Comparison of physiological and post-endovascular aneurysm repair infrarenal blood flow

Abstract Endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms results in redirection of blood through the deployed endograft (EG). Even though EVAR is clinically effective, the absolute flow restoration is not warranted. Our purpose was to compare the physiological with the post-EVAR infrarenal flow conditions. We developed patient-specific models based on computed tomography data of five healthy volunteers and ten patients treated with the Endurant® stent-graft system. Wall shear stress (WSS), helicity, pressure and velocity fields were calculated using computational fluid dynamics. The results showed a decrease of peak WSS on the part of the EG that resides in the iliac arteries, compared to the physiological value (p = 0.01). At the abdominal part, the average helicity seems to increase after EVAR, while at the iliac arteries part, the intensity of helical flow seems physiological. Pressure drop and peak velocity in the iliac arteries part are lower than the physiological values (p = 0.04). The comparison revealed that most hemodynamic properties converge to normal levels at the abdominal part whereas statistically significant variations were observed in the iliac arteries part. The delineation of the differences between physiological and postoperative flow data could pave the way for the improvement of EG designs.

[1]  Charles A. Taylor,et al.  Endovascular Device Design in the Future: Transformation from Trial and Error to Computational Design , 2009, Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists.

[2]  N. Stergiopulos,et al.  Impact of aortic grafts on arterial pressure: a computational fluid dynamics study. , 2011, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[3]  Christodoulos Stefanadis,et al.  Vascular wall shear stress: basic principles and methods. , 2005, Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese.

[4]  S Baek,et al.  Intrasac pressure changes and vascular remodeling after endovascular repair of abdominal aortic aneurysms: review and biomechanical model simulation. , 2011, Journal of biomechanical engineering.

[5]  Pierce A Grace,et al.  A Review of the in Vivo and in Vitro Biomechanical Behavior and Performance of Postoperative Abdominal Aortic Aneurysms and Implanted Stent-Grafts , 2008, Journal of Endovascular Therapy.

[6]  Miguel Castro,et al.  Prediction of deformations during endovascular aortic aneurysm repair using finite element simulation , 2013, Comput. Medical Imaging Graph..

[7]  M. Cadioli,et al.  In Vivo Quantification of Helical Blood Flow in Human Aorta by Time-Resolved Three-Dimensional Cine Phase Contrast Magnetic Resonance Imaging , 2009, Annals of Biomedical Engineering.

[8]  Alexander M. Seifalian,et al.  AAA Stent–Grafts: Past Problems and Future Prospects , 2010, Annals of Biomedical Engineering.

[9]  E. Georgakarakos,et al.  Application of Bioengineering Modalities in Vascular Research: Evaluating the Clinical Gain , 2012, Vascular and endovascular surgery.

[10]  M. Olufsen,et al.  Numerical Simulation and Experimental Validation of Blood Flow in Arteries with Structured-Tree Outflow Conditions , 2000, Annals of Biomedical Engineering.

[11]  Simon Wildermuth,et al.  Computational Fluid Dynamics: Hemodynamic Changes in Abdominal Aortic Aneurysm After Stent-Graft Implantation , 2005, CardioVascular and Interventional Radiology.

[12]  Charles A. Taylor,et al.  In vitro validation of finite-element model of AAA hemodynamics incorporating realistic outlet boundary conditions. , 2011, Journal of biomechanical engineering.

[13]  T. Christian Gasser,et al.  Hemodynamics of the Normal Aorta Compared to Fusiform and Saccular Abdominal Aortic Aneurysms with Emphasis on a Potential Thrombus Formation Mechanism , 2010, Annals of Biomedical Engineering.

[14]  Pascal Verdonck,et al.  Intraluminal thrombus and risk of rupture in patient specific abdominal aortic aneurysm - FSI modelling. , 2009, Computer methods in biomechanics and biomedical engineering.

[15]  J. Chevalier,et al.  Effect of abdominal aortic grafts on aortic stiffness and central hemodynamics , 2009, Journal of hypertension.

[16]  Frans L. Moll,et al.  Endovascular treatment of abdominal aortic aneurysms , 2014, Nature Reviews Cardiology.

[17]  C. Kleinstreuera,et al.  Computational mechanics of Nitinol stent grafts , 2008 .

[18]  M. Cadioli,et al.  Mechanistic insight into the physiological relevance of helical blood flow in the human aorta: an in vivo study , 2011, Biomechanics and modeling in mechanobiology.

[19]  Liam Morris,et al.  Stent graft performance in the treatment of abdominal aortic aneurysms: the influence of compliance and geometry. , 2013, Journal of biomechanics.

[20]  Yubo Fan,et al.  Physiological Significance of Helical Flow in the Arterial System and its Potential Clinical Applications , 2014, Annals of Biomedical Engineering.

[21]  C. K. Chong,et al.  Flow patterns in an endovascular stent-graft for abdominal aortic aneurysm repair. , 2004, Journal of biomechanics.

[22]  T. Christian Gasser,et al.  Blood flow and coherent vortices in the normal and aneurysmatic aortas: a fluid dynamical approach to intra-luminal thrombus formation , 2011, Journal of The Royal Society Interface.

[23]  Mark J Sculpher,et al.  Endovascular versus Open Repair of Abdominal Aortic Aneurysm , 2011 .

[24]  M. Xenos,et al.  Comparative study of flow in right-sided and left-sided aortas: numerical simulations in patient-based models , 2015, Computer methods in biomechanics and biomedical engineering.

[25]  Richard J. Lozowy,et al.  Low wall shear stress predominates at sites of abdominal aortic aneurysm rupture. , 2015, Journal of vascular surgery.

[26]  Shmuel Einav,et al.  Progression of Abdominal Aortic Aneurysm Towards Rupture: Refining Clinical Risk Assessment Using a Fully Coupled Fluid–Structure Interaction Method , 2014, Annals of Biomedical Engineering.

[27]  Xiao Yun Xu,et al.  Patient-specific analysis of displacement forces acting on fenestrated stent grafts for endovascular aneurysm repair. , 2014, Journal of biomechanics.

[28]  J. Moore,et al.  Flow changes in the aorta associated with the deployment of a AAA stent graft. , 2003, Medical engineering & physics.