A newborn with moderate hemophilia A with severe intracranial and extracranial hemorrhage: A case report

Intracranial hemorrhage among term newborns is a rare clinical condition with high morbidity and mortality. Although major bleeding is relatively uncommon, the incidence of intracranial hemorrhage in hemophilic children is higher during the first few days of life than at any other stage in childhood, which relates to the trauma of delivery. Here, we reported a newborn case diagnosed with moderate hemophilia A, without the presence of a positive family history of hemophilia and presenting with intracranial and extracranial hemorrhage and we aimed to emphasize that the early diagnosis and replacement therapy carries an essential importance.

[1]  A. Coskun,et al.  Intracranial hemorrhage in children with congenital factor deficiencies , 2011, Child's Nervous System.

[2]  B. Konkle,et al.  Surveillance of female patients with inherited bleeding disorders in United States Haemophilia Treatment Centres , 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

[3]  K. Khair,et al.  Long‐term consequences of intracranial haemorrhage in children with haemophilia , 2009, Haemophilia : the official journal of the World Federation of Hemophilia.

[4]  J. Maahs,et al.  Practice patterns in haemophilia A therapy – global progress towards optimal care , 2006, Haemophilia : the official journal of the World Federation of Hemophilia.

[5]  F. Rosendaal,et al.  Definitions in Hemophilia , 2001, Thrombosis and Haemostasis.

[6]  J. Lusher,et al.  Perinatal management of newborns with haemophilia , 2001, British journal of haematology.

[7]  W. Kreuz,et al.  Prevalence and outcome of intracranial haemorrhage in haemophiliacs – a survey of the paediatric group of the German Society of Thrombosis and Haemostasis (GTH) , 1999, European Journal of Pediatrics.

[8]  J. Lusher,et al.  Intracranial and extracranial hemorrhages in newborns with hemophilia: a review of the literature. , 1999, Journal of pediatric hematology/oncology.

[9]  M. Horgan,et al.  Splenic Rupture in a Newborn with Hemophilia A: Case Report and Revew of the Literature , 1999, Clinical pediatrics.

[10]  Laurian,et al.  Haemophilia A: two cases showing unusual features at birth , 1998, Haemophilia : the official journal of the World Federation of Hemophilia.

[11]  J. Kurinczuk,et al.  Neonatal subgaleal haematoma: Associated risk factors, complications and outcome , 1996, Journal of paediatrics and child health.

[12]  A. Giles,et al.  The Canadian Hemophilia Registry as the basis for a national system for monitoring the use of factor concentrates , 1995, Transfusion.

[13]  R. Ljung,et al.  Normal vaginal delivery is to be recommended for haemophilia carrier gravidae , 1994, Acta paediatrica.

[14]  D. Bentley,et al.  Genetics and molecular biology of haemophilias A and B. , 1991, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[15]  R. Lawn The molecular genetics of hemophilia: Blood clotting factors VIII and IX , 1985, Cell.

[16]  C. Fawer,et al.  Risk factors in the development of intraventricular haemorrhage in the preterm neonate. , 1982, Archives of disease in childhood.

[17]  W. Plauché Subgaleal hematoma. A complication of instrumental delivery. , 1980, JAMA.

[18]  M. Hilgartner,et al.  Central nervous system bleeding in hemophiliacs. , 1978, Blood.

[19]  H. Strauss,et al.  Hemophilia in the first year of life. , 1966, The New England journal of medicine.