Immuno(T)herapy for age‐related diseases

During the last decade, the stimulation of T‐cell function by the blockage of immunosuppressive checkpoints has experienced an outstanding impact in the treatment of cancer. Development of the chimeric antigen receptor T‐cell technology has also emerged as a powerful alternative for patients suffering from oncological processes, especially those affected by hematological neoplasms. Recent evidence suggest that the use of immunotherapy could be extended to non‐oncological diseases and could be especially relevant for age‐associated disorders, opening exciting therapeutic options for a wide range of diseases of the elderly. Here we comment on the emergence of T‐cell‐based immunotherapies as feasible approaches that could revolutionize the future of GeroScience.

[1]  J. Bixby,et al.  Reversible CD8 T cell–neuron cross-talk causes aging-dependent neuronal regenerative decline , 2022, Science.

[2]  D. Weissman,et al.  CAR T cells produced in vivo to treat cardiac injury , 2022, Science.

[3]  M. Mittelbrunn,et al.  The role of T cells in age-related diseases , 2021, Nature Reviews Immunology.

[4]  N. LaRusso,et al.  An aged immune system drives senescence and ageing of solid organs , 2021, Nature.

[5]  Maxim N. Artyomov,et al.  Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging. , 2020, Immunity.

[6]  R. Sullivan,et al.  Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque , 2020, Circulation.

[7]  Hannah Stower.  Senolytic CAR T cells , 2020, Nature Network Boston.

[8]  M. Desco,et al.  T cells with dysfunctional mitochondria induce multimorbidity and premature senescence , 2020, Science.

[9]  R. Morishita,et al.  The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice , 2020, Nature Communications.

[10]  Amanda R. Kulick,et al.  Senolytic CAR T cells reverse senescence-associated pathologies , 2020, Nature.

[11]  Mark M. Davis,et al.  Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease , 2020, Nature.

[12]  J. Epstein,et al.  Targeting Cardiac Fibrosis with Engineered T cells , 2019, Nature.

[13]  N. Friedman,et al.  Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes , 2019, Science Advances.

[14]  I. Amit,et al.  PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease , 2016, Nature Medicine.

[15]  C. Akdis,et al.  Role of T cells , 2009 .