WAGNER‐NELSON METHOD FOR ANALYSING THE ATYPICAL DOUBLE‐PEAKED [13CO2] EXCRETION CURVE IN THE [13C]‐OCTANOATE GASTRIC EMPTYING BREATH TEST IN HUMANS

1. In the [13C]‐octanoic acid breath test, the time versus pulmonary [13CO2] excretion rate curve is analysed using mathematical curve‐fitting techniques to calculate gastric emptying parameters. Thus, the goodness‐of‐fit highly influences the accuracy of the breath test. However, a double‐peaked [13CO2] excretion curve, which occasionally develops owing to the presence of an interval of quiescent gastric emptying (the plateau phase), is likely to be fitted poorly.

[1]  M. Sanaka,et al.  Modified 13C-Octanoate Breath Test and Impact of Sampling Points , 2004, Journal of clinical gastroenterology.

[2]  P. Rutgeerts,et al.  Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. , 1993, Gastroenterology.

[3]  J. Fleming,et al.  The influence of levodopa on gastric emptying in man. , 1990, British journal of clinical pharmacology.

[4]  L F Prescott,et al.  Kinetics of acetaminophen absorption and gastric emptying in man , 1978, Clinical pharmacology and therapeutics.

[5]  J. Roberts,et al.  The effects of co-administration of benzhexol on the peripheral pharmacokinetics of oral levodopa in young volunteers. , 2003, British journal of clinical pharmacology.

[6]  M. Sanaka,et al.  Theoretical Flaws in the Gastric Emptying Breath Test: Why is it Dubious? , 2005, Digestive Diseases and Sciences.

[7]  P. Rutgeerts,et al.  Pharmacological modulation of gastric emptying rate of solids as measured by the carbon labelled octanoic acid breath test: influence of erythromycin and propantheline. , 1994, Gut.

[8]  T. Omari,et al.  Assessment Of Gastric Emptying In The Mouse Using The [13C]‐Octanoic Acid Breath Test , 2000, Clinical and experimental pharmacology & physiology.

[9]  13C-octanoic acid breath test: a reliable tool for measuring gastric emptying. , 1998, Italian journal of gastroenterology and hepatology.

[10]  Gordon L. Amidon,et al.  Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs , 1995, Pharmaceutical Research.

[11]  M. Sanaka,et al.  The Wagner-Nelson Method Can Generate an Accurate Gastric Emptying Flow Curve from 13CO2 Data Obtained by a 13C-Labeled Substrate Breath Test , 2004, Digestion.

[12]  G. Amidon,et al.  Variable gastric emptying and discontinuities in drug absorption profiles: Dependence of rates and extent of cimetidine absorption on motility phase and pH , 1994, Biopharmaceutics & drug disposition.

[13]  P. Christian,et al.  Variability of gastric emptying measurements in man employing standardized radiolabeled meals , 1986, Digestive Diseases and Sciences.

[14]  D. Harron.  Clinical pharmacokinetics: Concepts and applications (2nd edn.) , 1989 .

[15]  J. Wagner,et al.  KINETIC ANALYSIS OF BLOOD LEVELS AND URINARY EXCRETION IN THE ABSORPTIVE PHASE AFTER SINGLE DOSES OF DRUG. , 1964, Journal of pharmaceutical sciences.

[16]  Masami Yamanaka,et al.  Guide for judicious use of the paracetamol absorption technique in a study of gastric emptying rate of liquids , 1998, Journal of Gastroenterology.