Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.
暂无分享,去创建一个
C. Supuran | F. Carta | R. McKenna | M. Sechi | N. Pala | M. Aggarwal | Laura Micheletto
[1] C. Supuran,et al. A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors. , 2014, Angewandte Chemie.
[2] C. D. Boone,et al. Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. , 2013, Bioorganic & medicinal chemistry.
[3] C. Supuran,et al. 5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies. , 2013, Bioorganic & medicinal chemistry.
[4] C. Supuran,et al. Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors. , 2013, Chemical communications.
[5] C. Supuran. Structure-based drug discovery of carbonic anhydrase inhibitors , 2012, Journal of enzyme inhibition and medicinal chemistry.
[6] F. Da Settimo,et al. Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms. , 2012, Journal of medicinal chemistry.
[7] C. Supuran,et al. Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? , 2012, Chemical reviews.
[8] C. Supuran,et al. Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II. , 2011, Chemical communications.
[9] C. Supuran,et al. Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. , 2011, Journal of medicinal chemistry.
[10] C. Supuran,et al. Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms. , 2011, Bioorganic & medicinal chemistry.
[11] Vladimir Garaj,et al. Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. , 2011, Bioorganic & medicinal chemistry.
[12] C. Supuran,et al. Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. , 2010, Bioorganic & medicinal chemistry letters.
[13] Brendan L Wilkinson,et al. Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. , 2008, Journal of medicinal chemistry.
[14] Claudiu T. Supuran,et al. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators , 2008, Nature Reviews Drug Discovery.
[15] Brendan L Wilkinson,et al. Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides. , 2007, Journal of medicinal chemistry.
[16] Chi-Huey Wong,et al. In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II. , 2004, Angewandte Chemie.
[17] C. Supuran,et al. Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action. , 2000, Journal of medicinal chemistry.