidemiology and global health.

[28]  K. Hidayat,et al.  Milk in the prevention and management of type 2 diabetes: The potential role of milk proteins , 2019, Diabetes/metabolism research and reviews.

[29]  C. Gurrola-Díaz,et al.  The Importance of Lactose in the Human Diet: Outcomes of a Mexican Consensus Meeting , 2019, Nutrients.

[30]  C. Pichard,et al.  Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study , 2019, Nutrients.

[31]  Natalie S Blencowe,et al.  RoB 2: a revised tool for assessing risk of bias in randomised trials , 2019, BMJ.

[32]  L. Sardinha,et al.  Effect of whey protein supplementation combined with resistance training on body composition, muscular strength, functional capacity, and plasma-metabolism biomarkers in older women with sarcopenic obesity: A randomized, double-blind, placebo-controlled trial. , 2019, Clinical nutrition ESPEN.

[33]  Zengning Li,et al.  Effect of whey protein on blood pressure in pre‐ and mildly hypertensive adults: A randomized controlled study , 2019, Food science & nutrition.

[34]  B. Bibby,et al.  Effect of a Whey Protein Supplement on Preservation of Fat Free Mass in Overweight and Obese Individuals on an Energy Restricted Very Low Caloric Diet , 2018, Nutrients.

[35]  C. la Vecchia,et al.  Cow’s Milk Consumption and Health: A Health Professional’s Guide , 2018, Journal of the American College of Nutrition.

[36]  Y. Xiang,et al.  Dietary protein intake and risk of type 2 diabetes: a dose–response meta-analysis of prospective studies , 2018, European Journal of Nutrition.

[37]  E. Stevenson,et al.  A small dose of whey protein co-ingested with mixed-macronutrient breakfast and lunch meals improves postprandial glycemia and suppresses appetite in men with type 2 diabetes: a randomized controlled trial. , 2018, The American journal of clinical nutrition.

[38]  F. Hassan,et al.  Does whey protein supplementation affect blood pressure in hypoalbuminemic peritoneal dialysis patients? , 2017, Therapeutics and clinical risk management.

[39]  David M. Rocke,et al.  Glucose-lowering effect of whey protein depends upon clinical characteristics of patients with type 2 diabetes , 2017, BMJ Open Diabetes Research & Care.

[40]  J. Kerstetter,et al.  The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial , 2017, Nutrients.

[41]  Matthew H Sharp,et al.  The Effects of Beef, Chicken, or Whey Protein After Workout on Body Composition and Muscle Performance , 2017, Journal of strength and conditioning research.

[42]  B. D’Agord Schaan,et al.  Whey Protein Supplementation Enhances Body Fat and Weight Loss in Women Long After Bariatric Surgery: a Randomized Controlled Trial , 2017, Obesity Surgery.

[43]  Jeffrey R Stout,et al.  Effects of Hydrolyzed Whey versus Other Whey Protein Supplements on the Physiological Response to 8 Weeks of Resistance Exercise in College-Aged Males , 2017, Journal of the American College of Nutrition.

[44]  D. I. Givens,et al.  Whey protein lowers blood pressure and improves endothelial function and lipid biomarkers in adults with prehypertension and mild hypertension: results from the chronic Whey2Go randomized controlled trial12 , 2016, The American journal of clinical nutrition.

[45]  K. Broughton,et al.  Insulinotropic Effects of Whey: Mechanisms of Action, Recent Clinical Trials, and Clinical Applications , 2016, Annals of Nutrition and Metabolism.

[46]  I. Dionne,et al.  The Effect of Resistance Training and Different Sources of Postexercise Protein Supplementation on Muscle Mass and Physical Capacity in Sarcopenic Elderly Men , 2016, Journal of strength and conditioning research.

[47]  R. Edmonds,et al.  Protein-Pacing from Food or Supplementation Improves Physical Performance in Overweight Men and Women: The PRISE 2 Study , 2016, Nutrients.

[48]  K. Nugent,et al.  The Effect of Short‐Term Hyperglycemia on the Innate Immune System , 2016, The American journal of the medical sciences.

[49]  F. Shidfar,et al.  Beneficial effects of whey protein preloads on some cardiovascular diseases risk factors of overweight and obese men are stronger than soy protein preloads – A randomized clinical trial , 2015 .

[50]  A. Nongonierma,et al.  Bioactive properties of milk proteins in humans: A review , 2015, Peptides.

[51]  K. Comerford,et al.  Dairy Foods and Dairy Proteins in the Management of Type 2 Diabetes: A Systematic Review of the Clinical Evidence12 , 2015, Advances in nutrition.

[52]  O. Fiehn,et al.  Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial. , 2015, The Journal of nutrition.

[53]  H. Bilo,et al.  Differences in interpretation of haemoglobin A1c values among diabetes care professionals. , 2014, The Netherlands journal of medicine.

[54]  T. Akhavan,et al.  Mechanism of action of whole milk and its components on glycemic control in healthy young men. , 2014, The Journal of nutritional biochemistry.

[55]  M. Boaz,et al.  Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial , 2014, Diabetologia.

[56]  M. Hagger,et al.  Comparative effects of whey and casein proteins on satiety in overweight and obese individuals: a randomized controlled trial , 2014, European Journal of Clinical Nutrition.

[57]  Alison B. Evert,et al.  Nutrition Therapy Recommendations for the Management of Adults With Diabetes , 2013, Diabetes Care.

[58]  Vassilios Raikos,et al.  Health-promoting properties of bioactive peptides derived from milk proteins in infant food: a review , 2013, Dairy science & technology.

[59]  L. Chan.  Minimal clinically important difference (MCID)--adding meaning to statistical inference. , 2013, American journal of public health.

[60]  S. Poppitt,et al.  Milk protein for improved metabolic health: a review of the evidence , 2013, Nutrition & Metabolism.

[61]  E. Östman,et al.  Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose–response study , 2013, European Journal of Clinical Nutrition.

[62]  Gigi Foster.  Interpreting and Visualizing Regression Models Using Stata, by Michael N. Mitchell (Stata Press, College Station, Texas, 2012), pp. xxix + 558 , 2013 .

[63]  D. S. Vatani,et al.  Changes in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance training , 2012, Appetite.

[64]  F. Nystrom,et al.  A randomized trial of protein supplementation compared with extra fast food on the effects of resistance training to increase metabolism , 2012, Scandinavian journal of clinical and laboratory investigation.

[65]  Michael N. Mitchell.  Interpreting and Visualizing Regression Models Using Stata , 2012 .

[66]  Mikko P. Björkman,et al.  Whey protein supplementation in nursing home residents. A randomized controlled trial , 2012 .

[67]  H. Predel,et al.  The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised placebo-controlled trial , 2011, British Journal of Nutrition.

[68]  Y. Uehara,et al.  Randomized, double-blind, controlled, comparative trial of formula food containing soy protein vs. milk protein in visceral fat obesity. -FLAVO study-. , 2011, Circulation journal : official journal of the Japanese Circulation Society.

[69]  O. Hamdy,et al.  Protein Content in Diabetes Nutrition Plan , 2011, Current diabetes reports.

[70]  S. Pal,et al.  Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women. , 2010, Atherosclerosis.

[71]  J H Devries,et al.  Hyperglycemia: a prothrombotic factor? , 2010, Journal of thrombosis and haemostasis : JTH.

[72]  A. Smith‐Ryan,et al.  The Effects of Pre- and Post-Exercise Whey vs. Casein Protein Consumption on Body Composition and Performance Measures in Collegiate Female Athletes. , 2010, Journal of sports science & medicine.

[73]  J. Danesh,et al.  Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review , 2010, PLoS medicine.

[74]  M. França,et al.  Effect of nutritional supplementation with milk whey proteins in amyotrophic lateral sclerosis patients. , 2010, Arquivos de neuro-psiquiatria.

[75]  Hannah R Rothstein,et al.  A basic introduction to fixed‐effect and random‐effects models for meta‐analysis , 2010, Research synthesis methods.

[76]  V. Vuksan,et al.  A whey protein supplement decreases post-prandial glycemia , 2009, Nutrition journal.

[77]  P. Clifton,et al.  Effects of a Protein Preload on Gastric Emptying, Glycemia, and Gut Hormones After a Carbohydrate Meal in Diet-Controlled Type 2 Diabetes , 2009, Diabetes Care.

[78]  L. Hedges,et al.  Introduction to Meta‐Analysis , 2009, International Coaching Psychology Review.

[79]  D. Tomé,et al.  Protein, amino acids and the control of food intake , 2004, British Journal of Nutrition.

[80]  P. Clifton,et al.  The effect of meal replacements high in glycomacropeptide on weight loss and markers of cardiovascular disease risk. , 2008, The American journal of clinical nutrition.

[81]  D. Aronson.  Hyperglycemia and the pathobiology of diabetic complications. , 2008, Advances in cardiology.

[82]  H. Hauner,et al.  Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension , 2007, European journal of nutrition.

[83]  J. Holst,et al.  Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects. , 2005, The American journal of clinical nutrition.

[84]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[85]  Wim H M Saris,et al.  Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes. , 2003, Diabetes care.

[86]  W. Hall,et al.  Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite , 2003, British Journal of Nutrition.

[87]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[88]  C. Begg,et al.  Publication bias : a problem in interpreting medical data , 1988 .

[89]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[90]  J. Faulkner,et al.  Nil Whey Protein Effect on Glycemic Control after Intense Mixed-Mode Training in Type 2 Diabetes. , 2017, Medicine and science in sports and exercise.

[91]  A. Mortazavian,et al.  Health-Related Aspects of Milk Proteins , 2016, Iranian journal of pharmaceutical research : IJPR.

[92]  L. Andersen,et al.  Intake of a protein-enriched milk and effects on muscle mass and strength. A 12-week randomized placebo controlled trial among community-dwelling older adults , 2016, The journal of nutrition, health & aging.

[93]  T. Akhavan,et al.  Mechanism of action of pre-meal consumption of whey protein on glycemic control in young adults. , 2014, The Journal of nutritional biochemistry.

[94]  A. Mariani,et al.  Observational studies: why are they so important? , 2014, Sao Paulo medical journal = Revista paulista de medicina.

[95]  G. Umpierrez,et al.  Patient guide to managing hyperglycemia (high blood sugar) in the hospital. , 2012, The Journal of clinical endocrinology and metabolism.

[96]  D. Sheikholeslami Vatani,et al.  Changes in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance training. , 2012, Appetite.

[97]  B. Balkau,et al.  Dairy consumption and the incidence of hyperglycaemia and the metabolic syndrome : results from a French prospective study , 2011 .

[98]  M. Claessens,et al.  The effect of a low-fat, high-protein or high-carbohydrate ad libitum diet on weight loss maintenance and metabolic risk factors , 2009, International Journal of Obesity.

[99]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[100]  Bias in meta›analysis detected by a simple, graphical test , 1998 .

[101]  GrADE: an emerging consensus on rating quality of evidence and strength of recommendations , 2022 .