Developing a predictive model for vertigo using demographic and laboratory data: An evidence-based medicine approach

Conclusion. The approach described in this paper may be helpful in establishing an early-warning, evidence-based mechanism for diagnosing vertigo, which can be utilized in medical education to reduce medical uncertainty. Objective. To use an evidence-based medicine approach to evaluate the probability of having vertigo using laboratory and demographic data. Material and methods. The study was conducted on 22 working days during July 2002. Targeted cases who visited a general hospital in southern Taiwan for routine physical examinations were asked to participate in the study and agreed to take additional tests during their visits. A total of 200 subjects were systematically and randomly selected from this data pool. We ran binary logistic regression on all these cases. Results. The logistic regression model explained 71.3% of the variance in having vertigo or not. The equation for having vertigo was as follows: −21.855+(1.132×male gender)+(0.071×age)+(−0.023×systolic blood pressure)+(0.057×diastolic blood pressure)+(0.048×fasting glucose)+(0.051×cholesterol)+(−0.005×triglycerides)+(−0.361×presence of cardiovascular diseases).

[1]  A. Horvath,et al.  Systematic reviews in laboratory medicine: principles, processes and practical considerations. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[2]  A. Ishiyama,et al.  Histopathology of Idiopathic Chronic Recurrent Vertigo , 1996, The Laryngoscope.

[3]  C. Rohatgi,et al.  Training surgeons to do evidence-based surgery: a collaborative approach. , 2004, Journal of the American College of Surgeons.

[4]  J. Guilemany,et al.  Clinical and epidemiological study of vertigo at an outpatient clinic , 2004, Acta oto-laryngologica.

[5]  J. T. Spencer Hyperlipoproteinemias in the etiology of inner ear disease , 1973, The Laryngoscope.

[6]  David A. Froehling,et al.  Benign positional vertigo: incidence and prognosis in a population-based study in Olmsted County, Minnesota. , 1991, Mayo Clinic proceedings.

[7]  R. Baloh,et al.  Benign positional vertigo , 1987, Neurology.

[8]  M. Bergsneider,et al.  Vascular Compression Syndrome of the Vestibular Nerve: A Critical Analysis , 1995, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[9]  K. Kroenke,et al.  Common symptoms in ambulatory care: incidence, evaluation, therapy, and outcome. , 1989, The American journal of medicine.

[10]  A. Ghosh,et al.  On the challenges of using evidence-based information: the role of clinical uncertainty. , 2004, The Journal of laboratory and clinical medicine.

[11]  H. Saadah Vestibular vertigo associated with hyperlipidemia: response to antilipidemic therapy. , 1993, Archives of internal medicine.

[12]  T. Sekitani,et al.  Vestibular neuronitis in aged patients: results from an epidemiological survey by questionnaire in Japan. , 1993, Acta oto-laryngologica. Supplementum.

[13]  H. Pillsbury Hypertension, hyperlipoproteinemia, chronic noise exposure: Is there synergism in cochlear pathology? , 1986, The Laryngoscope.

[14]  P. Sloane,et al.  Dizziness: State of the Science , 2001, Annals of Internal Medicine.

[15]  B. Norrving,et al.  Isolated acute vertigo in the elderly; vestibular or vascular disease? , 1995, Acta neurologica Scandinavica.

[16]  R. Helfert,et al.  Balance and Aging , 1999, The Laryngoscope.

[17]  G. Duncan,et al.  Acute cerebellar infarction in the PICA territory. , 1975, Transactions of the American Neurological Association.

[18]  M. González-Gay,et al.  Giant Cell Arteritis: A New Association with Benign Paroxysmal Positional Vertigo , 2004, The Laryngoscope.

[19]  A. Katsarkas,et al.  Paroxysmal positional vertigo--a study of 255 cases. , 1978, The Journal of otolaryngology.