The Genetics of Brain Wiring: From Molecule to Mind

What makes some people neurotic or schizophrenic or right-handed or fearless? The challenge in answering this is to map from genotype to anatomical and physiological phenotypes and beyond to behavior and cognition.

[1]  C. Goodman,et al.  Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation , 1994, Neuron.

[2]  C. Waddington,et al.  The strategy of the genes , 1957 .

[3]  Hiroaki Kitano,et al.  Biological robustness , 2008, Nature Reviews Genetics.

[4]  R. Greenspan,et al.  The nature of genetic influences on behavior: lessons from "simpler" organisms. , 2006, The American journal of psychiatry.

[5]  T. Bouchard,et al.  Genetic and environmental influences on human psychological differences. , 2003, Journal of neurobiology.

[6]  Paul J. Harrison.  Schizophrenia: a disorder of neurodevelopment? , 1997, Current Opinion in Neurobiology.

[7]  David M. Evans,et al.  Two-Stage Two-Locus Models in Genome-Wide Association , 2006, PLoS genetics.

[8]  O. Marín,et al.  Tangential Neuronal Migration Controls Axon Guidance: A Role for Neuregulin-1 in Thalamocortical Axon Navigation , 2006, Cell.

[9]  A. Bailey,et al.  Autism as a strongly genetic disorder: evidence from a British twin study , 1995, Psychological Medicine.

[10]  G Tononi,et al.  Measures of degeneracy and redundancy in biological networks. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Therese Ann Markow,et al.  Fluctuating dermatoglyphic asymmetry and the genetics of liability to schizophrenia , 1986, Psychiatry Research.

[12]  K. Zinn,et al.  Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila. , 1997, Development.

[13]  N. Martin,et al.  Widespread Evidence for Non-Additive Genetic Variation in Cloninger’s and Eysenck’s Personality Dimensions using a Twin Plus Sibling Design , 2005, Behavior genetics.

[14]  Arturas Petronis,et al.  Phenotypic differences in genetically identical organisms: the epigenetic perspective. , 2005, Human molecular genetics.

[15]  Daniel R. Weinberger,et al.  Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia , 2007, Human Genetics.

[16]  Bruno van Swinderen,et al.  Flexibility in a Gene Network Affecting a Simple Behavior in Drosophila melanogaster , 2005, Genetics.

[17]  D. Wahlsten,et al.  Recombinant inbreeding in mice reveals thresholds in embryonic corpus callosum development , 2006, Genes, brain, and behavior.

[18]  Scott M. Williams,et al.  Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis. , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

[19]  C. Shatz,et al.  Subplate neurons pioneer the first axon pathway from the cerebral cortex. , 1989, Science.

[20]  A. Wagner.  Distributed robustness versus redundancy as causes of mutational robustness. , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

[21]  A. B. Huber,et al.  Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. , 2003, Annual review of neuroscience.

[22]  E. Marder,et al.  Variability, compensation and homeostasis in neuron and network function , 2006, Nature Reviews Neuroscience.

[23]  T. Elston,et al.  Stochasticity in gene expression: from theories to phenotypes , 2005, Nature Reviews Genetics.

[24]  K. Gärtner,et al.  A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals? , 1990, Laboratory animals.

[25]  T. Hensch.  Critical period plasticity in local cortical circuits , 2005, Nature Reviews Neuroscience.

[26]  Thomas M Jessell,et al.  Development The decade of the developing brain , 2000, Current Opinion in Neurobiology.

[27]  K. Davis,et al.  Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia , 2006, Proceedings of the National Academy of Sciences.

[28]  A. Bergman,et al.  Waddington's canalization revisited: Developmental stability and evolution , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M J Bastiani,et al.  Pathfinding by neuronal growth cones in grasshopper embryos. IV. The effects of ablating the A and P axons upon the behavior of the G growth cone , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[30]  C. Goodman,et al.  Genetic Analysis of the Mechanisms Controlling Target Selection: Complementary and Combinatorial Functions of Netrins, Semaphorins, and IgCAMs , 1998, Cell.

[31]  Troy Shinbrot,et al.  Deterministic and stochastic elements of axonal guidance. , 2005, Annual review of biomedical engineering.

[32]  A. Meyer-Lindenberg,et al.  Intermediate phenotypes and genetic mechanisms of psychiatric disorders , 2006, Nature Reviews Neuroscience.