Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

[1]  G. Collingridge,et al.  Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices , 2021, Neuropharmacology.

[2]  I. S. Stein,et al.  Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines , 2020, bioRxiv.

[3]  M. Quirk,et al.  Neuroactive Steroid N-Methyl-D-aspartate Receptor (NMDAR) Positive Allosteric Modulators: Synthesis, SAR and Pharmacological Activity. , 2019, Journal of medicinal chemistry.

[4]  G. Collingridge,et al.  Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid. , 2019, European journal of medicinal chemistry.

[5]  P. Paoletti,et al.  Unmasking GluN1/GluN3A excitatory glycine NMDA receptors , 2018, Nature Communications.

[6]  J. Mellor,et al.  Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus , 2018, The Journal of Neuroscience.

[7]  T. Bliss,et al.  Long-term potentiation in the hippocampus: discovery, mechanisms and function , 2018, Neuroforum.

[8]  G. Collingridge,et al.  Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity , 2018, Neuropharmacology.

[9]  S. Dravid,et al.  Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model , 2018, Neuroscience.

[10]  A. Reiner,et al.  Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert , 2018, Neuron.

[11]  J. Kauer,et al.  Persistent but Labile Synaptic Plasticity at Excitatory Synapses , 2018, The Journal of Neuroscience.

[12]  P. Paoletti,et al.  Triheteromeric NMDA receptors: from structure to synaptic physiology. , 2018, Current opinion in physiology.

[13]  D. Jane,et al.  Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action. , 2018, Journal of medicinal chemistry.

[14]  K. Chergui,et al.  CIQ, a positive allosteric modulator of GluN2C/D‐containing N‐methyl‐d‐aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease , 2018, CNS neuroscience & therapeutics.

[15]  G. Collingridge,et al.  Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives , 2017, Neuropharmacology.

[16]  Eduardo Camina,et al.  The Neuroanatomical, Neurophysiological and Psychological Basis of Memory: Current Models and Their Origins , 2017, Front. Pharmacol..

[17]  G. Collingridge,et al.  Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus , 2017, Neuropharmacology.

[18]  John F. Wesseling,et al.  Emerging roles of GluN3-containing NMDA receptors in the CNS , 2016, Nature Reviews Neuroscience.

[19]  Ying Huang,et al.  Ketamine Protects Gamma Oscillations by Inhibiting Hippocampal LTD , 2016, PloS one.

[20]  R. Malinow,et al.  The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging , 2016, Front. Synaptic Neurosci..

[21]  S. J. Guzman,et al.  P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction , 2016, Neural plasticity.

[22]  Benjamin D. Sellers,et al.  Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. , 2016, Journal of medicinal chemistry.

[23]  Benjamin D. Sellers,et al.  Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function , 2016, Neuron.

[24]  G. Collingridge,et al.  Long-term potentiation and the role of N-methyl-d-aspartate receptors , 2015, Brain Research.

[25]  G. Collingridge,et al.  Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-d-aspartate Receptor Allosteric Modulators , 2015, Synthesis.

[26]  Y. Izumi,et al.  Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function , 2014, Neuropharmacology.

[27]  Sadegh Nabavi,et al.  Engineering a memory with LTD and LTP , 2014, Nature.

[28]  R. Malenka,et al.  Ionotropic NMDA Receptor Signaling Is Required for the Induction of Long-Term Depression in the Mouse Hippocampal CA1 Region , 2014, The Journal of Neuroscience.

[29]  D. Muller,et al.  GluN3A: An NMDA Receptor Subunit with Exquisite Properties and Functions , 2013, Neural plasticity.

[30]  G. Hardingham,et al.  Influence of GluN2 subunit identity on NMDA receptor function , 2013, Neuropharmacology.

[31]  Gabriel M. Belfort,et al.  The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-d-Aspartate Receptors , 2013, The Journal of Neuroscience.

[32]  Qiang Zhou,et al.  NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease , 2013, Nature Reviews Neuroscience.

[33]  R. Malinow,et al.  Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression , 2013, Proceedings of the National Academy of Sciences.

[34]  G. Collingridge,et al.  The roles of STP and LTP in synaptic encoding , 2013, PeerJ.

[35]  G. Collingridge,et al.  Different NMDA receptor subtypes mediate induction of long‐term potentiation and two forms of short‐term potentiation at CA1 synapses in rat hippocampus in vitro , 2013, The Journal of physiology.

[36]  David Lodge,et al.  The NMDA receptor as a target for cognitive enhancement , 2013, Neuropharmacology.

[37]  T. Bliss,et al.  Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide , 2013, Molecular Brain.

[38]  H. Markowitsch,et al.  Amnesic disorders , 2012, The Lancet.

[39]  G. Collingridge,et al.  Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors , 2012, Neurochemistry International.

[40]  D. Jane,et al.  Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators , 2012, Neurochemistry International.

[41]  Graham L. Collingridge,et al.  Automated multi-slice extracellular and patch-clamp experiments using the WinLTP data acquisition system with automated perfusion control , 2012, Journal of Neuroscience Methods.

[42]  Ryan S. Roark,et al.  Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors , 2012, Steroids.

[43]  Y. T. Wang,et al.  Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression , 2011, Molecular Brain.

[44]  W. Lu,et al.  Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons , 2011, Neuropsychopharmacology.

[45]  P. Paoletti Molecular basis of NMDA receptor functional diversity , 2011, The European journal of neuroscience.

[46]  S. Lipton,et al.  NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity , 2011, Nature Neuroscience.

[47]  D. Skifter,et al.  A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors , 2010, Journal of Pharmacology and Experimental Therapeutics.

[48]  D. Liotta,et al.  A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. , 2010, Nature Communications.

[49]  D. Liotta,et al.  Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. , 2010, Journal of medicinal chemistry.

[50]  G. Collingridge,et al.  Long-term depression in the CNS , 2010, Nature Reviews Neuroscience.

[51]  M. Jensen,et al.  Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis , 2010, Neurobiology of Aging.

[52]  M. Moloney Excitatory Amino Acids. , 2010 .

[53]  J. Arrang,et al.  Histamine Potentiates N-Methyl-d-aspartate Receptors by Interacting with an Allosteric Site Distinct from the Polyamine Binding Site , 2010, Journal of Pharmacology and Experimental Therapeutics.

[54]  M. Sokabe,et al.  Modulatory metaplasticity induced by pregnenolone sulfate in the rat hippocampus: A leftward shift in LTP/LTD‐frequency curve , 2009, Hippocampus.

[55]  H. Dringenberg,et al.  Histamine facilitates in vivo thalamocortical long‐term potentiation in the mature visual cortex of anesthetized rats , 2008, The European journal of neuroscience.

[56]  J. Bockaert,et al.  Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors* , 2008, Journal of Biological Chemistry.

[57]  M. Raiteri,et al.  Functional interactions between presynaptic NMDA receptors and metabotropic glutamate receptors co‐expressed on rat and human noradrenergic terminals , 2007, British journal of pharmacology.

[58]  H. Wigström,et al.  Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity , 2007, BMC Neuroscience.

[59]  Graham L. Collingridge,et al.  Capabilities of the WinLTP data acquisition program extending beyond basic LTP experimental functions , 2007, Journal of Neuroscience Methods.

[60]  D. Gruol,et al.  Steroid pregnenolone sulfate enhances NMDA‐receptor‐independent long‐term potentiation at hippocampal CA1 synapses: Role for L‐type calcium channels and sigma‐receptors , 2007, Hippocampus.

[61]  J. Lambert,et al.  Post-tetanic potentiation of GABAergic IPSCs in cultured hippocampal neurons is exclusively time-dependent , 2007, Brain Research.

[62]  Nicola S. Clayton,et al.  Episodic Memory , 2019, Encyclopedia of Animal Cognition and Behavior.

[63]  M. Bear,et al.  Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression , 2007, Neuropharmacology.

[64]  David Lodge,et al.  Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus , 2007, Neuropharmacology.

[65]  L. Vyklický,et al.  Subtype-dependence of N-methyl-d-aspartate receptor modulation by pregnenolone sulfate , 2006, Neuroscience.

[66]  V. Pawlak,et al.  Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation , 2005, The Journal of Neuroscience.

[67]  M. Schumacher,et al.  Pregnenolone sulfate enhances long‐term potentiation in CA1 in rat hippocampus slices through the modulation of N‐methyl‐D‐aspartate receptors , 2004, Journal of neuroscience research.

[68]  G. Collingridge,et al.  Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression , 2004, The Journal of Neuroscience.

[69]  J. Clements,et al.  Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. , 2004, Molecular pharmacology.

[70]  M. Sheng,et al.  Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity , 2004, Science.

[71]  M. Jensen,et al.  Transient and sustained types of long‐term potentiation in the CA1 area of the rat hippocampus , 2003, The Journal of physiology.

[72]  W. Abraham How long will long-term potentiation last? , 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[73]  W. Abraham,et al.  Induction and Experience-Dependent Consolidation of Stable Long-Term Potentiation Lasting Months in the Hippocampus , 2002, The Journal of Neuroscience.

[74]  Y. Kuroda,et al.  Cooperativity between extracellular adenosine 5′-triphosphate and activation of N-methyl-D-aspartate receptors in long-term potentiation induction in hippocampal CA1 neurons , 2002, Neuroscience.

[75]  Hiroto Takahashi,et al.  Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits , 2002, Nature.

[76]  D. Farb,et al.  Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids , 2002, British journal of pharmacology.

[77]  G. Collingridge,et al.  An electrophysiological characterisation of long-term potentiation in cultured dissociated hippocampal neurones , 2001, Neuropharmacology.

[78]  Wei-Yang Lu,et al.  Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons , 2001, Neuron.

[79]  A. El Manira,et al.  Interaction between Metabotropic and Ionotropic Glutamate Receptors Regulates Neuronal Network Activity , 2000, The Journal of Neuroscience.

[80]  S. Hrabetova,et al.  Distinct NMDA Receptor Subpopulations Contribute to Long-Term Potentiation and Long- Term Depression Induction , 2000, The Journal of Neuroscience.

[81]  E. Kandel,et al.  Neural Science: A Century of Progress and the Mysteries that Remain , 2000, Neuron.

[82]  D. Debanne,et al.  Heterogeneity of Synaptic Plasticity at Unitary CA3–CA1 and CA3–CA3 Connections in Rat Hippocampal Slice Cultures , 1999, The Journal of Neuroscience.

[83]  C. Stevens Memory: From Mind to Molecules , 1999, Nature Medicine.

[84]  Y. Kuroda,et al.  Extracellular adenosine 5′-triphosphate plus activation of glutamatergic receptors induces long-term potentiation in CA1 neurons of guinea pig hippocampal slices , 1999, Neuroscience Letters.

[85]  M. Bear Homosynaptic long-term depression: a mechanism for memory? , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[86]  J. Lisman,et al.  Requirements for LTP induction by pairing in hippocampal CA1 pyramidal cells. , 1999, Journal of neurophysiology.

[87]  D. Goebel,et al.  NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A. , 1999, Brain research. Molecular brain research.

[88]  Z. Bortolotto,et al.  The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity , 1998, Neuropharmacology.

[89]  Mark F Bear,et al.  NMDA Induces Long-Term Synaptic Depression and Dephosphorylation of the GluR1 Subunit of AMPA Receptors in Hippocampus , 1998, Neuron.

[90]  S. Vicini,et al.  Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. , 1998, Journal of neurophysiology.

[91]  R. Purdy,et al.  Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids. , 1997, Molecular pharmacology.

[92]  G. R. Seabrook,et al.  The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus , 1997, Neuropharmacology.

[93]  G Tocco,et al.  Glycine-induced long-term potentiation is associated with structural and functional modifications of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid receptors. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[94]  P. Schulz,et al.  Differing mechanisms of expression for short- and long-term potentiation. , 1997, Journal of neurophysiology.

[95]  Sabina Hrabetova,et al.  Long-term potentiation and long-term depression are induced through pharmacologically distinct NMDA receptors 1 Portions of this work were previously published in abstract form [11]. 1 , 1997, Neuroscience Letters.

[96]  G. Collingridge,et al.  Activation of group I mG1uRs potentiates NMDA responses in rat hippocampal slices , 1996, Neuroscience Letters.

[97]  R. E. Brown,et al.  Histaminergic modulation of synaptic plasticity in area CA1 of rat hippocampal slices , 1995, Neuropharmacology.

[98]  K. Williams Subunit-specific potentiation of recombinant N-methyl-D-aspartate receptors by histamine. , 1994, Molecular pharmacology.

[99]  Susumu Tonegawa,et al.  The role of calcium–calmodulin kinase II in three forms of synaptic plasticity , 1994, Current Biology.

[100]  K. Williams Mechanisms influencing stimulatory effects of spermine at recombinant N-methyl-D-aspartate receptors. , 1994, Molecular pharmacology.

[101]  B. Sakmann,et al.  Developmental and regional expression in the rat brain and functional properties of four NMDA receptors , 1994, Neuron.

[102]  Masahiko Watanabe,et al.  Distinct distributions of five N‐methyl‐D‐aspartate receptor channel subunit mRNAs in the forebrain , 1993, The Journal of comparative neurology.

[103]  Masahiko Watanabe,et al.  Distinct Spatio‐temporal Distributions of the NMDA Receptor Channel Subunit mRNAs in the Brain , 1993, Annals of the New York Academy of Sciences.

[104]  M. Baudry,et al.  Glycine-induced changes in synaptic efficacy in hippocampal slices involve changes in AMPA receptors , 1993, Brain Research.

[105]  M. Baudry,et al.  High concentrations of glycine induce long-lasting changes in synaptic efficacy in rat hippocampal slices , 1993, Neuroscience Letters.

[106]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[107]  P. Stern,et al.  Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors , 1992, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[108]  K. Sakimura,et al.  Developmental changes in distribution of NMDA receptor channel subunit mRNAs. , 1992, Neuroreport.

[109]  Dimitri M. Kullmann,et al.  Ca2+ Entry via postsynaptic voltage-sensitive Ca2+ channels can transiently potentiate excitatory synaptic transmission in the hippocampus , 1992, Neuron.

[110]  H. Saito,et al.  Effects of glycine and structurally related amino acids on generation of long-term potentiation in rat hippocampal slices. , 1992, European journal of pharmacology.

[111]  K. Abe,et al.  Spermine facilitates the generation of long-term potentiation of evoked potential in the dentate gyrus of anesthetized rats , 1992, Brain Research.

[112]  Bert Sakmann,et al.  Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes , 1992, Science.

[113]  M. Bear,et al.  Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[114]  R. Anwyl,et al.  Inhibition of an N-methyl-d-aspartate induced short-term potentiation in the rat hippocampal slice , 1991, Brain Research.

[115]  R. Anwyl,et al.  The effects of external calcium on the N-methyl-d-aspartate induced short-term potentiation in the rat hippocampal slice , 1991, Neuroscience Letters.

[116]  H. Wigström,et al.  Synaptic potentiation in the hippocampal CA1 region induced by application ofN-methyl-d-aspartate , 1991, Brain Research.

[117]  Robert C. Malenka,et al.  Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus , 1991, Neuron.

[118]  R. Tsien,et al.  Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices , 1990, Nature.

[119]  G. Collingridge,et al.  Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP , 1990, Neuroscience Letters.

[120]  T. Seyfried,et al.  ATP-induced synaptic potentiation in hippocampal slices , 1989, Brain Research.

[121]  G. Lynch,et al.  Long-lasting physiological effects of bath applied N-methyl-d-aspartate , 1989, Brain Research.

[122]  R. Dingledine,et al.  Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. , 1988, Science.

[123]  R. Nicoll,et al.  NMDA application potentiates synaptic transmission in the hippocampus , 1988, Nature.

[124]  G. Collingridge,et al.  MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices , 1987, Neuroscience Letters.

[125]  P. Ascher,et al.  Glycine potentiates the NMDA response in cultured mouse brain neurons , 1987, Nature.

[126]  G. Lynch,et al.  Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation , 1986, Brain Research.

[127]  M. Mayer,et al.  Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones , 1984, Nature.

[128]  L. Nowak,et al.  Magnesium gates glutamate-activated channels in mouse central neurones , 1984, Nature.

[129]  J. L. Stringer,et al.  Blockade of long-term potentiation by phencyclidine and σ opiates in the hippocampus in vivo and in vitro , 1983, Brain Research.

[130]  R. Racine,et al.  Long-term potentiation phenomena in the rat limbic forebrain , 1983, Brain Research.

[131]  R. Racine,et al.  Short-term potentiation phenomena in the rat limbic forebrain , 1983, Brain Research.

[132]  J. L. Stringer,et al.  Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine , 1983, Brain Research.

[133]  B L McNaughton,et al.  Long‐term synaptic enhancement and short‐term potentiation in rat fascia dentata act through different mechanisms , 1982, The Journal of physiology.

[134]  G. Lynch,et al.  Long‐term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency. , 1978, The Journal of physiology.

[135]  G. Lynch,et al.  Heterosynaptic depression: a postsynaptic correlate of long-term potentiation , 1977, Nature.

[136]  P. Andersen,et al.  Specific long-lasting potentiation of synaptic transmission in hippocampal slices , 1977, Nature.

[137]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.

[138]  K. Skrede,et al.  The transverse hippocampal slice: a well-defined cortical structure maintained in vitro. , 1971, Brain research.

[139]  D. Hackos,et al.  Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences , 2017, Neuropharmacology.

[140]  L. Nadel,et al.  Update on Memory Systems and Processes , 2011, Neuropsychopharmacology.

[141]  T. Bliss Long-lasting potentiation of synaptic transmission , 2005 .

[142]  G. Collingridge,et al.  Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis , 2004, Experimental Brain Research.

[143]  W. Regehr,et al.  Short-term synaptic plasticity. , 2002, Annual review of physiology.

[144]  Michael D. Kopelman,et al.  Handbook of memory disorders , 1995 .

[145]  Y. Prigent [Long term depression]. , 1989, Annales medico-psychologiques.

[146]  G. Lynch,et al.  Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5 , 1986, Nature.

[147]  G. Collingridge,et al.  Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus. , 1983, The Journal of physiology.

[148]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.