Rat parotid gland pathophysiology following 137Cs irradiation.

Changes in rat parotid gland function were measured between 3 and 30 days following exposure to 1800 R of137 Cs irradiation to the head. Glandular fluid secretion capability as indicated by volume of secretion, maximum rate of secretion, and duration of secretion following pilocarpine stimulation decreased concomitantly with gland weight following irradiation. Thus gland weight is probably indicative of residual glandular potential for fluid secretion following irradiation. The relation between salivary sodium concentration and flow rate was assumed to be indicative of glandular electrolyte transport capability. Salivary sodium concentrations were not elevated over control values at any flow rate. Therefore, there is no evidence for an irradiation-induced defect in the ductal sodium resorption mechanism. Rather, the observed salivary sodium changes are consistent with a decrease in the relative glandular proportion of acini to ducts.

[1]  J. C. Rice,et al.  Parotid gland pathophysiology after mixed gamma and neutron irradiation of cancer patients. , 1981, Oral surgery, oral medicine, and oral pathology.

[2]  J. C. Rice,et al.  Whole saliva albumin as an indicator of stomatitis in cancer therapy patients , 1981, Cancer.

[3]  T. Sasaki,et al.  Function of parotid gland following irradiation and its relation to biological parameters. , 1980, Radiation research.

[4]  M. Davis,et al.  Radioprotection of the rat parotid gland by WR-2721: morphology at 60 days post-irradiation. , 1980, International journal of radiation oncology, biology, physics.

[5]  I. Mandel.  Sialochemistry in diseases and clinical situations affecting salivary glands. , 1980, Critical reviews in clinical laboratory sciences.

[6]  A. D. Conger,et al.  Radioprotection by WR-2721 against long-term chronic damage to the rat parotid gland. , 1978, Radiation research.

[7]  C. Dawes,et al.  The influence of gland size on the flow rate and composition of human parotid saliva. , 1978, Dental journal.

[8]  M. Sholley,et al.  Effects of x-irradiation and the resultant inanition on amylase content of the rat parotid gland. , 1977, Archives of oral biology.

[9]  J. E. Turner,et al.  Electron microscopic changes in rat parotid and submandibular glands subsequent total body irradiation with fast neutrons. , 1976, Oral surgery, oral medicine, and oral pathology.

[10]  B. Levy,et al.  Radiation‐induced xerostomia in cancer patients. Effect on salivary and serum electrolytes , 1976, Cancer.

[11]  D. Laufer,et al.  Effects of irradiation on saliva in cancer patients. , 1975, International journal of oral surgery.

[12]  M. Sholley,et al.  Early radiation injury in the rat parotid gland. Reaction of acinar cells and vascular endothelium. , 1974, Laboratory investigation; a journal of technical methods and pathology.

[13]  P. Jakobsson,et al.  Effect of fractionated radiotherapy on salivary gland function , 1972, Cancer.

[14]  N. Pratt,et al.  Ultrastructural injury following x-irradiation of rat parotid gland acinar cells. , 1972, Archives of oral biology.

[15]  J. Young,et al.  Salivary secretion of electrolytes. , 1972, Physiological reviews.

[16]  B. Epker,et al.  Effects of fractionated doses of cobalt 60 irradiation on rabbit submandibular glands: light microscopic studies. , 1972, The Journal of Oral Surgery.

[17]  R. Phillips.  X-ray-induced changes in function and structure of the rat parotid gland. , 1970, Journal of oral surgery.

[18]  S. Levitt,et al.  Histologic effect of fractionated doses of selectively applied megavoltage irradiation on the major salivary glands of the albino rat. , 1969, Radiology.

[19]  P. Benke,et al.  A Sodium Transport Inhibitory Factor in the Saliva of Patients with Cystic Fibrosis of the Pancreas , 1967, Pediatric Research.

[20]  M. Itô.  Biological effects of x-irradiation on salivary glands of mice. , 1967, Radiation research.

[21]  H. Awad,et al.  Effect of x-irradiation on Na and K secretion by human parotid gland. , 1962, Journal of applied physiology.

[22]  B. L. Henriques.  Acinar-duct transport sites for Na+ and K+ in dog submaxillary salivary gland , 1961 .

[23]  A. Glucksmann,et al.  Injury and repair following irradiation of salivary glands in male rats. , 1959, The British journal of radiology.

[24]  W. G. Shafer.  The Effect of Single and Fractionated Doses of Selectively Applied X-Ray Irradiation On the Histologic Structure of the Major Salivary Glands of the Rat , 1953, Journal of dental research.